======= MSI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MSI2
  * **<color #00a2e8>Official Name</color>**: musashi RNA binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=124540|124540]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DH6|Q96DH6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MSI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MSI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607897|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|poly(U) RNA binding|
|polysome|
|stem cell development|
|ribonucleoprotein complex|
|stem cell differentiation|
|RNA binding|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-3.85|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-3.83|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-3.62|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-3.57|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.49|
|[[:results:exp274|Citral 50μM R06 exp274]]|-3.41|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-3.4|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-3.3|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-3.23|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-3.15|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-3.08|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-3.06|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-3.05|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.97|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.96|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.94|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.92|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.92|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.89|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.86|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.83|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.82|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.8|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.77|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.74|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.7|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.7|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.65|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.63|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.62|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.62|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.61|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.61|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.6|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.59|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.55|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.53|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.51|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.5|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.49|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.47|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.47|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.46|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.43|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.42|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.42|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.38|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.37|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.37|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.36|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.35|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.33|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.32|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.26|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-2.19|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.18|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.12|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.08|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.04|
|[[:results:exp539|42°C R08 exp539]]|-2.03|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.01|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.99|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.99|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.98|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.98|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.97|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.96|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.96|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.95|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.92|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.91|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.91|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.9|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.9|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.89|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.89|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.88|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.87|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.87|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.86|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.84|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.82|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.81|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.8|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.79|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.77|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.76|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.74|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.73|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.73|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.72|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.72|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.71|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.7|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.73|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.83|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.85|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.87|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.88|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.2|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.23|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zfp36l2|ZFP36L2]]|0.445|
|[[:human genes:n:nprl2|NPRL2]]|0.43|
|[[:human genes:e:eif4b|EIF4B]]|0.423|
|[[:human genes:s:strbp|STRBP]]|0.412|
|[[:human genes:p:pcgf1|PCGF1]]|0.405|
|[[:human genes:t:txnip|TXNIP]]|0.404|
|[[:human genes:t:tcf3|TCF3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19073
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MSI2 Expression in NALM6 Cells: 8.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>