======= MVD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MVD
  * **<color #00a2e8>Official Name</color>**: mevalonate diphosphate decarboxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4597|4597]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53602|P53602]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MVD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MVD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603236|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Performs the first committed step in the biosynthesis of isoprenes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GHMP kinases N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diphosphomevalonate decarboxylase activity|
|isopentenyl diphosphate biosynthetic process, mevalonate pathway|
|isopentenyl diphosphate biosynthetic process|
|isopentenyl diphosphate metabolic process|
|dolichyl diphosphate metabolic process|
|dolichyl diphosphate biosynthetic process|
|dolichol-linked oligosaccharide biosynthetic process|
|oligosaccharide-lipid intermediate biosynthetic process|
|isoprenoid biosynthetic process|
|acetyl-CoA metabolic process|
|Hsp70 protein binding|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|sterol biosynthetic process|
|regulation of cholesterol metabolic process|
|regulation of alcohol biosynthetic process|
|protein N-linked glycosylation|
|regulation of steroid biosynthetic process|
|thioester metabolic process|
|acyl-CoA metabolic process|
|peroxisome|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|sterol metabolic process|
|isoprenoid metabolic process|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|phospholipid biosynthetic process|
|coenzyme metabolic process|
|protein glycosylation|
|macromolecule glycosylation|
|steroid metabolic process|
|glycosylation|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|glycoprotein biosynthetic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|phospholipid metabolic process|
|glycoprotein metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|cellular amide metabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|positive regulation of cell population proliferation|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|regulation of cell population proliferation|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.26|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.21|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.09|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.98|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.95|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.87|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.82|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 375/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|20/28|
|bone|12/26|
|breast|16/33|
|central nervous system|13/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|10/21|
|liver|12/20|
|lung|42/75|
|lymphocyte|5/16|
|ovary|11/26|
|pancreas|18/24|
|peripheral nervous system|10/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|10/22|
|urinary tract|14/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 254
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MVD Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>