======= MYB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYB
  * **<color #00a2e8>Official Name</color>**: MYB proto-oncogene, transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4602|4602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10242|P10242]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Wos2|
|Myb DNA-binding|
|Cmyb C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of hepatic stellate cell proliferation|
|positive regulation of hepatic stellate cell proliferation|
|positive regulation of testosterone secretion|
|regulation of testosterone secretion|
|positive regulation of hepatic stellate cell activation|
|regulation of hepatic stellate cell activation|
|positive regulation of histone H3-K9 methylation|
|positive regulation of glial cell proliferation|
|positive regulation of histone H3-K4 methylation|
|positive regulation of transforming growth factor beta production|
|positive regulation of T-helper cell differentiation|
|regulation of histone H3-K9 methylation|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|regulation of histone H3-K4 methylation|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of glial cell proliferation|
|regulation of T-helper cell differentiation|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|regulation of collagen biosynthetic process|
|regulation of transforming growth factor beta production|
|positive regulation of histone methylation|
|regulation of collagen metabolic process|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of fibroblast proliferation|
|positive regulation of neuron apoptotic process|
|regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of alpha-beta T cell activation|
|positive regulation of lipid transport|
|regulation of alpha-beta T cell differentiation|
|regulation of histone methylation|
|positive regulation of gliogenesis|
|cellular response to retinoic acid|
|cellular response to hydrogen peroxide|
|regulation of hematopoietic stem cell differentiation|
|positive regulation of lipid localization|
|regulation of fibroblast proliferation|
|positive regulation of T cell differentiation|
|positive regulation of smooth muscle cell proliferation|
|regulation of hematopoietic progenitor cell differentiation|
|positive regulation of histone modification|
|positive regulation of neuron death|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of chromatin organization|
|regulation of lipid transport|
|response to retinoic acid|
|nuclear matrix|
|regulation of gliogenesis|
|regulation of stem cell differentiation|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|positive regulation of hormone secretion|
|cellular response to reactive oxygen species|
|regulation of smooth muscle cell proliferation|
|regulation of lipid localization|
|regulation of T cell differentiation|
|regulation of histone modification|
|positive regulation of leukocyte differentiation|
|chromatin remodeling|
|regulation of lymphocyte differentiation|
|positive regulation of chromosome organization|
|positive regulation of hemopoiesis|
|regulation of chromatin organization|
|response to reactive oxygen species|
|positive regulation of T cell activation|
|regulation of neuron apoptotic process|
|cellular response to acid chemical|
|cellular response to toxic substance|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|cellular response to oxidative stress|
|positive regulation of cell-cell adhesion|
|regulation of hormone secretion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|regulation of neuron death|
|regulation of T cell activation|
|response to hypoxia|
|response to acid chemical|
|regulation of chromosome organization|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|response to oxygen levels|
|response to oxidative stress|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|cellular response to drug|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell activation|
|positive regulation of secretion|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|regulation of lymphocyte activation|
|cellular response to lipid|
|response to inorganic substance|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of cell adhesion|
|mitotic cell cycle|
|regulation of cytokine production|
|positive regulation of cell death|
|chromatin organization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of neurogenesis|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|positive regulation of transport|
|response to drug|
|cellular response to oxygen-containing compound|
|chromosome organization|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-3.15|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.07|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.85|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.77|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.71|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.73|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.75|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.76|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.77|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.79|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.8|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.82|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.84|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.97|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.97|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.09|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.1|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.13|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.24|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|2.25|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.27|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.581|
|[[:human genes:c:chd4|CHD4]]|0.548|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.531|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.521|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.511|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.51|
|[[:human genes:r:rps2|RPS2]]|0.509|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.509|
|[[:human genes:p:polr2d|POLR2D]]|0.509|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.508|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.505|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.505|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.504|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.504|
|[[:human genes:c:cbwd3|CBWD3]]|0.497|
|[[:human genes:t:tceb3c|TCEB3C]]|0.495|
|[[:human genes:p:psma6|PSMA6]]|0.492|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.492|
|[[:human genes:r:rrm1|RRM1]]|0.489|
|[[:human genes:s:supt6h|SUPT6H]]|0.488|
|[[:human genes:e:exosc5|EXOSC5]]|0.488|
|[[:human genes:c:cbwd5|CBWD5]]|0.486|
|[[:human genes:r:rps5|RPS5]]|0.483|
|[[:human genes:p:psmd11|PSMD11]]|0.482|
|[[:human genes:p:polr2j3|POLR2J3]]|0.481|
|[[:human genes:t:taf1|TAF1]]|0.48|
|[[:human genes:p:psmc6|PSMC6]]|0.48|
|[[:human genes:p:psmb1|PSMB1]]|0.477|
|[[:human genes:v:vps54|VPS54]]|0.477|
|[[:human genes:u:upf1|UPF1]]|0.474|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.472|
|[[:human genes:p:psmb2|PSMB2]]|0.471|
|[[:human genes:p:psma7|PSMA7]]|0.467|
|[[:human genes:c:cbwd6|CBWD6]]|0.465|
|[[:human genes:k:kctd17|KCTD17]]|0.465|
|[[:human genes:a:aamp|AAMP]]|0.463|
|[[:human genes:p:psmc1|PSMC1]]|0.462|
|[[:human genes:p:prim1|PRIM1]]|0.457|
|[[:human genes:c:copg1|COPG1]]|0.457|
|[[:human genes:b:brd2|BRD2]]|0.453|
|[[:human genes:c:copb2|COPB2]]|0.453|
|[[:human genes:n:nop16|NOP16]]|0.453|
|[[:human genes:t:top1mt|TOP1MT]]|0.451|
|[[:human genes:c:cactin|CACTIN]]|0.448|
|[[:human genes:r:rrp15|RRP15]]|0.448|
|[[:human genes:n:npipb5|NPIPB5]]|0.448|
|[[:human genes:t:tspy1|TSPY1]]|0.448|
|[[:human genes:i:igfn1|IGFN1]]|0.446|
|[[:human genes:r:rps12|RPS12]]|0.445|
|[[:human genes:s:supt5h|SUPT5H]]|0.444|
|[[:human genes:s:sf3a1|SF3A1]]|0.443|
|[[:human genes:p:psmd1|PSMD1]]|0.442|
|[[:human genes:s:syt9|SYT9]]|0.441|
|[[:human genes:f:fam25b|FAM25B]]|0.441|
|[[:human genes:k:kif3c|KIF3C]]|0.44|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.439|
|[[:human genes:z:znf106|ZNF106]]|0.439|
|[[:human genes:c:ccna2|CCNA2]]|0.439|
|[[:human genes:n:npipb8|NPIPB8]]|0.437|
|[[:human genes:r:rps7|RPS7]]|0.436|
|[[:human genes:l:lad1|LAD1]]|0.436|
|[[:human genes:s:stil|STIL]]|0.435|
|[[:human genes:t:twistnb|TWISTNB]]|0.435|
|[[:human genes:o:ogfr|OGFR]]|0.435|
|[[:human genes:p:pola1|POLA1]]|0.434|
|[[:human genes:r:rpl35|RPL35]]|0.433|
|[[:human genes:p:pola2|POLA2]]|0.431|
|[[:human genes:a:ankle2|ANKLE2]]|0.43|
|[[:human genes:d:ddx3x|DDX3X]]|0.429|
|[[:human genes:p:psmc2|PSMC2]]|0.429|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.429|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.427|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.427|
|[[:human genes:n:nbpf10|NBPF10]]|0.427|
|[[:human genes:c:col2a1|COL2A1]]|0.426|
|[[:human genes:a:arcn1|ARCN1]]|0.426|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.424|
|[[:human genes:p:pwp2|PWP2]]|0.424|
|[[:human genes:r:rps11|RPS11]]|0.424|
|[[:human genes:o:orc1|ORC1]]|0.423|
|[[:human genes:r:rps28|RPS28]]|0.423|
|[[:human genes:p:ppan|PPAN]]|0.422|
|[[:human genes:t:tfip11|TFIP11]]|0.422|
|[[:human genes:m:med15|MED15]]|0.421|
|[[:human genes:v:vasn|VASN]]|0.421|
|[[:human genes:c:cdc45|CDC45]]|0.421|
|[[:human genes:n:nup98|NUP98]]|0.418|
|[[:human genes:m:med14|MED14]]|0.418|
|[[:human genes:n:nol10|NOL10]]|0.418|
|[[:human genes:r:rad21|RAD21]]|0.417|
|[[:human genes:r:rpl30|RPL30]]|0.416|
|[[:human genes:d:ddtl|DDTL]]|0.416|
|[[:human genes:h:hap1|HAP1]]|0.416|
|[[:human genes:r:rbbp5|RBBP5]]|0.416|
|[[:human genes:c:cep192|CEP192]]|0.415|
|[[:human genes:n:narfl|NARFL]]|0.413|
|[[:human genes:c:cdc6|CDC6]]|0.412|
|[[:human genes:s:smg1|SMG1]]|0.412|
|[[:human genes:b:bysl|BYSL]]|0.411|
|[[:human genes:m:myo1h|MYO1H]]|0.41|
|[[:human genes:a:aqr|AQR]]|0.41|
|[[:human genes:a:aatf|AATF]]|0.41|
|[[:human genes:a:atxn1|ATXN1]]|0.41|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.408|
|[[:human genes:t:trappc11|TRAPPC11]]|0.408|
|[[:human genes:w:wapal|WAPAL]]|0.408|
|[[:human genes:m:med29|MED29]]|0.408|
|[[:human genes:p:pbxip1|PBXIP1]]|0.407|
|[[:human genes:p:paf1|PAF1]]|0.405|
|[[:human genes:m:mrs2|MRS2]]|0.405|
|[[:human genes:f:fbxo5|FBXO5]]|0.405|
|[[:human genes:u:utp3|UTP3]]|0.405|
|[[:human genes:c:cope|COPE]]|0.404|
|[[:human genes:p:pi4kb|PI4KB]]|0.403|
|[[:human genes:v:vps52|VPS52]]|0.403|
|[[:human genes:e:ep300|EP300]]|0.403|
|[[:human genes:r:rps9|RPS9]]|0.402|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.402|
|[[:human genes:c:ccdc94|CCDC94]]|0.402|
|[[:human genes:s:slc4a1|SLC4A1]]|0.401|
|[[:human genes:s:ssrp1|SSRP1]]|0.401|
|[[:human genes:d:ddt|DDT]]|0.401|
|[[:human genes:r:riok2|RIOK2]]|0.401|
|[[:human genes:r:rpl9|RPL9]]|0.4|
|[[:human genes:n:nol9|NOL9]]|0.4|
|[[:human genes:m:myt1l|MYT1L]]|0.4|
|[[:human genes:c:copz1|COPZ1]]|0.4|
|[[:human genes:s:slc23a3|SLC23A3]]|0.4|
|[[:human genes:r:rnf121|RNF121]]|0.4|
|[[:human genes:c:copa|COPA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 37/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|23/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 486
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYB Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>