======= MYO7A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO7A
  * **<color #00a2e8>Official Name</color>**: myosin VIIA
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4647|4647]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13402|Q13402]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO7A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO7A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/276903|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. {ECO:0000250, ECO:0000269|PubMed:19643958, ECO:0000269|PubMed:21493626, ECO:0000269|PubMed:21687988, ECO:0000269|PubMed:21709241}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin head|
|MyTH4|
|IQ|
|FERM M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myosin VII complex|
|stereocilium base|
|upper tip-link density|
|equilibrioception|
|post-embryonic animal organ morphogenesis|
|auditory receptor cell stereocilium organization|
|actin-dependent ATPase activity|
|post-embryonic animal morphogenesis|
|phagolysosome assembly|
|auditory receptor cell morphogenesis|
|post-embryonic animal organ development|
|auditory receptor cell development|
|microfilament motor activity|
|pigment granule transport|
|establishment of pigment granule localization|
|pigment granule localization|
|inner ear auditory receptor cell differentiation|
|inner ear receptor cell stereocilium organization|
|spectrin binding|
|stereocilium|
|eye photoreceptor cell development|
|hair cell differentiation|
|ADP binding|
|photoreceptor connecting cilium|
|inner ear receptor cell development|
|phagosome maturation|
|neuroepithelial cell differentiation|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|cellular pigmentation|
|columnar/cuboidal epithelial cell development|
|photoreceptor inner segment|
|neuromuscular process controlling balance|
|inner ear receptor cell differentiation|
|photoreceptor cell differentiation|
|mechanoreceptor differentiation|
|lysosome organization|
|lytic vacuole organization|
|photoreceptor outer segment|
|microvillus|
|post-embryonic development|
|pigmentation|
|columnar/cuboidal epithelial cell differentiation|
|inner ear morphogenesis|
|melanosome|
|protein N-terminus binding|
|neuromuscular process|
|actin filament-based movement|
|ear morphogenesis|
|vacuole organization|
|cell cortex|
|sensory perception of sound|
|eye morphogenesis|
|sensory perception of mechanical stimulus|
|establishment of vesicle localization|
|vesicle localization|
|epithelial cell development|
|inner ear development|
|calmodulin binding|
|actin filament binding|
|ear development|
|visual perception|
|sensory perception of light stimulus|
|protein domain specific binding|
|sensory organ morphogenesis|
|synapse|
|embryonic organ morphogenesis|
|vesicle organization|
|lysosomal membrane|
|epidermal cell differentiation|
|apical plasma membrane|
|phagocytosis|
|eye development|
|visual system development|
|establishment of organelle localization|
|sensory system development|
|epidermis development|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|actin filament-based process|
|organelle localization|
|neuron projection development|
|epithelial cell differentiation|
|cell morphogenesis|
|organelle assembly|
|neuron development|
|cellular component morphogenesis|
|protein homodimerization activity|
|animal organ morphogenesis|
|sensory perception|
|embryo development|
|intracellular protein transport|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|nervous system process|
|ATP binding|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8578
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO7A Expression in NALM6 Cells: 1.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>