======= MTNR1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTNR1B
  * **<color #00a2e8>Official Name</color>**: melatonin receptor 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4544|4544]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49286|P49286]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTNR1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTNR1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600804|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srx|
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|melatonin receptor activity|
|positive regulation of circadian sleep/wake cycle, non-REM sleep|
|regulation of neuronal action potential|
|negative regulation of transmission of nerve impulse|
|positive regulation of circadian sleep/wake cycle, sleep|
|negative regulation of cGMP-mediated signaling|
|positive regulation of transmission of nerve impulse|
|regulation of circadian sleep/wake cycle, non-REM sleep|
|negative regulation of delayed rectifier potassium channel activity|
|negative regulation of cytosolic calcium ion concentration|
|negative regulation of voltage-gated potassium channel activity|
|regulation of cGMP-mediated signaling|
|positive regulation of circadian rhythm|
|regulation of circadian sleep/wake cycle, sleep|
|regulation of transmission of nerve impulse|
|regulation of delayed rectifier potassium channel activity|
|negative regulation of potassium ion transmembrane transporter activity|
|regulation of circadian sleep/wake cycle|
|negative regulation of potassium ion transmembrane transport|
|negative regulation of nervous system process|
|positive regulation of behavior|
|negative regulation of potassium ion transport|
|negative regulation of insulin secretion|
|negative regulation of cation channel activity|
|negative regulation of peptide hormone secretion|
|regulation of action potential|
|regulation of potassium ion transmembrane transporter activity|
|positive regulation of blood vessel diameter|
|negative regulation of hormone secretion|
|positive regulation of nervous system process|
|negative regulation of ion transmembrane transporter activity|
|regulation of behavior|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|regulation of circadian rhythm|
|negative regulation of transmembrane transport|
|negative regulation of protein secretion|
|regulation of nervous system process|
|negative regulation of peptide secretion|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|negative regulation of neuron apoptotic process|
|negative regulation of ion transport|
|vascular process in circulatory system|
|regulation of cation channel activity|
|regulation of insulin secretion|
|negative regulation of protein transport|
|glucose homeostasis|
|negative regulation of establishment of protein localization|
|carbohydrate homeostasis|
|negative regulation of secretion by cell|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of peptide hormone secretion|
|negative regulation of secretion|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|regulation of transporter activity|
|regulation of neuron death|
|camera-type eye development|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|eye development|
|visual system development|
|sensory system development|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|regulation of anatomical structure size|
|regulation of hormone levels|
|sensory organ development|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|regulation of protein localization|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.19|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.93|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.85|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.81|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.8|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.78|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.77|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.71|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6531
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTNR1B Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>