======= MYBPC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYBPC3
  * **<color #00a2e8>Official Name</color>**: myosin binding protein C3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4607|4607]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14896|Q14896]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYBPC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYBPC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600958|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|C zone|
|regulation of muscle filament sliding|
|striated muscle myosin thick filament|
|cardiac myofibril|
|myosin heavy chain binding|
|skeletal muscle myosin thick filament assembly|
|striated muscle myosin thick filament assembly|
|myosin filament assembly|
|A band|
|myosin filament organization|
|skeletal muscle thin filament assembly|
|titin binding|
|skeletal myofibril assembly|
|cardiac muscle fiber development|
|striated muscle thin filament|
|muscle alpha-actinin binding|
|ATPase activator activity|
|myosin binding|
|cardiac myofibril assembly|
|M band|
|actin-myosin filament sliding|
|muscle filament sliding|
|regulation of actin filament-based movement|
|structural constituent of muscle|
|sarcomere organization|
|ventricular cardiac muscle tissue morphogenesis|
|sarcomere|
|positive regulation of ATPase activity|
|ventricular cardiac muscle tissue development|
|muscle fiber development|
|cardiac muscle cell development|
|cardiac cell development|
|myofibril assembly|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|cardiac muscle contraction|
|muscle tissue morphogenesis|
|regulation of ATPase activity|
|heart contraction|
|muscle organ morphogenesis|
|cardiac muscle cell differentiation|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|heart process|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|cardiocyte differentiation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|Z disc|
|striated muscle cell development|
|muscle cell development|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cardiac chamber development|
|striated muscle cell differentiation|
|actin filament binding|
|regulation of muscle system process|
|actin filament organization|
|muscle cell differentiation|
|heart morphogenesis|
|muscle contraction|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|regulation of intracellular transport|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|heart development|
|tissue morphogenesis|
|actin filament-based process|
|regulation of system process|
|organelle assembly|
|positive regulation of hydrolase activity|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component movement|
|identical protein binding|
|cytoskeleton organization|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|cell development|
|tissue development|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.43|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.4|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.01|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.85|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.84|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.71|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11935
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYBPC3 Expression in NALM6 Cells: -0.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>