======= MYOC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYOC
  * **<color #00a2e8>Official Name</color>**: myocilin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4653|4653]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99972|Q99972]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYOC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYOC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601652|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork. {ECO:0000250|UniProtKB:O70624, ECO:0000269|PubMed:17516541, ECO:0000269|PubMed:17984096, ECO:0000269|PubMed:18855004, ECO:0000269|PubMed:19188438, ECO:0000269|PubMed:19959812, ECO:0000269|PubMed:21656515, ECO:0000269|PubMed:23629661, ECO:0000269|PubMed:23897819}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OLF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|skeletal muscle hypertrophy|
|ERBB2-ERBB3 signaling pathway|
|ERBB3 signaling pathway|
|non-canonical Wnt signaling pathway via JNK cascade|
|non-canonical Wnt signaling pathway via MAPK cascade|
|myosin light chain binding|
|clustering of voltage-gated sodium channels|
|positive regulation of mitochondrial depolarization|
|skeletal muscle adaptation|
|neuronal ion channel clustering|
|positive regulation of membrane depolarization|
|node of Ranvier|
|regulation of mitochondrial depolarization|
|negative regulation of stress fiber assembly|
|negative regulation of Rho protein signal transduction|
|negative regulation of actin filament bundle assembly|
|positive regulation of focal adhesion assembly|
|myelination in peripheral nervous system|
|peripheral nervous system axon ensheathment|
|striated muscle adaptation|
|fibronectin binding|
|Schwann cell development|
|striated muscle hypertrophy|
|positive regulation of adherens junction organization|
|muscle adaptation|
|muscle hypertrophy|
|ERBB2 signaling pathway|
|positive regulation of cell junction assembly|
|Schwann cell differentiation|
|positive regulation of substrate adhesion-dependent cell spreading|
|negative regulation of cell-matrix adhesion|
|neuron maturation|
|frizzled binding|
|regulation of membrane depolarization|
|positive regulation of cell-matrix adhesion|
|positive regulation of stress fiber assembly|
|regulation of substrate adhesion-dependent cell spreading|
|negative regulation of Ras protein signal transduction|
|receptor tyrosine kinase binding|
|negative regulation of small GTPase mediated signal transduction|
|rough endoplasmic reticulum|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|positive regulation of actin filament bundle assembly|
|negative regulation of cell-substrate adhesion|
|regulation of adherens junction organization|
|ERBB signaling pathway|
|regulation of mitochondrial membrane potential|
|peripheral nervous system development|
|mitochondrial intermembrane space|
|regulation of stress fiber assembly|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|regulation of cell junction assembly|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|regulation of cell-matrix adhesion|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of cell-substrate adhesion|
|osteoblast differentiation|
|negative regulation of supramolecular fiber organization|
|non-canonical Wnt signaling pathway|
|anatomical structure maturation|
|negative regulation of cytoskeleton organization|
|regulation of Rho protein signal transduction|
|positive regulation of cell morphogenesis involved in differentiation|
|cell maturation|
|mitochondrial outer membrane|
|positive regulation of protein kinase B signaling|
|glial cell differentiation|
|positive regulation of supramolecular fiber organization|
|cilium|
|bone development|
|regulation of cell-substrate adhesion|
|gliogenesis|
|positive regulation of cytoskeleton organization|
|regulation of protein kinase B signaling|
|developmental maturation|
|regulation of Ras protein signal transduction|
|cytoplasmic vesicle|
|regulation of actin filament organization|
|ossification|
|negative regulation of cell adhesion|
|muscle system process|
|regulation of cell morphogenesis involved in differentiation|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|collagen-containing extracellular matrix|
|negative regulation of organelle organization|
|regulation of actin filament-based process|
|mitochondrial inner membrane|
|positive regulation of cell adhesion|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|regulation of cell morphogenesis|
|skeletal system development|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of locomotion|
|positive regulation of organelle organization|
|neuron projection development|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|ion homeostasis|
|neuron development|
|regulation of cell migration|
|membrane organization|
|regulation of cell motility|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|endoplasmic reticulum|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.92|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.75|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.73|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3315
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYOC Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>