======= MRPS16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS16
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51021|51021]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3D3|Q9Y3D3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609204|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S16|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial small ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-2|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.8|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.73|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.77|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.78|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.82|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.86|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.88|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.89|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.91|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.01|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.03|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.03|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.17|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.741|
|[[:human genes:t:tars2|TARS2]]|0.707|
|[[:human genes:y:yars2|YARS2]]|0.707|
|[[:human genes:m:mrps6|MRPS6]]|0.705|
|[[:human genes:d:dap3|DAP3]]|0.704|
|[[:human genes:m:mrps21|MRPS21]]|0.693|
|[[:human genes:c:cox16|COX16]]|0.69|
|[[:human genes:m:mrps34|MRPS34]]|0.689|
|[[:human genes:g:gfm1|GFM1]]|0.687|
|[[:human genes:m:mrps14|MRPS14]]|0.686|
|[[:human genes:n:nars2|NARS2]]|0.685|
|[[:human genes:d:dars2|DARS2]]|0.682|
|[[:human genes:s:selrc1|SELRC1]]|0.682|
|[[:human genes:r:rpusd4|RPUSD4]]|0.681|
|[[:human genes:m:mrpl21|MRPL21]]|0.676|
|[[:human genes:s:sco2|SCO2]]|0.676|
|[[:human genes:v:vars2|VARS2]]|0.672|
|[[:human genes:m:mars2|MARS2]]|0.663|
|[[:human genes:l:lars2|LARS2]]|0.663|
|[[:human genes:m:mrpl53|MRPL53]]|0.663|
|[[:human genes:r:rbfa|RBFA]]|0.66|
|[[:human genes:p:pars2|PARS2]]|0.657|
|[[:human genes:m:mrps18a|MRPS18A]]|0.649|
|[[:human genes:r:rars2|RARS2]]|0.648|
|[[:human genes:f:fastkd5|FASTKD5]]|0.643|
|[[:human genes:c:coa3|COA3]]|0.643|
|[[:human genes:e:ears2|EARS2]]|0.643|
|[[:human genes:q:qrsl1|QRSL1]]|0.636|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.635|
|[[:human genes:m:mrpl23|MRPL23]]|0.634|
|[[:human genes:n:ndufa3|NDUFA3]]|0.634|
|[[:human genes:m:mrp63|MRP63]]|0.63|
|[[:human genes:c:c12orf65|C12orf65]]|0.625|
|[[:human genes:g:gfm2|GFM2]]|0.621|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.621|
|[[:human genes:h:hars2|HARS2]]|0.621|
|[[:human genes:m:mrps25|MRPS25]]|0.621|
|[[:human genes:p:pet112|PET112]]|0.619|
|[[:human genes:w:wbscr16|WBSCR16]]|0.615|
|[[:human genes:m:mrps5|MRPS5]]|0.615|
|[[:human genes:m:mrpl47|MRPL47]]|0.615|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.614|
|[[:human genes:g:gatc|GATC]]|0.613|
|[[:human genes:m:mrpl45|MRPL45]]|0.613|
|[[:human genes:m:mrps26|MRPS26]]|0.608|
|[[:human genes:m:mtg2|MTG2]]|0.607|
|[[:human genes:m:mrps2|MRPS2]]|0.606|
|[[:human genes:s:sars2|SARS2]]|0.6|
|[[:human genes:f:ftsj2|FTSJ2]]|0.597|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.597|
|[[:human genes:b:bcs1l|BCS1L]]|0.595|
|[[:human genes:c:c10orf2|C10orf2]]|0.595|
|[[:human genes:t:tefm|TEFM]]|0.592|
|[[:human genes:t:trub2|TRUB2]]|0.59|
|[[:human genes:t:tomm20|TOMM20]]|0.588|
|[[:human genes:m:mrps12|MRPS12]]|0.586|
|[[:human genes:t:tufm|TUFM]]|0.585|
|[[:human genes:m:mrps24|MRPS24]]|0.584|
|[[:human genes:m:mrps10|MRPS10]]|0.584|
|[[:human genes:m:mrps9|MRPS9]]|0.583|
|[[:human genes:c:cox17|COX17]]|0.58|
|[[:human genes:n:ndufb11|NDUFB11]]|0.574|
|[[:human genes:m:mrpl20|MRPL20]]|0.569|
|[[:human genes:s:slc25a26|SLC25A26]]|0.568|
|[[:human genes:c:coa6|COA6]]|0.567|
|[[:human genes:a:aars2|AARS2]]|0.566|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.566|
|[[:human genes:p:pdss1|PDSS1]]|0.564|
|[[:human genes:m:mrpl15|MRPL15]]|0.561|
|[[:human genes:f:fars2|FARS2]]|0.561|
|[[:human genes:a:aifm1|AIFM1]]|0.56|
|[[:human genes:m:mrps22|MRPS22]]|0.56|
|[[:human genes:c:cox11|COX11]]|0.56|
|[[:human genes:m:mrps33|MRPS33]]|0.559|
|[[:human genes:p:pnpt1|PNPT1]]|0.557|
|[[:human genes:p:pet117|PET117]]|0.553|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.552|
|[[:human genes:m:mrpl12|MRPL12]]|0.549|
|[[:human genes:m:mtpap|MTPAP]]|0.548|
|[[:human genes:c:cars2|CARS2]]|0.545|
|[[:human genes:c:cox7b|COX7B]]|0.543|
|[[:human genes:e:elac2|ELAC2]]|0.541|
|[[:human genes:m:malsu1|MALSU1]]|0.54|
|[[:human genes:r:rpusd3|RPUSD3]]|0.539|
|[[:human genes:p:pgm3|PGM3]]|0.539|
|[[:human genes:t:triap1|TRIAP1]]|0.538|
|[[:human genes:t:tomm22|TOMM22]]|0.534|
|[[:human genes:m:mrpl3|MRPL3]]|0.53|
|[[:human genes:m:mrpl43|MRPL43]]|0.529|
|[[:human genes:m:mtg1|MTG1]]|0.528|
|[[:human genes:m:mrpl39|MRPL39]]|0.527|
|[[:human genes:m:mrpl22|MRPL22]]|0.525|
|[[:human genes:t:tfb1m|TFB1M]]|0.524|
|[[:human genes:m:mrps11|MRPS11]]|0.524|
|[[:human genes:c:cox15|COX15]]|0.524|
|[[:human genes:n:ndufb6|NDUFB6]]|0.523|
|[[:human genes:m:mrpl33|MRPL33]]|0.523|
|[[:human genes:p:polg|POLG]]|0.523|
|[[:human genes:n:ndufc2|NDUFC2]]|0.522|
|[[:human genes:n:ndufb5|NDUFB5]]|0.522|
|[[:human genes:m:mrps23|MRPS23]]|0.522|
|[[:human genes:e:ecsit|ECSIT]]|0.521|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.519|
|[[:human genes:m:mrpl18|MRPL18]]|0.518|
|[[:human genes:n:ndufa1|NDUFA1]]|0.516|
|[[:human genes:c:cox6c|COX6C]]|0.514|
|[[:human genes:m:mrpl4|MRPL4]]|0.512|
|[[:human genes:p:polg2|POLG2]]|0.511|
|[[:human genes:p:ptcd3|PTCD3]]|0.511|
|[[:human genes:n:ndufa2|NDUFA2]]|0.51|
|[[:human genes:c:c17orf89|C17orf89]]|0.508|
|[[:human genes:m:mrpl44|MRPL44]]|0.507|
|[[:human genes:w:wars2|WARS2]]|0.506|
|[[:human genes:t:tomm40|TOMM40]]|0.506|
|[[:human genes:m:mrps35|MRPS35]]|0.503|
|[[:human genes:t:timm8b|TIMM8B]]|0.502|
|[[:human genes:m:mrps7|MRPS7]]|0.501|
|[[:human genes:m:mrpl11|MRPL11]]|0.5|
|[[:human genes:a:atp5a1|ATP5A1]]|0.497|
|[[:human genes:n:ndufv1|NDUFV1]]|0.496|
|[[:human genes:h:hccs|HCCS]]|0.496|
|[[:human genes:m:mrpl27|MRPL27]]|0.495|
|[[:human genes:a:atp5sl|ATP5SL]]|0.495|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.495|
|[[:human genes:m:mipep|MIPEP]]|0.495|
|[[:human genes:l:lsm10|LSM10]]|0.494|
|[[:human genes:m:mettl17|METTL17]]|0.494|
|[[:human genes:m:mrpl55|MRPL55]]|0.493|
|[[:human genes:t:tmem242|TMEM242]]|0.493|
|[[:human genes:p:pet100|PET100]]|0.492|
|[[:human genes:a:atp5b|ATP5B]]|0.492|
|[[:human genes:d:ddx28|DDX28]]|0.492|
|[[:human genes:m:mrpl42|MRPL42]]|0.491|
|[[:human genes:f:fh|FH]]|0.49|
|[[:human genes:h:higd2a|HIGD2A]]|0.49|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.489|
|[[:human genes:m:mrpl34|MRPL34]]|0.488|
|[[:human genes:c:coq2|COQ2]]|0.487|
|[[:human genes:e:eral1|ERAL1]]|0.487|
|[[:human genes:t:tfam|TFAM]]|0.486|
|[[:human genes:m:mrpl13|MRPL13]]|0.485|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.481|
|[[:human genes:m:mrpl36|MRPL36]]|0.48|
|[[:human genes:a:atxn10|ATXN10]]|0.475|
|[[:human genes:c:chchd4|CHCHD4]]|0.475|
|[[:human genes:m:mrpl17|MRPL17]]|0.474|
|[[:human genes:m:mcat|MCAT]]|0.474|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.472|
|[[:human genes:m:mrps17|MRPS17]]|0.471|
|[[:human genes:a:atp5d|ATP5D]]|0.471|
|[[:human genes:i:iba57|IBA57]]|0.47|
|[[:human genes:c:chchd1|CHCHD1]]|0.469|
|[[:human genes:a:atp5h|ATP5H]]|0.468|
|[[:human genes:u:uqcr10|UQCR10]]|0.467|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.467|
|[[:human genes:m:mterfd2|MTERFD2]]|0.466|
|[[:human genes:p:ppa2|PPA2]]|0.465|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.464|
|[[:human genes:d:dnlz|DNLZ]]|0.464|
|[[:human genes:n:ndufs2|NDUFS2]]|0.462|
|[[:human genes:r:rpia|RPIA]]|0.462|
|[[:human genes:d:dhrsx|DHRSX]]|0.462|
|[[:human genes:o:opa1|OPA1]]|0.461|
|[[:human genes:c:cox20|COX20]]|0.461|
|[[:human genes:c:cycs|CYCS]]|0.461|
|[[:human genes:c:crls1|CRLS1]]|0.459|
|[[:human genes:t:tmem261|TMEM261]]|0.458|
|[[:human genes:a:atp5c1|ATP5C1]]|0.457|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.456|
|[[:human genes:c:coa5|COA5]]|0.453|
|[[:human genes:m:mrpl35|MRPL35]]|0.452|
|[[:human genes:m:mtif3|MTIF3]]|0.451|
|[[:human genes:m:mrpl41|MRPL41]]|0.451|
|[[:human genes:t:trmt61a|TRMT61A]]|0.449|
|[[:human genes:n:nfu1|NFU1]]|0.448|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.447|
|[[:human genes:t:tpk1|TPK1]]|0.446|
|[[:human genes:m:mrps27|MRPS27]]|0.446|
|[[:human genes:a:atp5j|ATP5J]]|0.445|
|[[:human genes:s:slc25a19|SLC25A19]]|0.444|
|[[:human genes:s:ssbp1|SSBP1]]|0.443|
|[[:human genes:a:atic|ATIC]]|0.443|
|[[:human genes:a:acad9|ACAD9]]|0.443|
|[[:human genes:l:lrpprc|LRPPRC]]|0.44|
|[[:human genes:m:mrpl1|MRPL1]]|0.439|
|[[:human genes:c:cox5a|COX5A]]|0.439|
|[[:human genes:a:alg6|ALG6]]|0.438|
|[[:human genes:m:mrpl51|MRPL51]]|0.437|
|[[:human genes:s:ssb|SSB]]|0.437|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.437|
|[[:human genes:p:polrmt|POLRMT]]|0.436|
|[[:human genes:t:tomm6|TOMM6]]|0.436|
|[[:human genes:d:dhx30|DHX30]]|0.434|
|[[:human genes:c:coq3|COQ3]]|0.433|
|[[:human genes:g:grsf1|GRSF1]]|0.432|
|[[:human genes:m:mrpl32|MRPL32]]|0.431|
|[[:human genes:n:ndufb3|NDUFB3]]|0.429|
|[[:human genes:c:cox6b1|COX6B1]]|0.428|
|[[:human genes:s:sco1|SCO1]]|0.427|
|[[:human genes:n:ndufb9|NDUFB9]]|0.427|
|[[:human genes:m:mterfd1|MTERFD1]]|0.426|
|[[:human genes:c:coq5|COQ5]]|0.426|
|[[:human genes:u:uqcc2|UQCC2]]|0.426|
|[[:human genes:t:tmem126b|TMEM126B]]|0.425|
|[[:human genes:n:ndufa11|NDUFA11]]|0.425|
|[[:human genes:d:dpagt1|DPAGT1]]|0.425|
|[[:human genes:c:cox19|COX19]]|0.425|
|[[:human genes:m:mtif2|MTIF2]]|0.424|
|[[:human genes:m:mrpl49|MRPL49]]|0.423|
|[[:human genes:p:pmm2|PMM2]]|0.423|
|[[:human genes:a:atp5o|ATP5O]]|0.423|
|[[:human genes:v:vezt|VEZT]]|0.423|
|[[:human genes:n:ndufa10|NDUFA10]]|0.422|
|[[:human genes:g:glrx5|GLRX5]]|0.422|
|[[:human genes:z:zrsr2|ZRSR2]]|0.421|
|[[:human genes:m:mrpl28|MRPL28]]|0.42|
|[[:human genes:p:pitrm1|PITRM1]]|0.42|
|[[:human genes:m:mrpl52|MRPL52]]|0.418|
|[[:human genes:t:trmt10c|TRMT10C]]|0.418|
|[[:human genes:p:ppcs|PPCS]]|0.418|
|[[:human genes:t:thg1l|THG1L]]|0.417|
|[[:human genes:r:romo1|ROMO1]]|0.415|
|[[:human genes:n:ndufs5|NDUFS5]]|0.414|
|[[:human genes:f:fastkd2|FASTKD2]]|0.414|
|[[:human genes:c:cep57|CEP57]]|0.412|
|[[:human genes:u:uqcrq|UQCRQ]]|0.412|
|[[:human genes:t:tamm41|TAMM41]]|0.412|
|[[:human genes:g:gars|GARS]]|0.412|
|[[:human genes:n:nubpl|NUBPL]]|0.411|
|[[:human genes:s:srd5a3|SRD5A3]]|0.411|
|[[:human genes:n:ndufb4|NDUFB4]]|0.41|
|[[:human genes:c:coq4|COQ4]]|0.408|
|[[:human genes:m:mrpl37|MRPL37]]|0.408|
|[[:human genes:p:ptcd1|PTCD1]]|0.407|
|[[:human genes:t:trmt10a|TRMT10A]]|0.407|
|[[:human genes:n:ndufs7|NDUFS7]]|0.405|
|[[:human genes:t:tfb2m|TFB2M]]|0.402|
|[[:human genes:a:alas1|ALAS1]]|0.401|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 122/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|4/28|
|bone|3/26|
|breast|6/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|5/20|
|lung|20/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1118
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS16 Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>