======= MTHFD1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTHFD1L
  * **<color #00a2e8>Official Name</color>**: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25902|25902]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UB35|Q6UB35]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTHFD1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTHFD1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611427|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FTHFS|
|THF DHG CYH C|
|THF DHG CYH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|formate-tetrahydrofolate ligase activity|
|10-formyltetrahydrofolate biosynthetic process|
|methylenetetrahydrofolate dehydrogenase (NADP+) activity|
|10-formyltetrahydrofolate metabolic process|
|formate metabolic process|
|embryonic neurocranium morphogenesis|
|tetrahydrofolate biosynthetic process|
|folic acid-containing compound biosynthetic process|
|embryonic viscerocranium morphogenesis|
|tetrahydrofolate interconversion|
|purine nucleobase biosynthetic process|
|dicarboxylic acid biosynthetic process|
|pteridine-containing compound biosynthetic process|
|tetrahydrofolate metabolic process|
|folic acid metabolic process|
|nucleobase biosynthetic process|
|purine nucleobase metabolic process|
|one-carbon metabolic process|
|folic acid-containing compound metabolic process|
|pteridine-containing compound metabolic process|
|nucleobase metabolic process|
|embryonic cranial skeleton morphogenesis|
|cellular modified amino acid biosynthetic process|
|pigment biosynthetic process|
|pigment metabolic process|
|cranial skeletal system development|
|water-soluble vitamin metabolic process|
|neural tube closure|
|tube closure|
|embryonic skeletal system morphogenesis|
|dicarboxylic acid metabolic process|
|primary neural tube formation|
|antibiotic metabolic process|
|neural tube formation|
|embryonic epithelial tube formation|
|vitamin metabolic process|
|embryonic skeletal system development|
|epithelial tube formation|
|coenzyme biosynthetic process|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|purine-containing compound biosynthetic process|
|cellular modified amino acid metabolic process|
|cofactor biosynthetic process|
|skeletal system morphogenesis|
|coenzyme metabolic process|
|embryonic organ morphogenesis|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|epithelial tube morphogenesis|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|morphogenesis of an epithelium|
|embryonic organ development|
|cofactor metabolic process|
|skeletal system development|
|drug metabolic process|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|small molecule biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|cellular amide metabolic process|
|tube development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|animal organ morphogenesis|
|oxidation-reduction process|
|embryo development|
|oxoacid metabolic process|
|organic acid metabolic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|tissue development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.47|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2.1|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.7|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.74|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.74|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.78|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.85|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.92|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.2|
|[[:results:exp116|AICAR 240μM R03 exp116]]|4.73|
|[[:results:exp211|AICAR 240μM R05 exp211]]|4.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mthfd2|MTHFD2]]|0.661|
|[[:human genes:s:slc25a32|SLC25A32]]|0.654|
|[[:human genes:s:shmt2|SHMT2]]|0.615|
|[[:human genes:m:mtr|MTR]]|0.567|
|[[:human genes:m:mtrr|MTRR]]|0.55|
|[[:human genes:m:mmachc|MMACHC]]|0.456|
|[[:human genes:s:sfxn1|SFXN1]]|0.439|
|[[:human genes:s:slc25a52|SLC25A52]]|0.421|
|[[:human genes:s:slc25a51|SLC25A51]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5693
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTHFD1L Expression in NALM6 Cells: 6.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>