======= MTTP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTTP
  * **<color #00a2e8>Official Name</color>**: microsomal triglyceride transfer protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4547|4547]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55157|P55157]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTTP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTTP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/157147|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785). {ECO:0000269|PubMed:22236406, ECO:0000269|PubMed:23475612, ECO:0000269|PubMed:25108285, ECO:0000269|PubMed:26224785, ECO:0000269|PubMed:8939939}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vitellogenin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospholipid transfer activity|
|triglyceride transfer activity|
|acylglycerol transport|
|triglyceride transport|
|ceramide 1-phosphate transport|
|ceramide 1-phosphate transfer activity|
|chylomicron assembly|
|very-low-density lipoprotein particle assembly|
|ceramide transport|
|phospholipid transporter activity|
|plasma lipoprotein particle assembly|
|lipid transporter activity|
|protein-lipid complex assembly|
|plasma lipoprotein particle organization|
|protein-lipid complex subunit organization|
|regulation of plasma lipoprotein particle levels|
|cholesterol homeostasis|
|sterol homeostasis|
|phospholipid transport|
|lipoprotein metabolic process|
|organophosphate ester transport|
|lipid homeostasis|
|lipid binding|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|basolateral plasma membrane|
|receptor complex|
|lipid transport|
|endoplasmic reticulum lumen|
|lipid localization|
|extracellular structure organization|
|organic anion transport|
|protein heterodimerization activity|
|anion transport|
|Golgi apparatus|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|chemical homeostasis|
|secretion|
|lipid metabolic process|
|ion transport|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10718
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTTP Expression in NALM6 Cells: -1.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>