======= MTHFS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTHFS
  * **<color #00a2e8>Official Name</color>**: methenyltetrahydrofolate synthetase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10588|10588]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49914|P49914]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTHFS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTHFS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604197|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate. {ECO:0000269|PubMed:8522195}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|5-FTHF cyc-lig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|folic acid catabolic process|
|5-formyltetrahydrofolate cyclo-ligase activity|
|water-soluble vitamin catabolic process|
|pteridine-containing compound catabolic process|
|folic acid-containing compound catabolic process|
|formate metabolic process|
|folic acid-containing compound biosynthetic process|
|tetrahydrofolate interconversion|
|folic acid binding|
|vitamin catabolic process|
|pteridine-containing compound biosynthetic process|
|coenzyme catabolic process|
|dicarboxylic acid catabolic process|
|tetrahydrofolate metabolic process|
|folic acid metabolic process|
|one-carbon metabolic process|
|folic acid-containing compound metabolic process|
|cellular modified amino acid catabolic process|
|glutamate metabolic process|
|pteridine-containing compound metabolic process|
|cellular modified amino acid biosynthetic process|
|cofactor catabolic process|
|glutamine family amino acid metabolic process|
|water-soluble vitamin metabolic process|
|dicarboxylic acid metabolic process|
|antibiotic metabolic process|
|vitamin metabolic process|
|coenzyme biosynthetic process|
|drug catabolic process|
|cellular modified amino acid metabolic process|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|drug metabolic process|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|small molecule biosynthetic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-2.53|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.05|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.02|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.551|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13758
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTHFS Expression in NALM6 Cells: 3.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>