======= MSH3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MSH3
  * **<color #00a2e8>Official Name</color>**: mutS homolog 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4437|4437]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20585|P20585]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MSH3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MSH3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600887|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MutS V|
|MutS I|
|MutS III|
|MutS II|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA insertion or deletion binding|
|removal of nonhomologous ends|
|MutSbeta complex|
|dinucleotide repeat insertion binding|
|meiotic mismatch repair|
|single guanine insertion binding|
|dinucleotide insertion or deletion binding|
|guanine/thymine mispair binding|
|replication fork arrest|
|maintenance of DNA repeat elements|
|positive regulation of helicase activity|
|oxidized purine DNA binding|
|mismatched DNA binding|
|regulation of helicase activity|
|mismatch repair complex|
|mitotic recombination|
|somatic recombination of immunoglobulin gene segments|
|negative regulation of DNA-dependent DNA replication|
|mismatch repair|
|somatic diversification of immunoglobulins|
|somatic cell DNA recombination|
|somatic diversification of immune receptors via germline recombination within a single locus|
|negative regulation of DNA replication|
|DNA-dependent DNA replication maintenance of fidelity|
|DNA-dependent ATPase activity|
|negative regulation of DNA recombination|
|somatic diversification of immune receptors|
|reciprocal meiotic recombination|
|homologous recombination|
|regulation of DNA-dependent DNA replication|
|positive regulation of ATPase activity|
|regulation of ATPase activity|
|regulation of DNA recombination|
|single-stranded DNA binding|
|regulation of DNA replication|
|meiosis I|
|meiosis I cell cycle process|
|DNA-dependent DNA replication|
|negative regulation of DNA metabolic process|
|meiotic nuclear division|
|immunoglobulin production|
|meiotic cell cycle process|
|production of molecular mediator of immune response|
|DNA replication|
|DNA recombination|
|meiotic cell cycle|
|nuclear division|
|organelle fission|
|enzyme binding|
|regulation of DNA metabolic process|
|DNA repair|
|immune system development|
|DNA metabolic process|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|protein homodimerization activity|
|cell cycle process|
|chromosome organization|
|regulation of hydrolase activity|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.06|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.81|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.75|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.75|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.84|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.88|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.02|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9284
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MSH3 Expression in NALM6 Cells: 4.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>