======= MS4A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MS4A1
  * **<color #00a2e8>Official Name</color>**: membrane spanning 4-domains A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=931|931]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11836|P11836]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MS4A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MS4A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/112210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This protein may be involved in the regulation of B-cell activation and proliferation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CD20|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immunoglobulin binding|
|store-operated calcium entry|
|calcium ion import into cytosol|
|MHC class II protein complex binding|
|plasma membrane raft|
|epidermal growth factor receptor binding|
|B cell proliferation|
|calcium ion import|
|calcium ion transport into cytosol|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|cytosolic calcium ion transport|
|leukocyte proliferation|
|B cell differentiation|
|B cell receptor signaling pathway|
|protein tetramerization|
|B cell activation|
|lymphocyte differentiation|
|calcium ion transport|
|positive regulation of cytosolic calcium ion concentration|
|antigen receptor-mediated signaling pathway|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|humoral immune response|
|lymphocyte activation|
|external side of plasma membrane|
|cellular calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|immune response-regulating cell surface receptor signaling pathway|
|divalent inorganic cation homeostasis|
|protein complex oligomerization|
|cell population proliferation|
|cellular metal ion homeostasis|
|hemopoiesis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|hematopoietic or lymphoid organ development|
|cell surface|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|immune system development|
|response to bacterium|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|positive regulation of immune response|
|cellular homeostasis|
|leukocyte activation|
|cell activation|
|chemical homeostasis|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|ion transport|
|integral component of plasma membrane|
|protein-containing complex assembly|
|extracellular space|
|homeostatic process|
|regulation of immune system process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16289
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MS4A1 Expression in NALM6 Cells: 2.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>