======= MRPS23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS23
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51649|51649]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3D9|Q9Y3D9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611985|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRP-S23|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosome|
|intermediate filament cytoskeleton|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|nuclear membrane|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|1.75|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.79|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.8|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.84|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.88|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.95|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.97|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.09|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrp63|MRP63]]|0.63|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.591|
|[[:human genes:m:mrpl21|MRPL21]]|0.586|
|[[:human genes:c:cox16|COX16]]|0.569|
|[[:human genes:v:vars2|VARS2]]|0.568|
|[[:human genes:m:mrps14|MRPS14]]|0.567|
|[[:human genes:g:gfm1|GFM1]]|0.566|
|[[:human genes:d:dap3|DAP3]]|0.566|
|[[:human genes:r:rpusd4|RPUSD4]]|0.563|
|[[:human genes:m:mrps6|MRPS6]]|0.551|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.55|
|[[:human genes:y:yars2|YARS2]]|0.546|
|[[:human genes:q:qrsl1|QRSL1]]|0.545|
|[[:human genes:n:ndufa3|NDUFA3]]|0.545|
|[[:human genes:m:mrpl23|MRPL23]]|0.544|
|[[:human genes:t:tars2|TARS2]]|0.538|
|[[:human genes:p:pars2|PARS2]]|0.534|
|[[:human genes:f:fars2|FARS2]]|0.529|
|[[:human genes:m:mrps9|MRPS9]]|0.528|
|[[:human genes:h:hars2|HARS2]]|0.527|
|[[:human genes:s:sco2|SCO2]]|0.527|
|[[:human genes:e:ears2|EARS2]]|0.526|
|[[:human genes:d:dars2|DARS2]]|0.526|
|[[:human genes:s:selrc1|SELRC1]]|0.525|
|[[:human genes:b:bcs1l|BCS1L]]|0.525|
|[[:human genes:n:nars2|NARS2]]|0.524|
|[[:human genes:m:mrps16|MRPS16]]|0.522|
|[[:human genes:w:wbscr16|WBSCR16]]|0.522|
|[[:human genes:c:coq2|COQ2]]|0.522|
|[[:human genes:p:pnpt1|PNPT1]]|0.52|
|[[:human genes:s:sars2|SARS2]]|0.519|
|[[:human genes:m:mrps21|MRPS21]]|0.51|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.508|
|[[:human genes:l:lars2|LARS2]]|0.507|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.507|
|[[:human genes:t:tufm|TUFM]]|0.505|
|[[:human genes:m:mrps34|MRPS34]]|0.504|
|[[:human genes:m:mrps18a|MRPS18A]]|0.503|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.501|
|[[:human genes:m:mrpl15|MRPL15]]|0.501|
|[[:human genes:m:mrps10|MRPS10]]|0.499|
|[[:human genes:g:gfm2|GFM2]]|0.499|
|[[:human genes:m:mrps26|MRPS26]]|0.498|
|[[:human genes:m:mrps5|MRPS5]]|0.498|
|[[:human genes:m:mrps25|MRPS25]]|0.497|
|[[:human genes:m:mrpl47|MRPL47]]|0.496|
|[[:human genes:c:c12orf65|C12orf65]]|0.496|
|[[:human genes:c:cox7b|COX7B]]|0.494|
|[[:human genes:m:mrps7|MRPS7]]|0.493|
|[[:human genes:w:wars2|WARS2]]|0.49|
|[[:human genes:p:polg2|POLG2]]|0.488|
|[[:human genes:m:mrpl20|MRPL20]]|0.486|
|[[:human genes:c:c10orf2|C10orf2]]|0.484|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.484|
|[[:human genes:m:mettl17|METTL17]]|0.483|
|[[:human genes:m:mrpl42|MRPL42]]|0.483|
|[[:human genes:r:rars2|RARS2]]|0.482|
|[[:human genes:t:tfam|TFAM]]|0.482|
|[[:human genes:n:ndufa1|NDUFA1]]|0.477|
|[[:human genes:n:ndufb11|NDUFB11]]|0.477|
|[[:human genes:m:mrpl44|MRPL44]]|0.476|
|[[:human genes:n:ndufc2|NDUFC2]]|0.476|
|[[:human genes:m:mrpl45|MRPL45]]|0.476|
|[[:human genes:n:ndufs7|NDUFS7]]|0.475|
|[[:human genes:m:mrpl53|MRPL53]]|0.475|
|[[:human genes:m:mrpl39|MRPL39]]|0.475|
|[[:human genes:f:fastkd5|FASTKD5]]|0.474|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.473|
|[[:human genes:a:aars2|AARS2]]|0.473|
|[[:human genes:c:chchd4|CHCHD4]]|0.473|
|[[:human genes:t:trub2|TRUB2]]|0.471|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.471|
|[[:human genes:m:mrpl22|MRPL22]]|0.467|
|[[:human genes:s:slc25a26|SLC25A26]]|0.465|
|[[:human genes:m:mrps24|MRPS24]]|0.464|
|[[:human genes:m:mrps11|MRPS11]]|0.463|
|[[:human genes:m:mrpl36|MRPL36]]|0.462|
|[[:human genes:r:rbfa|RBFA]]|0.461|
|[[:human genes:m:mrpl33|MRPL33]]|0.459|
|[[:human genes:f:ftsj2|FTSJ2]]|0.457|
|[[:human genes:m:mrpl4|MRPL4]]|0.454|
|[[:human genes:a:atp5d|ATP5D]]|0.453|
|[[:human genes:m:mrpl55|MRPL55]]|0.452|
|[[:human genes:a:atp5a1|ATP5A1]]|0.45|
|[[:human genes:n:ndufa2|NDUFA2]]|0.45|
|[[:human genes:m:mrpl3|MRPL3]]|0.447|
|[[:human genes:t:tefm|TEFM]]|0.447|
|[[:human genes:p:pet112|PET112]]|0.446|
|[[:human genes:m:mtg2|MTG2]]|0.446|
|[[:human genes:m:mterfd2|MTERFD2]]|0.444|
|[[:human genes:t:tfb1m|TFB1M]]|0.443|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.442|
|[[:human genes:n:ndufv1|NDUFV1]]|0.442|
|[[:human genes:c:cox15|COX15]]|0.442|
|[[:human genes:m:mars2|MARS2]]|0.44|
|[[:human genes:c:coa6|COA6]]|0.436|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.434|
|[[:human genes:m:mrpl13|MRPL13]]|0.434|
|[[:human genes:p:pet117|PET117]]|0.433|
|[[:human genes:n:ndufb9|NDUFB9]]|0.432|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.432|
|[[:human genes:p:pdss1|PDSS1]]|0.432|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.429|
|[[:human genes:n:ndufa11|NDUFA11]]|0.427|
|[[:human genes:m:mrps33|MRPS33]]|0.426|
|[[:human genes:l:lrpprc|LRPPRC]]|0.426|
|[[:human genes:m:mrps2|MRPS2]]|0.421|
|[[:human genes:p:pitrm1|PITRM1]]|0.42|
|[[:human genes:m:mtpap|MTPAP]]|0.419|
|[[:human genes:c:cox11|COX11]]|0.418|
|[[:human genes:n:ndufs1|NDUFS1]]|0.417|
|[[:human genes:c:coa5|COA5]]|0.417|
|[[:human genes:c:c17orf89|C17orf89]]|0.417|
|[[:human genes:m:mtif3|MTIF3]]|0.415|
|[[:human genes:a:atp5e|ATP5E]]|0.414|
|[[:human genes:m:mrps28|MRPS28]]|0.414|
|[[:human genes:a:atp5c1|ATP5C1]]|0.414|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.413|
|[[:human genes:t:triap1|TRIAP1]]|0.412|
|[[:human genes:i:iba57|IBA57]]|0.412|
|[[:human genes:t:tomm6|TOMM6]]|0.412|
|[[:human genes:c:coq4|COQ4]]|0.411|
|[[:human genes:c:coa3|COA3]]|0.41|
|[[:human genes:g:gatc|GATC]]|0.41|
|[[:human genes:t:tomm22|TOMM22]]|0.409|
|[[:human genes:c:cox6c|COX6C]]|0.408|
|[[:human genes:n:ndufb5|NDUFB5]]|0.407|
|[[:human genes:e:elac2|ELAC2]]|0.406|
|[[:human genes:a:atp5b|ATP5B]]|0.404|
|[[:human genes:m:mrpl52|MRPL52]]|0.404|
|[[:human genes:h:hccs|HCCS]]|0.403|
|[[:human genes:m:mrpl12|MRPL12]]|0.402|
|[[:human genes:r:rpusd3|RPUSD3]]|0.402|
|[[:human genes:t:tomm20|TOMM20]]|0.402|
|[[:human genes:s:ssbp1|SSBP1]]|0.402|
|[[:human genes:d:dhrsx|DHRSX]]|0.401|
|[[:human genes:c:cars2|CARS2]]|0.401|
|[[:human genes:t:tomm7|TOMM7]]|0.4|
|[[:human genes:g:grsf1|GRSF1]]|0.4|
|[[:human genes:c:chchd1|CHCHD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 347/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|15/28|
|bone|13/26|
|breast|18/33|
|central nervous system|20/56|
|cervix|4/4|
|colorectal|11/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|7/21|
|liver|10/20|
|lung|33/75|
|lymphocyte|9/16|
|ovary|7/26|
|pancreas|9/24|
|peripheral nervous system|8/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|15/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1758
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS23 Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>