======= MTIF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTIF2
  * **<color #00a2e8>Official Name</color>**: mitochondrial translational initiation factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4528|4528]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P46199|P46199]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTIF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTIF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603766|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU|
|IF-2|
|GTP EFTU D2|
|Miro|
|MMR HSR1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial translational initiation|
|ribosome disassembly|
|ribonucleoprotein complex disassembly|
|ribosomal small subunit binding|
|translation factor activity, RNA binding|
|translation initiation factor activity|
|organelle disassembly|
|regulation of translational initiation|
|mitochondrial translation|
|mitochondrial gene expression|
|translational initiation|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|GTPase activity|
|regulation of translation|
|translation|
|GTP binding|
|cellular component disassembly|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.73|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.74|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.75|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.76|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.8|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.8|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.87|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.88|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.98|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.01|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.07|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2.1|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.1|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.34|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.53|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fastkd2|FASTKD2]]|0.581|
|[[:human genes:g:grsf1|GRSF1]]|0.58|
|[[:human genes:a:acad9|ACAD9]]|0.577|
|[[:human genes:l:lars2|LARS2]]|0.571|
|[[:human genes:n:nsun4|NSUN4]]|0.569|
|[[:human genes:p:pet112|PET112]]|0.56|
|[[:human genes:p:pet117|PET117]]|0.552|
|[[:human genes:t:tfb1m|TFB1M]]|0.547|
|[[:human genes:m:malsu1|MALSU1]]|0.545|
|[[:human genes:m:mettl17|METTL17]]|0.544|
|[[:human genes:n:nars2|NARS2]]|0.543|
|[[:human genes:m:mrps21|MRPS21]]|0.536|
|[[:human genes:n:ndufb10|NDUFB10]]|0.536|
|[[:human genes:f:ftsj2|FTSJ2]]|0.532|
|[[:human genes:n:nubpl|NUBPL]]|0.529|
|[[:human genes:c:cars2|CARS2]]|0.525|
|[[:human genes:n:ndufc2|NDUFC2]]|0.524|
|[[:human genes:m:mrps35|MRPS35]]|0.523|
|[[:human genes:n:ndufa1|NDUFA1]]|0.523|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.52|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.52|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.516|
|[[:human genes:c:c1qbp|C1QBP]]|0.512|
|[[:human genes:e:ears2|EARS2]]|0.512|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.511|
|[[:human genes:m:mrpl45|MRPL45]]|0.51|
|[[:human genes:t:tsfm|TSFM]]|0.508|
|[[:human genes:r:rpusd3|RPUSD3]]|0.508|
|[[:human genes:m:mto1|MTO1]]|0.508|
|[[:human genes:m:mtg2|MTG2]]|0.506|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.505|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.505|
|[[:human genes:n:ndufs8|NDUFS8]]|0.504|
|[[:human genes:s:sfxn4|SFXN4]]|0.502|
|[[:human genes:r:rmnd1|RMND1]]|0.499|
|[[:human genes:i:ict1|ICT1]]|0.497|
|[[:human genes:n:ndufb11|NDUFB11]]|0.493|
|[[:human genes:p:polg2|POLG2]]|0.493|
|[[:human genes:s:ssbp1|SSBP1]]|0.492|
|[[:human genes:w:wars2|WARS2]]|0.491|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.489|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.488|
|[[:human genes:p:pde12|PDE12]]|0.488|
|[[:human genes:q:qrsl1|QRSL1]]|0.488|
|[[:human genes:a:aars2|AARS2]]|0.485|
|[[:human genes:m:mcat|MCAT]]|0.485|
|[[:human genes:m:mrpl48|MRPL48]]|0.483|
|[[:human genes:n:ndufb7|NDUFB7]]|0.483|
|[[:human genes:r:rars2|RARS2]]|0.482|
|[[:human genes:n:ndufa2|NDUFA2]]|0.481|
|[[:human genes:e:eral1|ERAL1]]|0.481|
|[[:human genes:d:ddx28|DDX28]]|0.481|
|[[:human genes:t:tmem261|TMEM261]]|0.481|
|[[:human genes:n:ndufs2|NDUFS2]]|0.479|
|[[:human genes:p:pars2|PARS2]]|0.475|
|[[:human genes:n:ndufa11|NDUFA11]]|0.475|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.475|
|[[:human genes:m:mrps27|MRPS27]]|0.474|
|[[:human genes:n:ndufb9|NDUFB9]]|0.472|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.471|
|[[:human genes:m:mrpl21|MRPL21]]|0.471|
|[[:human genes:c:cox20|COX20]]|0.47|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.467|
|[[:human genes:c:chchd1|CHCHD1]]|0.467|
|[[:human genes:y:yars2|YARS2]]|0.465|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.464|
|[[:human genes:m:mtg1|MTG1]]|0.463|
|[[:human genes:n:ndufb4|NDUFB4]]|0.463|
|[[:human genes:f:foxred1|FOXRED1]]|0.462|
|[[:human genes:n:noa1|NOA1]]|0.461|
|[[:human genes:m:mrps25|MRPS25]]|0.459|
|[[:human genes:y:ybey|YBEY]]|0.459|
|[[:human genes:c:clpp|CLPP]]|0.457|
|[[:human genes:m:mterfd1|MTERFD1]]|0.456|
|[[:human genes:d:dap3|DAP3]]|0.454|
|[[:human genes:m:mrpl43|MRPL43]]|0.453|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.452|
|[[:human genes:m:mars2|MARS2]]|0.452|
|[[:human genes:g:gfm1|GFM1]]|0.449|
|[[:human genes:p:ptcd3|PTCD3]]|0.449|
|[[:human genes:c:coa6|COA6]]|0.449|
|[[:human genes:g:gfm2|GFM2]]|0.447|
|[[:human genes:s:selrc1|SELRC1]]|0.446|
|[[:human genes:m:mrps6|MRPS6]]|0.445|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.445|
|[[:human genes:c:coq7|COQ7]]|0.443|
|[[:human genes:n:ndufs1|NDUFS1]]|0.443|
|[[:human genes:n:ndufa3|NDUFA3]]|0.442|
|[[:human genes:m:mrps12|MRPS12]]|0.44|
|[[:human genes:n:ndufc1|NDUFC1]]|0.44|
|[[:human genes:t:tars2|TARS2]]|0.439|
|[[:human genes:m:mrpl1|MRPL1]]|0.435|
|[[:human genes:c:cox19|COX19]]|0.434|
|[[:human genes:n:ndufs5|NDUFS5]]|0.431|
|[[:human genes:m:mrpl23|MRPL23]]|0.43|
|[[:human genes:p:polrmt|POLRMT]]|0.429|
|[[:human genes:p:prepl|PREPL]]|0.428|
|[[:human genes:m:mrps16|MRPS16]]|0.424|
|[[:human genes:a:atp5sl|ATP5SL]]|0.424|
|[[:human genes:s:slc25a51|SLC25A51]]|0.424|
|[[:human genes:n:ndufa10|NDUFA10]]|0.422|
|[[:human genes:c:coa3|COA3]]|0.421|
|[[:human genes:c:coq2|COQ2]]|0.419|
|[[:human genes:t:trub2|TRUB2]]|0.419|
|[[:human genes:c:c12orf65|C12orf65]]|0.418|
|[[:human genes:n:ndufa9|NDUFA9]]|0.418|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.418|
|[[:human genes:a:aifm1|AIFM1]]|0.416|
|[[:human genes:m:mrpl3|MRPL3]]|0.416|
|[[:human genes:c:coq6|COQ6]]|0.414|
|[[:human genes:w:wbscr16|WBSCR16]]|0.414|
|[[:human genes:p:ptcd2|PTCD2]]|0.412|
|[[:human genes:e:ecsit|ECSIT]]|0.411|
|[[:human genes:s:slc30a9|SLC30A9]]|0.41|
|[[:human genes:m:mrps18b|MRPS18B]]|0.41|
|[[:human genes:h:hars2|HARS2]]|0.409|
|[[:human genes:n:ndufa13|NDUFA13]]|0.408|
|[[:human genes:m:mrpl40|MRPL40]]|0.406|
|[[:human genes:v:vars2|VARS2]]|0.406|
|[[:human genes:m:mrpl42|MRPL42]]|0.404|
|[[:human genes:m:mdh2|MDH2]]|0.403|
|[[:human genes:m:mrps10|MRPS10]]|0.403|
|[[:human genes:m:mrpl47|MRPL47]]|0.402|
|[[:human genes:m:mrp63|MRP63]]|0.402|
|[[:human genes:f:fastkd5|FASTKD5]]|0.402|
|[[:human genes:m:mrpl12|MRPL12]]|0.401|
|[[:human genes:m:mrps7|MRPS7]]|0.401|
|[[:human genes:m:mrps22|MRPS22]]|0.4|
|[[:human genes:m:mterfd2|MTERFD2]]|0.4|
|[[:human genes:m:mrpl53|MRPL53]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 616
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTIF2 Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>