======= MSX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MSX2
  * **<color #00a2e8>Official Name</color>**: msh homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4488|4488]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35548|P35548]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MSX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MSX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123101|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:12145306}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mesenchymal cell apoptotic process|
|activation of meiosis|
|positive regulation of timing of catagen|
|embryonic nail plate morphogenesis|
|frontal suture morphogenesis|
|regulation of timing of catagen|
|positive regulation of hair follicle maturation|
|BMP signaling pathway involved in heart development|
|negative regulation of CREB transcription factor activity|
|bone trabecula formation|
|negative regulation of keratinocyte differentiation|
|regulation of hair follicle maturation|
|cranial suture morphogenesis|
|wound healing, spreading of epidermal cells|
|nail development|
|bone trabecula morphogenesis|
|enamel mineralization|
|positive regulation of hair follicle development|
|regulation of mesenchymal cell apoptotic process|
|positive regulation of hair cycle|
|epithelial to mesenchymal transition involved in endocardial cushion formation|
|positive regulation of meiotic nuclear division|
|regulation of transcription from RNA polymerase II promoter involved in heart development|
|negative regulation of epidermal cell differentiation|
|tooth mineralization|
|craniofacial suture morphogenesis|
|negative regulation of epidermis development|
|osteoblast development|
|regulation of hair follicle development|
|endocardial cushion formation|
|signal transduction involved in regulation of gene expression|
|negative regulation of transcription regulatory region DNA binding|
|amelogenesis|
|trabecula formation|
|branching involved in mammary gland duct morphogenesis|
|cell surface receptor signaling pathway involved in heart development|
|positive regulation of meiotic cell cycle|
|wound healing, spreading of cells|
|epiboly involved in wound healing|
|epiboly|
|cardiac epithelial to mesenchymal transition|
|regulation of hair cycle|
|embryonic hindlimb morphogenesis|
|outflow tract septum morphogenesis|
|mammary gland duct morphogenesis|
|regulation of meiotic nuclear division|
|positive regulation of BMP signaling pathway|
|embryonic forelimb morphogenesis|
|endocardial cushion morphogenesis|
|hindlimb morphogenesis|
|cellular response to estradiol stimulus|
|positive regulation of epidermis development|
|regulation of keratinocyte differentiation|
|forelimb morphogenesis|
|negative regulation of epithelial cell differentiation|
|endochondral bone growth|
|endocardial cushion development|
|mammary gland morphogenesis|
|chondrocyte development|
|bone growth|
|trabecula morphogenesis|
|negative regulation of fat cell differentiation|
|morphogenesis of an epithelial sheet|
|regulation of meiotic cell cycle|
|mesenchyme morphogenesis|
|regulation of transcription regulatory region DNA binding|
|negative regulation of DNA binding|
|mammary gland epithelium development|
|positive regulation of osteoblast differentiation|
|regulation of epidermal cell differentiation|
|embryonic digit morphogenesis|
|cranial skeletal system development|
|positive regulation of nuclear division|
|epithelial to mesenchymal transition|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|positive regulation of reproductive process|
|transcription coregulator activity|
|odontogenesis of dentin-containing tooth|
|chondrocyte differentiation|
|positive regulation of ossification|
|regulation of epidermis development|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|biomineralization|
|biomineral tissue development|
|organ growth|
|gland morphogenesis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to BMP|
|cellular response to BMP stimulus|
|cardiac septum development|
|regulation of osteoblast differentiation|
|bone morphogenesis|
|odontogenesis|
|regulation of fat cell differentiation|
|embryonic limb morphogenesis|
|regulation of DNA binding|
|embryonic appendage morphogenesis|
|cardiac chamber morphogenesis|
|osteoblast differentiation|
|mammary gland development|
|branching morphogenesis of an epithelial tube|
|response to estradiol|
|regulation of epithelial cell differentiation|
|appendage morphogenesis|
|limb morphogenesis|
|mesenchymal cell differentiation|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|negative regulation of DNA-binding transcription factor activity|
|regulation of reproductive process|
|morphogenesis of a branching structure|
|cardiac chamber development|
|negative regulation of binding|
|cartilage development|
|appendage development|
|limb development|
|regulation of ossification|
|regulation of nuclear division|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|anterior/posterior pattern specification|
|transcription regulatory region DNA binding|
|mesenchyme development|
|connective tissue development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|heart morphogenesis|
|ossification|
|regulation of cellular response to growth factor stimulus|
|positive regulation of cell cycle process|
|epithelial tube morphogenesis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|transcription factor binding|
|regionalization|
|positive regulation of cell cycle|
|regulation of binding|
|developmental growth|
|growth|
|nuclear speck|
|gland development|
|sequence-specific DNA binding|
|regulation of DNA-binding transcription factor activity|
|morphogenesis of an epithelium|
|pattern specification process|
|wound healing|
|skeletal system development|
|cellular response to growth factor stimulus|
|cellular response to lipid|
|heart development|
|response to growth factor|
|cellular response to organic cyclic compound|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of cell cycle process|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|negative regulation of cell death|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|epithelium development|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MSX2 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>