======= MSL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MSL2
  * **<color #00a2e8>Official Name</color>**: MSL complex subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55167|55167]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCI7|Q9HCI7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MSL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MSL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614802|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. {ECO:0000269|PubMed:21726816}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MSL complex|
|histone H4-K16 acetylation|
|histone H4 acetylation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein acylation|
|ubiquitin protein ligase activity|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|protein ubiquitination|
|chromatin organization|
|protein modification by small protein conjugation|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|chromosome organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.64|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.43|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.36|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.27|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.22|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.2|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.12|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.09|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.98|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.93|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.88|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.84|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.82|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.8|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.78|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.78|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.78|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.73|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.72|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.7|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.04|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.33|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|3.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17532
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MSL2 Expression in NALM6 Cells: 6.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>