======= MRPL42 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL42
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L42
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28977|28977]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6G3|Q9Y6G3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL42&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL42|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611847|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRP-S32|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial small ribosomal subunit|
|mitochondrial large ribosomal subunit|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.8|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.85|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.92|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.95|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dap3|DAP3]]|0.595|
|[[:human genes:m:mrp63|MRP63]]|0.587|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.584|
|[[:human genes:m:mrps21|MRPS21]]|0.583|
|[[:human genes:m:mrpl21|MRPL21]]|0.582|
|[[:human genes:m:mrps6|MRPS6]]|0.578|
|[[:human genes:n:nars2|NARS2]]|0.576|
|[[:human genes:m:mrps34|MRPS34]]|0.571|
|[[:human genes:q:qrsl1|QRSL1]]|0.554|
|[[:human genes:m:mrps5|MRPS5]]|0.553|
|[[:human genes:m:mrps14|MRPS14]]|0.552|
|[[:human genes:y:yars2|YARS2]]|0.549|
|[[:human genes:m:mrpl47|MRPL47]]|0.546|
|[[:human genes:e:ears2|EARS2]]|0.541|
|[[:human genes:p:pars2|PARS2]]|0.538|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.537|
|[[:human genes:d:dars2|DARS2]]|0.534|
|[[:human genes:m:mrps26|MRPS26]]|0.519|
|[[:human genes:l:lars2|LARS2]]|0.516|
|[[:human genes:g:gfm1|GFM1]]|0.515|
|[[:human genes:r:rars2|RARS2]]|0.515|
|[[:human genes:w:wbscr16|WBSCR16]]|0.514|
|[[:human genes:m:mrpl45|MRPL45]]|0.514|
|[[:human genes:m:mrpl23|MRPL23]]|0.514|
|[[:human genes:h:hars2|HARS2]]|0.513|
|[[:human genes:s:selrc1|SELRC1]]|0.513|
|[[:human genes:m:mrps10|MRPS10]]|0.511|
|[[:human genes:c:cox16|COX16]]|0.51|
|[[:human genes:g:gfm2|GFM2]]|0.509|
|[[:human genes:t:tars2|TARS2]]|0.501|
|[[:human genes:m:mrpl3|MRPL3]]|0.5|
|[[:human genes:m:mrps9|MRPS9]]|0.495|
|[[:human genes:m:mrps35|MRPS35]]|0.493|
|[[:human genes:s:sco2|SCO2]]|0.493|
|[[:human genes:m:mrpl53|MRPL53]]|0.493|
|[[:human genes:m:mrps16|MRPS16]]|0.491|
|[[:human genes:v:vars2|VARS2]]|0.49|
|[[:human genes:m:mrps18a|MRPS18A]]|0.489|
|[[:human genes:m:mettl17|METTL17]]|0.489|
|[[:human genes:t:trub2|TRUB2]]|0.489|
|[[:human genes:d:ddx28|DDX28]]|0.486|
|[[:human genes:p:polrmt|POLRMT]]|0.485|
|[[:human genes:m:mars2|MARS2]]|0.484|
|[[:human genes:m:mrps23|MRPS23]]|0.483|
|[[:human genes:m:mrpl12|MRPL12]]|0.483|
|[[:human genes:f:ftsj2|FTSJ2]]|0.482|
|[[:human genes:p:pet112|PET112]]|0.477|
|[[:human genes:a:aifm1|AIFM1]]|0.476|
|[[:human genes:p:pnpt1|PNPT1]]|0.476|
|[[:human genes:n:ndufb11|NDUFB11]]|0.476|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.474|
|[[:human genes:r:rbfa|RBFA]]|0.473|
|[[:human genes:t:tufm|TUFM]]|0.472|
|[[:human genes:m:mrpl17|MRPL17]]|0.468|
|[[:human genes:m:mrpl15|MRPL15]]|0.467|
|[[:human genes:p:ptcd3|PTCD3]]|0.462|
|[[:human genes:n:ndufa3|NDUFA3]]|0.462|
|[[:human genes:m:mrps12|MRPS12]]|0.46|
|[[:human genes:s:sars2|SARS2]]|0.459|
|[[:human genes:m:mrps25|MRPS25]]|0.457|
|[[:human genes:t:tfam|TFAM]]|0.457|
|[[:human genes:m:mtpap|MTPAP]]|0.456|
|[[:human genes:p:polg2|POLG2]]|0.453|
|[[:human genes:f:fastkd5|FASTKD5]]|0.451|
|[[:human genes:m:mrpl33|MRPL33]]|0.448|
|[[:human genes:m:mrps33|MRPS33]]|0.446|
|[[:human genes:c:coa3|COA3]]|0.445|
|[[:human genes:m:mrps2|MRPS2]]|0.442|
|[[:human genes:m:mrpl13|MRPL13]]|0.441|
|[[:human genes:n:ndufc2|NDUFC2]]|0.441|
|[[:human genes:m:mrpl39|MRPL39]]|0.44|
|[[:human genes:a:atp5sl|ATP5SL]]|0.44|
|[[:human genes:s:slc25a26|SLC25A26]]|0.44|
|[[:human genes:m:mrps22|MRPS22]]|0.439|
|[[:human genes:f:fars2|FARS2]]|0.439|
|[[:human genes:b:bcs1l|BCS1L]]|0.436|
|[[:human genes:t:tefm|TEFM]]|0.434|
|[[:human genes:m:mrps11|MRPS11]]|0.434|
|[[:human genes:m:mrpl44|MRPL44]]|0.434|
|[[:human genes:m:mrpl11|MRPL11]]|0.434|
|[[:human genes:c:cox19|COX19]]|0.432|
|[[:human genes:m:mrpl46|MRPL46]]|0.431|
|[[:human genes:a:aars2|AARS2]]|0.431|
|[[:human genes:c:cox17|COX17]]|0.431|
|[[:human genes:g:gatc|GATC]]|0.43|
|[[:human genes:n:ndufa1|NDUFA1]]|0.43|
|[[:human genes:r:rpusd4|RPUSD4]]|0.428|
|[[:human genes:u:uqcr10|UQCR10]]|0.426|
|[[:human genes:c:chchd1|CHCHD1]]|0.426|
|[[:human genes:m:mrps7|MRPS7]]|0.425|
|[[:human genes:m:mterfd1|MTERFD1]]|0.423|
|[[:human genes:m:mrpl4|MRPL4]]|0.422|
|[[:human genes:m:mrpl51|MRPL51]]|0.421|
|[[:human genes:m:mrpl43|MRPL43]]|0.421|
|[[:human genes:m:mrpl52|MRPL52]]|0.421|
|[[:human genes:m:mrpl55|MRPL55]]|0.42|
|[[:human genes:n:ndufb9|NDUFB9]]|0.419|
|[[:human genes:m:mrpl18|MRPL18]]|0.419|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.416|
|[[:human genes:m:mrps24|MRPS24]]|0.414|
|[[:human genes:m:mtg1|MTG1]]|0.413|
|[[:human genes:c:c10orf2|C10orf2]]|0.412|
|[[:human genes:c:cox11|COX11]]|0.412|
|[[:human genes:c:c12orf65|C12orf65]]|0.412|
|[[:human genes:m:mtg2|MTG2]]|0.412|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.412|
|[[:human genes:m:mrps27|MRPS27]]|0.41|
|[[:human genes:c:cars2|CARS2]]|0.408|
|[[:human genes:m:mrpl36|MRPL36]]|0.408|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.407|
|[[:human genes:c:cox7b|COX7B]]|0.404|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.404|
|[[:human genes:p:pgm3|PGM3]]|0.404|
|[[:human genes:m:mtif2|MTIF2]]|0.404|
|[[:human genes:p:pet117|PET117]]|0.402|
|[[:human genes:c:coa6|COA6]]|0.401|
|[[:human genes:m:mrpl34|MRPL34]]|0.4|
|[[:human genes:w:wars2|WARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1924
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL42 Expression in NALM6 Cells: 6.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>