======= MSN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MSN
  * **<color #00a2e8>Official Name</color>**: moesin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4478|4478]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26038|P26038]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MSN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MSN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/309845|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation (PubMed:27405666). {ECO:0000269|PubMed:21549406, ECO:0000269|PubMed:27405666}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ERM|
|FERM N|
|FERM M|
|FERM C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|T cell aggregation|
|lymphocyte aggregation|
|membrane to membrane docking|
|positive regulation of early endosome to late endosome transport|
|regulation of protein localization to early endosome|
|cellular response to testosterone stimulus|
|positive regulation of protein localization to early endosome|
|invadopodium|
|leukocyte aggregation|
|positive regulation of protein localization to endosome|
|uropod|
|positive regulation of podosome assembly|
|regulation of protein localization to endosome|
|positive regulation of cytoplasmic transport|
|immunological synapse formation|
|regulation of podosome assembly|
|establishment of epithelial cell apical/basal polarity|
|regulation of early endosome to late endosome transport|
|pseudopodium|
|polarized epithelial cell differentiation|
|establishment of apical/basal cell polarity|
|establishment of monopolar cell polarity|
|microvillus membrane|
|establishment or maintenance of monopolar cell polarity|
|regulation of cytoplasmic transport|
|T cell migration|
|establishment of epithelial cell polarity|
|establishment of endothelial barrier|
|response to testosterone|
|T cell proliferation|
|cell periphery|
|morphogenesis of a polarized epithelium|
|interleukin-12-mediated signaling pathway|
|establishment or maintenance of epithelial cell apical/basal polarity|
|cellular response to interleukin-12|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|response to interleukin-12|
|leukocyte cell-cell adhesion|
|endothelial cell development|
|cell adhesion molecule binding|
|regulation of lymphocyte migration|
|microvillus|
|lymphocyte migration|
|cell-cell recognition|
|apical part of cell|
|double-stranded RNA binding|
|filopodium|
|positive regulation of organelle assembly|
|endothelial cell differentiation|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|cellular response to ketone|
|endothelium development|
|leukocyte proliferation|
|gland morphogenesis|
|structural constituent of cytoskeleton|
|establishment of cell polarity|
|positive regulation of cellular protein catabolic process|
|vesicle|
|blood microparticle|
|regulation of cell shape|
|membrane docking|
|regulation of cell size|
|epithelial cell development|
|response to ketone|
|regulation of leukocyte migration|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|positive regulation of intracellular transport|
|positive regulation of protein catabolic process|
|regulation of organelle assembly|
|T cell activation|
|cell recognition|
|regulation of cellular protein catabolic process|
|positive regulation of protein complex assembly|
|actin binding|
|apical plasma membrane|
|positive regulation of cellular protein localization|
|signaling receptor binding|
|enzyme binding|
|regulation of intracellular transport|
|positive regulation of cellular catabolic process|
|cytoskeleton|
|regulation of cellular component size|
|leukocyte migration|
|lymphocyte activation|
|regulation of protein catabolic process|
|gland development|
|focal adhesion|
|positive regulation of catabolic process|
|morphogenesis of an epithelium|
|regulation of protein complex assembly|
|protein kinase binding|
|regulation of cell morphogenesis|
|cell-cell adhesion|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|tissue morphogenesis|
|cellular response to hormone stimulus|
|cell surface|
|positive regulation of organelle organization|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|perinuclear region of cytoplasm|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|regulation of cell migration|
|response to lipid|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of locomotion|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|locomotion|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|cell development|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.14|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9639
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MSN Expression in NALM6 Cells: 8.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>