======= MYF5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYF5
  * **<color #00a2e8>Official Name</color>**: myogenic factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4617|4617]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13349|P13349]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYF5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYF5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
|Basic|
|Myf5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of skeletal muscle fiber development|
|regulation of skeletal muscle fiber development|
|muscle cell fate commitment|
|positive regulation of myoblast fusion|
|cartilage condensation|
|cell aggregation|
|regulation of myoblast fusion|
|positive regulation of myoblast differentiation|
|positive regulation of skeletal muscle tissue development|
|positive regulation of syncytium formation by plasma membrane fusion|
|regulation of syncytium formation by plasma membrane fusion|
|positive regulation of myotube differentiation|
|regulation of skeletal muscle tissue development|
|skeletal muscle cell differentiation|
|E-box binding|
|regulation of myoblast differentiation|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|somitogenesis|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|RNA polymerase II transcription factor complex|
|muscle tissue morphogenesis|
|somite development|
|positive regulation of muscle cell differentiation|
|muscle organ morphogenesis|
|embryonic skeletal system morphogenesis|
|segmentation|
|regulation of striated muscle cell differentiation|
|regulation of cell-matrix adhesion|
|skeletal muscle tissue development|
|embryonic skeletal system development|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of muscle cell differentiation|
|cartilage development|
|regulation of cell-substrate adhesion|
|anterior/posterior pattern specification|
|connective tissue development|
|skeletal system morphogenesis|
|muscle cell differentiation|
|cell fate commitment|
|ossification|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|camera-type eye development|
|regionalization|
|extracellular matrix organization|
|eye development|
|visual system development|
|sensory system development|
|extracellular structure organization|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|protein heterodimerization activity|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of cell development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of cell adhesion|
|anatomical structure formation involved in morphogenesis|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of developmental process|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.74|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6079
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYF5 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>