======= MRPS17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS17
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51373|51373]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2R5|Q9Y2R5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial small ribosomal subunit|
|rRNA binding|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.71|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.7|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.7|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.75|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.75|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.76|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.82|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.83|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.88|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.9|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.95|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.97|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gatc|GATC]]|0.561|
|[[:human genes:m:mrpl21|MRPL21]]|0.523|
|[[:human genes:v:vars2|VARS2]]|0.505|
|[[:human genes:m:mrps21|MRPS21]]|0.504|
|[[:human genes:y:yars2|YARS2]]|0.501|
|[[:human genes:m:mrpl53|MRPL53]]|0.499|
|[[:human genes:n:ndufb11|NDUFB11]]|0.494|
|[[:human genes:t:tufm|TUFM]]|0.489|
|[[:human genes:g:gfm1|GFM1]]|0.487|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.487|
|[[:human genes:m:mrps5|MRPS5]]|0.486|
|[[:human genes:t:tefm|TEFM]]|0.48|
|[[:human genes:p:polg|POLG]]|0.478|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.478|
|[[:human genes:f:ftsj2|FTSJ2]]|0.473|
|[[:human genes:m:mrps24|MRPS24]]|0.473|
|[[:human genes:m:mrps16|MRPS16]]|0.471|
|[[:human genes:n:nars2|NARS2]]|0.469|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.469|
|[[:human genes:r:rbfa|RBFA]]|0.468|
|[[:human genes:l:lars2|LARS2]]|0.467|
|[[:human genes:m:mrps34|MRPS34]]|0.464|
|[[:human genes:n:ndufa3|NDUFA3]]|0.464|
|[[:human genes:c:c12orf65|C12orf65]]|0.458|
|[[:human genes:d:dap3|DAP3]]|0.458|
|[[:human genes:m:mrpl47|MRPL47]]|0.457|
|[[:human genes:m:mrps14|MRPS14]]|0.452|
|[[:human genes:m:mrps10|MRPS10]]|0.45|
|[[:human genes:m:mrps18a|MRPS18A]]|0.447|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.445|
|[[:human genes:m:mrps33|MRPS33]]|0.445|
|[[:human genes:n:ndufb3|NDUFB3]]|0.442|
|[[:human genes:u:uqcr10|UQCR10]]|0.44|
|[[:human genes:q:qrsl1|QRSL1]]|0.438|
|[[:human genes:p:pnpt1|PNPT1]]|0.437|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.437|
|[[:human genes:d:dhrsx|DHRSX]]|0.435|
|[[:human genes:m:mipep|MIPEP]]|0.434|
|[[:human genes:m:mrps11|MRPS11]]|0.434|
|[[:human genes:d:dars2|DARS2]]|0.434|
|[[:human genes:n:ndufb6|NDUFB6]]|0.432|
|[[:human genes:f:fastkd5|FASTKD5]]|0.432|
|[[:human genes:m:mrps9|MRPS9]]|0.429|
|[[:human genes:r:rpusd4|RPUSD4]]|0.429|
|[[:human genes:p:pars2|PARS2]]|0.429|
|[[:human genes:e:ears2|EARS2]]|0.428|
|[[:human genes:p:pdss1|PDSS1]]|0.427|
|[[:human genes:s:sars2|SARS2]]|0.422|
|[[:human genes:m:mrp63|MRP63]]|0.42|
|[[:human genes:t:trub2|TRUB2]]|0.417|
|[[:human genes:m:mrpl23|MRPL23]]|0.415|
|[[:human genes:m:mrpl12|MRPL12]]|0.413|
|[[:human genes:m:mrps6|MRPS6]]|0.412|
|[[:human genes:m:mterfd2|MTERFD2]]|0.411|
|[[:human genes:c:c17orf89|C17orf89]]|0.408|
|[[:human genes:n:ndufs2|NDUFS2]]|0.408|
|[[:human genes:n:ndufa1|NDUFA1]]|0.407|
|[[:human genes:g:gfm2|GFM2]]|0.406|
|[[:human genes:n:ndufb9|NDUFB9]]|0.405|
|[[:human genes:s:sco2|SCO2]]|0.405|
|[[:human genes:w:wbscr16|WBSCR16]]|0.402|
|[[:human genes:c:c10orf2|C10orf2]]|0.402|
|[[:human genes:s:selrc1|SELRC1]]|0.402|
|[[:human genes:m:mrpl45|MRPL45]]|0.401|
|[[:human genes:m:mrpl33|MRPL33]]|0.4|
|[[:human genes:m:mrps7|MRPS7]]|0.4|
|[[:human genes:m:mettl17|METTL17]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6639
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS17 Expression in NALM6 Cells: 4.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>