======= MRPL46 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL46
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L46
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26589|26589]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2W6|Q9H2W6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL46&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL46|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611851|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRP-L46|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit|
|hydrolase activity|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cell junction|
|molecular function|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.7|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.81|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.82|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.83|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.86|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.95|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.97|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.02|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps21|MRPS21]]|0.522|
|[[:human genes:m:mrpl21|MRPL21]]|0.513|
|[[:human genes:m:mrps34|MRPS34]]|0.497|
|[[:human genes:m:mrpl23|MRPL23]]|0.493|
|[[:human genes:m:mrps25|MRPS25]]|0.486|
|[[:human genes:r:rpusd4|RPUSD4]]|0.48|
|[[:human genes:m:mrps5|MRPS5]]|0.471|
|[[:human genes:m:mrp63|MRP63]]|0.466|
|[[:human genes:m:mrps6|MRPS6]]|0.461|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.456|
|[[:human genes:m:mrps24|MRPS24]]|0.455|
|[[:human genes:v:vars2|VARS2]]|0.455|
|[[:human genes:y:yars2|YARS2]]|0.454|
|[[:human genes:d:dap3|DAP3]]|0.452|
|[[:human genes:f:fars2|FARS2]]|0.449|
|[[:human genes:t:trub2|TRUB2]]|0.449|
|[[:human genes:n:ndufa3|NDUFA3]]|0.448|
|[[:human genes:t:tars2|TARS2]]|0.445|
|[[:human genes:n:ndufb11|NDUFB11]]|0.445|
|[[:human genes:m:mrpl55|MRPL55]]|0.443|
|[[:human genes:q:qrsl1|QRSL1]]|0.443|
|[[:human genes:l:lars2|LARS2]]|0.442|
|[[:human genes:n:nars2|NARS2]]|0.44|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.438|
|[[:human genes:m:mrpl12|MRPL12]]|0.438|
|[[:human genes:f:fastkd5|FASTKD5]]|0.435|
|[[:human genes:g:gfm1|GFM1]]|0.435|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.433|
|[[:human genes:p:pars2|PARS2]]|0.431|
|[[:human genes:m:mrpl42|MRPL42]]|0.431|
|[[:human genes:m:mrpl53|MRPL53]]|0.43|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.421|
|[[:human genes:c:c17orf89|C17orf89]]|0.42|
|[[:human genes:c:c12orf65|C12orf65]]|0.419|
|[[:human genes:m:mrps7|MRPS7]]|0.417|
|[[:human genes:n:ndufb6|NDUFB6]]|0.417|
|[[:human genes:n:ndufc2|NDUFC2]]|0.416|
|[[:human genes:s:selrc1|SELRC1]]|0.415|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.415|
|[[:human genes:r:rbfa|RBFA]]|0.413|
|[[:human genes:t:tufm|TUFM]]|0.413|
|[[:human genes:m:mrpl47|MRPL47]]|0.412|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.412|
|[[:human genes:m:mrps35|MRPS35]]|0.408|
|[[:human genes:c:chchd1|CHCHD1]]|0.405|
|[[:human genes:m:mrpl45|MRPL45]]|0.402|
|[[:human genes:w:wbscr16|WBSCR16]]|0.401|
|[[:human genes:m:mrps18a|MRPS18A]]|0.401|
|[[:human genes:m:mrps10|MRPS10]]|0.4|
|[[:human genes:m:mrps26|MRPS26]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1102
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL46 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>