======= MYH7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYH7
  * **<color #00a2e8>Official Name</color>**: myosin heavy chain 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4625|4625]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12883|P12883]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYH7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYH7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160760|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin N|
|Myosin tail 1|
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of slow-twitch skeletal muscle fiber contraction|
|regulation of the force of skeletal muscle contraction|
|regulation of skeletal muscle contraction by chemo-mechanical energy conversion|
|regulation of twitch skeletal muscle contraction|
|transition between fast and slow fiber|
|actin-dependent ATPase activity|
|regulation of skeletal muscle contraction|
|muscle hypertrophy in response to stress|
|cardiac muscle hypertrophy in response to stress|
|cardiac muscle adaptation|
|adult heart development|
|muscle myosin complex|
|regulation of skeletal muscle adaptation|
|myosin filament|
|microfilament motor activity|
|regulation of the force of heart contraction|
|striated muscle adaptation|
|myofibril|
|cardiac muscle hypertrophy|
|skeletal muscle contraction|
|striated muscle hypertrophy|
|muscle hypertrophy|
|muscle adaptation|
|myosin complex|
|muscle filament sliding|
|actin-myosin filament sliding|
|musculoskeletal movement|
|multicellular organismal movement|
|ventricular cardiac muscle tissue morphogenesis|
|sarcomere|
|ventricular cardiac muscle tissue development|
|cardiac muscle tissue morphogenesis|
|stress fiber|
|cardiac ventricle morphogenesis|
|cardiac muscle contraction|
|muscle tissue morphogenesis|
|regulation of muscle adaptation|
|muscle organ morphogenesis|
|heart contraction|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|regulation of heart rate|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|Z disc|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cardiac chamber development|
|calmodulin binding|
|actin filament binding|
|ATP metabolic process|
|regulation of muscle system process|
|ATPase activity|
|regulation of heart contraction|
|heart morphogenesis|
|muscle contraction|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|blood circulation|
|circulatory system process|
|muscle structure development|
|heart development|
|tissue morphogenesis|
|actin filament-based process|
|regulation of system process|
|circulatory system development|
|animal organ morphogenesis|
|ATP binding|
|movement of cell or subcellular component|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.72|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.76|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8119
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYH7 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>