======= MYH10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYH10
  * **<color #00a2e8>Official Name</color>**: myosin heavy chain 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4628|4628]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35580|P35580]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYH10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYH10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160776|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin N|
|Myosin head|
|Myosin tail 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fourth ventricle development|
|myosin II filament|
|third ventricle development|
|myosin II complex|
|modification of postsynaptic actin cytoskeleton|
|modification of postsynaptic structure|
|substrate-dependent cell migration, cell extension|
|ventricular cardiac muscle cell development|
|lateral ventricle development|
|postsynaptic actin cytoskeleton organization|
|plasma membrane repair|
|actin-dependent ATPase activity|
|actomyosin|
|postsynaptic cytoskeleton organization|
|modification of synaptic structure|
|adult heart development|
|ventricular cardiac muscle cell differentiation|
|microfilament motor activity|
|RNA stem-loop binding|
|nuclear migration|
|cardiac myofibril assembly|
|mRNA 5-UTR binding|
|cerebellar Purkinje cell layer development|
|ventricular system development|
|nucleus localization|
|substrate-dependent cell migration|
|myosin complex|
|ADP binding|
|polysome|
|coronary vasculature development|
|cerebellar cortex development|
|aorta development|
|brush border|
|neuromuscular process controlling balance|
|cleavage furrow|
|cardiac muscle cell development|
|cardiac cell development|
|myofibril assembly|
|mitotic cytokinesis|
|stress fiber|
|neuromuscular junction|
|artery development|
|postsynapse organization|
|cardiac muscle cell differentiation|
|plasma membrane organization|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|cerebellum development|
|cellular component assembly involved in morphogenesis|
|neuromuscular process|
|cardiac septum development|
|actin filament-based movement|
|metencephalon development|
|actomyosin structure organization|
|cardiocyte differentiation|
|neuron migration|
|spindle|
|growth cone|
|striated muscle cell development|
|cell cortex|
|retina development in camera-type eye|
|muscle cell development|
|dendritic spine|
|hindbrain development|
|regulation of cell shape|
|midbody|
|cardiac muscle tissue development|
|cardiac chamber development|
|lamellipodium|
|striated muscle cell differentiation|
|calmodulin binding|
|actin filament binding|
|ATPase activity|
|muscle cell differentiation|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|actin binding|
|synapse organization|
|positive regulation of protein secretion|
|striated muscle tissue development|
|positive regulation of peptide secretion|
|muscle tissue development|
|camera-type eye development|
|glutamatergic synapse|
|eye development|
|visual system development|
|establishment of organelle localization|
|sensory system development|
|axonogenesis|
|neuronal cell body|
|in utero embryonic development|
|forebrain development|
|positive regulation of secretion by cell|
|axon development|
|endomembrane system organization|
|positive regulation of protein transport|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|plasma membrane bounded cell projection assembly|
|supramolecular fiber organization|
|cell projection assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|muscle structure development|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell division|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|vasculature development|
|cell part morphogenesis|
|cardiovascular system development|
|heart development|
|sensory organ development|
|chemotaxis|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|response to wounding|
|organelle localization|
|mitotic cell cycle process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|neuron projection development|
|mitotic cell cycle|
|regulation of protein transport|
|cell morphogenesis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|organelle assembly|
|head development|
|exocytosis|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|membrane organization|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|cell migration|
|embryo development|
|central nervous system development|
|positive regulation of transport|
|cell cycle process|
|secretion by cell|
|neuron differentiation|
|regulation of protein localization|
|export from cell|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|cell cycle|
|nervous system process|
|ATP binding|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|tissue development|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-2.13|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.87|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.86|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5403
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYH10 Expression in NALM6 Cells: 7.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>