======= MSTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MSTN
  * **<color #00a2e8>Official Name</color>**: myostatin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2660|2660]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14793|O14793]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MSTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MSTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601788|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts specifically as a negative regulator of skeletal muscle growth. {ECO:0000250|UniProtKB:O08689}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGF beta|
|TGFb propeptide|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of skeletal muscle tissue growth|
|negative regulation of myoblast proliferation|
|negative regulation of skeletal muscle cell proliferation|
|myoblast migration involved in skeletal muscle regeneration|
|negative regulation of skeletal muscle satellite cell proliferation|
|negative regulation of satellite cell differentiation|
|regulation of skeletal muscle tissue growth|
|negative regulation of skeletal muscle cell differentiation|
|skeletal muscle atrophy|
|striated muscle atrophy|
|muscle atrophy|
|response to gravity|
|negative regulation of skeletal muscle tissue development|
|skeletal muscle adaptation|
|regulation of myoblast proliferation|
|regulation of skeletal muscle satellite cell proliferation|
|myoblast migration|
|regulation of skeletal muscle cell proliferation|
|positive regulation of macrophage chemotaxis|
|regulation of skeletal muscle cell differentiation|
|positive regulation of macrophage migration|
|positive regulation of lamellipodium assembly|
|muscle cell cellular homeostasis|
|muscle cell migration|
|response to muscle activity|
|negative regulation of myoblast differentiation|
|regulation of macrophage chemotaxis|
|striated muscle adaptation|
|negative regulation of muscle hypertrophy|
|positive regulation of lamellipodium organization|
|cellular response to dexamethasone stimulus|
|regulation of lamellipodium assembly|
|muscle adaptation|
|negative regulation of insulin receptor signaling pathway|
|skeletal muscle tissue regeneration|
|negative regulation of cellular response to insulin stimulus|
|regulation of macrophage migration|
|response to testosterone|
|response to dexamethasone|
|regulation of lamellipodium organization|
|transforming growth factor beta receptor binding|
|regulation of granulocyte chemotaxis|
|ovulation cycle process|
|response to electrical stimulus|
|regulation of mononuclear cell migration|
|negative regulation of protein kinase B signaling|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of striated muscle tissue development|
|regulation of skeletal muscle tissue development|
|negative regulation of muscle organ development|
|negative regulation of muscle tissue development|
|regulation of myoblast differentiation|
|cellular response to glucocorticoid stimulus|
|SMAD protein signal transduction|
|regulation of muscle hypertrophy|
|cellular response to corticosteroid stimulus|
|regulation of pathway-restricted SMAD protein phosphorylation|
|tissue regeneration|
|regulation of insulin receptor signaling pathway|
|response to activity|
|ovulation cycle|
|regulation of cellular response to insulin stimulus|
|response to estrogen|
|positive regulation of leukocyte chemotaxis|
|cellular response to ketone|
|response to antineoplastic agent|
|positive regulation of plasma membrane bounded cell projection assembly|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of developmental growth|
|response to heat|
|regulation of leukocyte chemotaxis|
|response to ethanol|
|positive regulation of leukocyte migration|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of chemotaxis|
|response to glucocorticoid|
|cellular response to transforming growth factor beta stimulus|
|regeneration|
|response to corticosteroid|
|response to transforming growth factor beta|
|growth factor activity|
|heparin binding|
|cytokine activity|
|response to temperature stimulus|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|response to ketone|
|regulation of leukocyte migration|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of chemotaxis|
|regulation of protein kinase B signaling|
|response to alcohol|
|regulation of muscle system process|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of growth|
|negative regulation of kinase activity|
|rhythmic process|
|negative regulation of transferase activity|
|muscle organ development|
|muscle system process|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to steroid hormone|
|regulation of developmental growth|
|signaling receptor binding|
|anatomical structure homeostasis|
|positive regulation of cell projection organization|
|developmental growth|
|growth|
|cellular response to drug|
|negative regulation of phosphorylation|
|muscle structure development|
|wound healing|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|response to wounding|
|regulation of system process|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.92|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.8|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.71|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.492|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18009
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MSTN Expression in NALM6 Cells: -0.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>