======= MST1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MST1
  * **<color #00a2e8>Official Name</color>**: macrophage stimulating 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4485|4485]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26927|P26927]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MST1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MST1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142408|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kringle|
|PAN 1|
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mammary gland epithelial cell proliferation|
|hepatocyte growth factor receptor signaling pathway|
|regulation of cAMP-dependent protein kinase activity|
|negative regulation of gluconeogenesis|
|regulation of mammary gland epithelial cell proliferation|
|regulation of macrophage chemotaxis|
|regulation of macrophage migration|
|negative regulation of cellular carbohydrate metabolic process|
|regulation of gluconeogenesis|
|negative regulation of carbohydrate metabolic process|
|receptor tyrosine kinase binding|
|negative regulation of small molecule metabolic process|
|regulation of carbohydrate biosynthetic process|
|regulation of leukocyte chemotaxis|
|regulation of glucose metabolic process|
|regulation of cellular carbohydrate metabolic process|
|serine-type endopeptidase activity|
|positive regulation of epithelial cell proliferation|
|regulation of leukocyte migration|
|regulation of carbohydrate metabolic process|
|regulation of chemotaxis|
|regulation of epithelial cell proliferation|
|collagen-containing extracellular matrix|
|regulation of small molecule metabolic process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|enzyme linked receptor protein signaling pathway|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of response to external stimulus|
|proteolysis|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|extracellular space|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 66/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|5/28|
|bone|5/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|3/20|
|lung|8/75|
|lymphocyte|3/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3096
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MST1 Expression in NALM6 Cells: 2.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>