======= MYBL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYBL2
  * **<color #00a2e8>Official Name</color>**: MYB proto-oncogene like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4605|4605]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10244|P10244]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYBL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYBL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601415|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. {ECO:0000269|PubMed:10770937}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cmyb C|
|Myb DNA-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Myb complex|
|mitotic spindle assembly|
|positive regulation of neuron apoptotic process|
|mitotic spindle organization|
|positive regulation of neuron death|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic nuclear division|
|spindle organization|
|regulation of neuron apoptotic process|
|nuclear division|
|regulation of neuron death|
|organelle fission|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|microtubule cytoskeleton organization|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|mitotic cell cycle process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|microtubule-based process|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|positive regulation of cell death|
|organelle assembly|
|cell cycle process|
|cellular response to cytokine stimulus|
|response to cytokine|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cell cycle|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.58|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.06|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.05|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.97|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.96|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.91|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.86|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.84|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.77|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.77|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.74|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.72|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.74|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.77|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.78|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.8|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.83|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.91|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ckap5|CKAP5]]|0.416|
|[[:human genes:c:cenpp|CENPP]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 97/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|10/28|
|bone|1/26|
|breast|7/33|
|central nervous system|4/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|0/21|
|liver|0/20|
|lung|10/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1636
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYBL2 Expression in NALM6 Cells: 8.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>