======= MYO18A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO18A
  * **<color #00a2e8>Official Name</color>**: myosin XVIIIA
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=399687|399687]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92614|Q92614]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO18A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO18A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610067|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin head|
|Myosin tail 1|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of opsonization|
|asymmetric Golgi ribbon formation|
|regulation of opsonization|
|Golgi ribbon formation|
|actomyosin|
|establishment of epithelial cell polarity|
|myosin complex|
|ADP binding|
|regulation of macrophage activation|
|positive regulation of phagocytosis|
|endoplasmic reticulum-Golgi intermediate compartment|
|Golgi vesicle budding|
|regulation of phagocytosis|
|vesicle budding from membrane|
|actomyosin structure organization|
|establishment of cell polarity|
|Golgi organization|
|trans-Golgi network|
|establishment or maintenance of cell polarity|
|actin filament binding|
|positive regulation of immune effector process|
|ATPase activity|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|vesicle organization|
|Golgi vesicle transport|
|positive regulation of secretion by cell|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|regulation of vesicle-mediated transport|
|actin filament-based process|
|regulation of leukocyte activation|
|cell surface|
|Golgi membrane|
|regulation of cell activation|
|regulation of protein transport|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cell migration|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of protein localization|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|positive regulation of immune system process|
|locomotion|
|RNA binding|
|DNA binding|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of immune system process|
|regulation of cell death|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.78|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.8|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pde4dip|PDE4DIP]]|0.482|
|[[:human genes:p:psmb2|PSMB2]]|0.479|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.476|
|[[:human genes:c:chd4|CHD4]]|0.471|
|[[:human genes:c:c14orf93|C14orf93]]|0.466|
|[[:human genes:a:akirin2|AKIRIN2]]|0.466|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.46|
|[[:human genes:c:copg1|COPG1]]|0.449|
|[[:human genes:c:ccdc94|CCDC94]]|0.447|
|[[:human genes:s:ssh2|SSH2]]|0.443|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.442|
|[[:human genes:c:ccna2|CCNA2]]|0.442|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.441|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.441|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.44|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.44|
|[[:human genes:c:cgb2|CGB2]]|0.439|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.439|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.438|
|[[:human genes:s:slc4a1|SLC4A1]]|0.438|
|[[:human genes:p:psmd3|PSMD3]]|0.437|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.435|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.434|
|[[:human genes:e:exosc9|EXOSC9]]|0.432|
|[[:human genes:s:s1pr4|S1PR4]]|0.431|
|[[:human genes:n:nupl1|NUPL1]]|0.431|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.43|
|[[:human genes:n:napa|NAPA]]|0.429|
|[[:human genes:r:rrn3|RRN3]]|0.427|
|[[:human genes:p:psmb4|PSMB4]]|0.427|
|[[:human genes:p:pola1|POLA1]]|0.425|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.424|
|[[:human genes:e:exosc5|EXOSC5]]|0.423|
|[[:human genes:k:kctd17|KCTD17]]|0.423|
|[[:human genes:t:trim52|TRIM52]]|0.421|
|[[:human genes:r:rbbp5|RBBP5]]|0.421|
|[[:human genes:t:tfip11|TFIP11]]|0.419|
|[[:human genes:p:polr2j3|POLR2J3]]|0.418|
|[[:human genes:r:rpl35|RPL35]]|0.417|
|[[:human genes:h:hmgcr|HMGCR]]|0.417|
|[[:human genes:c:cope|COPE]]|0.416|
|[[:human genes:c:cdh24|CDH24]]|0.416|
|[[:human genes:t:tceb3c|TCEB3C]]|0.416|
|[[:human genes:o:orc1|ORC1]]|0.415|
|[[:human genes:c:copa|COPA]]|0.414|
|[[:human genes:c:chst3|CHST3]]|0.414|
|[[:human genes:p:paf1|PAF1]]|0.413|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.413|
|[[:human genes:a:arcn1|ARCN1]]|0.411|
|[[:human genes:s:supt5h|SUPT5H]]|0.411|
|[[:human genes:m:mt1e|MT1E]]|0.41|
|[[:human genes:r:rpl6|RPL6]]|0.41|
|[[:human genes:z:znf106|ZNF106]]|0.408|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.408|
|[[:human genes:c:chmp2a|CHMP2A]]|0.406|
|[[:human genes:r:rps7|RPS7]]|0.404|
|[[:human genes:p:psmd11|PSMD11]]|0.403|
|[[:human genes:p:pole|POLE]]|0.402|
|[[:human genes:v:vasn|VASN]]|0.401|
|[[:human genes:p:pbxip1|PBXIP1]]|0.401|
|[[:human genes:l:lrr1|LRR1]]|0.4|
|[[:human genes:p:polr1a|POLR1A]]|0.4|
|[[:human genes:e:exosc4|EXOSC4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2201
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO18A Expression in NALM6 Cells: 8.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>