======= MTG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTG2
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosome associated GTPase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26164|26164]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4K7|Q9H4K7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610919|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process. {ECO:0000269|PubMed:17054726, ECO:0000269|PubMed:23396448}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FeoB N|
|GTP1 OBG|
|MMR HSR1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of respiratory system process|
|regulation of respiratory gaseous exchange|
|mitochondrial ribosome|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|magnesium ion binding|
|ribosome biogenesis|
|GTPase activity|
|regulation of translation|
|mitochondrial matrix|
|GTP binding|
|mitochondrial inner membrane|
|regulation of cellular amide metabolic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|regulation of system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.01|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.76|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.7|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.72|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.73|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.84|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.87|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.17|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tars2|TARS2]]|0.698|
|[[:human genes:m:mrpl21|MRPL21]]|0.659|
|[[:human genes:m:mrps34|MRPS34]]|0.637|
|[[:human genes:n:nars2|NARS2]]|0.636|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.633|
|[[:human genes:m:mrps6|MRPS6]]|0.629|
|[[:human genes:q:qrsl1|QRSL1]]|0.624|
|[[:human genes:p:pars2|PARS2]]|0.623|
|[[:human genes:r:rpusd4|RPUSD4]]|0.621|
|[[:human genes:m:mrps5|MRPS5]]|0.619|
|[[:human genes:y:yars2|YARS2]]|0.618|
|[[:human genes:e:ears2|EARS2]]|0.618|
|[[:human genes:m:mrpl23|MRPL23]]|0.612|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.61|
|[[:human genes:c:cox16|COX16]]|0.608|
|[[:human genes:s:sco2|SCO2]]|0.608|
|[[:human genes:m:mrps16|MRPS16]]|0.607|
|[[:human genes:s:selrc1|SELRC1]]|0.606|
|[[:human genes:f:fastkd5|FASTKD5]]|0.605|
|[[:human genes:m:mrpl47|MRPL47]]|0.603|
|[[:human genes:d:dap3|DAP3]]|0.599|
|[[:human genes:m:mrps21|MRPS21]]|0.592|
|[[:human genes:m:mrp63|MRP63]]|0.587|
|[[:human genes:a:aars2|AARS2]]|0.576|
|[[:human genes:g:gfm1|GFM1]]|0.572|
|[[:human genes:m:mrpl45|MRPL45]]|0.57|
|[[:human genes:p:pet112|PET112]]|0.567|
|[[:human genes:h:hars2|HARS2]]|0.567|
|[[:human genes:m:mrps14|MRPS14]]|0.566|
|[[:human genes:m:mtpap|MTPAP]]|0.562|
|[[:human genes:m:mrps25|MRPS25]]|0.562|
|[[:human genes:l:lars2|LARS2]]|0.561|
|[[:human genes:m:mrpl53|MRPL53]]|0.558|
|[[:human genes:c:chchd1|CHCHD1]]|0.557|
|[[:human genes:m:mrps2|MRPS2]]|0.554|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.554|
|[[:human genes:g:gfm2|GFM2]]|0.551|
|[[:human genes:s:sars2|SARS2]]|0.55|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.549|
|[[:human genes:m:mrpl44|MRPL44]]|0.548|
|[[:human genes:c:coa3|COA3]]|0.547|
|[[:human genes:n:ndufb11|NDUFB11]]|0.546|
|[[:human genes:v:vars2|VARS2]]|0.546|
|[[:human genes:r:rars2|RARS2]]|0.545|
|[[:human genes:c:c12orf65|C12orf65]]|0.544|
|[[:human genes:r:rbfa|RBFA]]|0.543|
|[[:human genes:m:mtg1|MTG1]]|0.537|
|[[:human genes:m:mrps12|MRPS12]]|0.535|
|[[:human genes:m:mrps9|MRPS9]]|0.533|
|[[:human genes:m:mrps26|MRPS26]]|0.532|
|[[:human genes:b:bcs1l|BCS1L]]|0.531|
|[[:human genes:m:mrps24|MRPS24]]|0.527|
|[[:human genes:n:ndufa3|NDUFA3]]|0.527|
|[[:human genes:w:wbscr16|WBSCR16]]|0.525|
|[[:human genes:c:coa6|COA6]]|0.523|
|[[:human genes:m:mrps18a|MRPS18A]]|0.522|
|[[:human genes:m:malsu1|MALSU1]]|0.521|
|[[:human genes:p:polg2|POLG2]]|0.521|
|[[:human genes:m:mrpl43|MRPL43]]|0.52|
|[[:human genes:m:mrpl12|MRPL12]]|0.52|
|[[:human genes:m:mrpl15|MRPL15]]|0.519|
|[[:human genes:m:mars2|MARS2]]|0.518|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.512|
|[[:human genes:m:mrps35|MRPS35]]|0.512|
|[[:human genes:m:mrpl55|MRPL55]]|0.511|
|[[:human genes:m:mrps10|MRPS10]]|0.51|
|[[:human genes:f:ftsj2|FTSJ2]]|0.509|
|[[:human genes:p:pet117|PET117]]|0.509|
|[[:human genes:c:coq2|COQ2]]|0.508|
|[[:human genes:m:mtif2|MTIF2]]|0.506|
|[[:human genes:m:mrpl3|MRPL3]]|0.504|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.504|
|[[:human genes:p:pdss1|PDSS1]]|0.503|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.503|
|[[:human genes:s:ssbp1|SSBP1]]|0.503|
|[[:human genes:g:gatc|GATC]]|0.501|
|[[:human genes:n:ndufa2|NDUFA2]]|0.499|
|[[:human genes:c:cox7b|COX7B]]|0.496|
|[[:human genes:m:mipep|MIPEP]]|0.494|
|[[:human genes:d:dars2|DARS2]]|0.493|
|[[:human genes:t:trub2|TRUB2]]|0.493|
|[[:human genes:m:mettl17|METTL17]]|0.49|
|[[:human genes:f:fars2|FARS2]]|0.49|
|[[:human genes:s:slc25a26|SLC25A26]]|0.49|
|[[:human genes:e:ecsit|ECSIT]]|0.489|
|[[:human genes:c:cox6c|COX6C]]|0.488|
|[[:human genes:r:rpusd3|RPUSD3]]|0.487|
|[[:human genes:t:tmem261|TMEM261]]|0.484|
|[[:human genes:p:polrmt|POLRMT]]|0.484|
|[[:human genes:p:pnpt1|PNPT1]]|0.483|
|[[:human genes:n:ndufc2|NDUFC2]]|0.482|
|[[:human genes:m:mrpl34|MRPL34]]|0.479|
|[[:human genes:c:cox11|COX11]]|0.479|
|[[:human genes:t:timm8b|TIMM8B]]|0.477|
|[[:human genes:m:mrps22|MRPS22]]|0.477|
|[[:human genes:c:c10orf2|C10orf2]]|0.475|
|[[:human genes:m:mrpl4|MRPL4]]|0.474|
|[[:human genes:a:aifm1|AIFM1]]|0.474|
|[[:human genes:m:mrpl2|MRPL2]]|0.474|
|[[:human genes:g:grsf1|GRSF1]]|0.473|
|[[:human genes:n:ndufb5|NDUFB5]]|0.47|
|[[:human genes:m:mrpl20|MRPL20]]|0.47|
|[[:human genes:f:fastkd2|FASTKD2]]|0.469|
|[[:human genes:w:wars2|WARS2]]|0.468|
|[[:human genes:t:tomm20|TOMM20]]|0.468|
|[[:human genes:p:ptcd1|PTCD1]]|0.466|
|[[:human genes:t:tefm|TEFM]]|0.466|
|[[:human genes:m:mrps33|MRPS33]]|0.465|
|[[:human genes:d:dhx30|DHX30]]|0.465|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.464|
|[[:human genes:a:atp5sl|ATP5SL]]|0.459|
|[[:human genes:m:mrps7|MRPS7]]|0.458|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.458|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.456|
|[[:human genes:m:mterfd2|MTERFD2]]|0.455|
|[[:human genes:c:c17orf89|C17orf89]]|0.454|
|[[:human genes:p:pgm3|PGM3]]|0.454|
|[[:human genes:c:coa5|COA5]]|0.452|
|[[:human genes:t:tfam|TFAM]]|0.451|
|[[:human genes:t:tmem242|TMEM242]]|0.451|
|[[:human genes:c:cox17|COX17]]|0.451|
|[[:human genes:c:coq3|COQ3]]|0.448|
|[[:human genes:n:ndufs2|NDUFS2]]|0.447|
|[[:human genes:m:mrps23|MRPS23]]|0.446|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.445|
|[[:human genes:t:tomm6|TOMM6]]|0.444|
|[[:human genes:t:tufm|TUFM]]|0.443|
|[[:human genes:m:mrpl37|MRPL37]]|0.442|
|[[:human genes:n:ndufb6|NDUFB6]]|0.441|
|[[:human genes:c:chchd4|CHCHD4]]|0.439|
|[[:human genes:m:mrpl11|MRPL11]]|0.435|
|[[:human genes:e:elac2|ELAC2]]|0.433|
|[[:human genes:p:polg|POLG]]|0.432|
|[[:human genes:m:mrpl13|MRPL13]]|0.432|
|[[:human genes:d:ddx28|DDX28]]|0.431|
|[[:human genes:n:ndufs8|NDUFS8]]|0.431|
|[[:human genes:n:ndufb9|NDUFB9]]|0.431|
|[[:human genes:m:mto1|MTO1]]|0.43|
|[[:human genes:n:ndufb7|NDUFB7]]|0.427|
|[[:human genes:m:mtif3|MTIF3]]|0.427|
|[[:human genes:c:coq4|COQ4]]|0.427|
|[[:human genes:m:mrpl32|MRPL32]]|0.426|
|[[:human genes:c:cox15|COX15]]|0.426|
|[[:human genes:n:ndufa11|NDUFA11]]|0.425|
|[[:human genes:i:iba57|IBA57]]|0.425|
|[[:human genes:m:mrps28|MRPS28]]|0.425|
|[[:human genes:m:mrpl1|MRPL1]]|0.424|
|[[:human genes:c:coq7|COQ7]]|0.424|
|[[:human genes:p:pitrm1|PITRM1]]|0.423|
|[[:human genes:e:eral1|ERAL1]]|0.423|
|[[:human genes:o:opa1|OPA1]]|0.421|
|[[:human genes:n:ndufa1|NDUFA1]]|0.42|
|[[:human genes:t:tomm40|TOMM40]]|0.42|
|[[:human genes:m:mrps27|MRPS27]]|0.419|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.419|
|[[:human genes:c:cox6b1|COX6B1]]|0.417|
|[[:human genes:a:acad9|ACAD9]]|0.416|
|[[:human genes:c:cars2|CARS2]]|0.416|
|[[:human genes:m:mrpl33|MRPL33]]|0.415|
|[[:human genes:m:mcat|MCAT]]|0.414|
|[[:human genes:p:ptcd3|PTCD3]]|0.412|
|[[:human genes:m:mrpl42|MRPL42]]|0.412|
|[[:human genes:c:cox5a|COX5A]]|0.411|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.409|
|[[:human genes:n:ndufc1|NDUFC1]]|0.409|
|[[:human genes:r:rpia|RPIA]]|0.408|
|[[:human genes:m:mrpl22|MRPL22]]|0.407|
|[[:human genes:n:ndufs7|NDUFS7]]|0.406|
|[[:human genes:u:uqcr10|UQCR10]]|0.405|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.405|
|[[:human genes:m:mrpl49|MRPL49]]|0.404|
|[[:human genes:m:mrpl35|MRPL35]]|0.404|
|[[:human genes:m:mrpl41|MRPL41]]|0.403|
|[[:human genes:n:ndufb3|NDUFB3]]|0.402|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.401|
|[[:human genes:p:pet100|PET100]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 33/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|3/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|5/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 577
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTG2 Expression in NALM6 Cells: 5.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>