======= MYOD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYOD1
  * **<color #00a2e8>Official Name</color>**: myogenic differentiation 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4654|4654]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15172|P15172]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYOD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYOD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myf5|
|Basic|
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of snRNA transcription by RNA polymerase II|
|regulation of snRNA transcription by RNA polymerase II|
|negative regulation of myoblast proliferation|
|myoblast fate determination|
|skeletal muscle fiber adaptation|
|positive regulation of skeletal muscle tissue regeneration|
|myoblast fate commitment|
|myotube differentiation involved in skeletal muscle regeneration|
|positive regulation of skeletal muscle fiber development|
|regulation of skeletal muscle tissue regeneration|
|regulation of skeletal muscle fiber development|
|skeletal muscle adaptation|
|regulation of myoblast proliferation|
|muscle cell fate commitment|
|positive regulation of myoblast fusion|
|regulation of myoblast fusion|
|positive regulation of myoblast differentiation|
|myoblast fusion|
|skeletal muscle fiber development|
|positive regulation of skeletal muscle tissue development|
|nuclear hormone receptor binding|
|striated muscle adaptation|
|myotube cell development|
|positive regulation of syncytium formation by plasma membrane fusion|
|myofibril|
|regulation of syncytium formation by plasma membrane fusion|
|positive regulation of myotube differentiation|
|muscle adaptation|
|myoblast differentiation|
|skeletal muscle tissue regeneration|
|cell-cell fusion|
|syncytium formation by plasma membrane fusion|
|cellular response to estradiol stimulus|
|syncytium formation|
|cell fate determination|
|histone H3 acetylation|
|promoter-specific chromatin binding|
|regulation of skeletal muscle tissue development|
|E-box binding|
|skeletal muscle cell differentiation|
|regulation of myoblast differentiation|
|positive regulation of wound healing|
|histone H4 acetylation|
|cellular response to glucocorticoid stimulus|
|myotube differentiation|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|muscle fiber development|
|cellular response to corticosteroid stimulus|
|tissue regeneration|
|positive regulation of response to wounding|
|regulation of alternative mRNA splicing, via spliceosome|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|positive regulation of muscle tissue development|
|chromatin DNA binding|
|positive regulation of muscle cell differentiation|
|regulation of mRNA splicing, via spliceosome|
|regulation of striated muscle cell differentiation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|skeletal muscle tissue development|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|regulation of muscle tissue development|
|striated muscle cell development|
|response to estradiol|
|regulation of muscle organ development|
|regulation of RNA splicing|
|regulation of mRNA processing|
|regulation of wound healing|
|protein acetylation|
|response to glucocorticoid|
|muscle cell development|
|cellular response to starvation|
|regulation of muscle cell differentiation|
|regeneration|
|response to corticosteroid|
|regulation of response to wounding|
|positive regulation of developmental growth|
|cellular response to steroid hormone stimulus|
|protein acylation|
|response to starvation|
|striated muscle cell differentiation|
|transcription factor complex|
|cellular response to oxygen levels|
|cellular response to nutrient levels|
|nuclear chromatin|
|cellular response to tumor necrosis factor|
|muscle cell differentiation|
|cell fate commitment|
|positive regulation of growth|
|response to tumor necrosis factor|
|cellular response to extracellular stimulus|
|nuclear body|
|transcription coactivator activity|
|striated muscle tissue development|
|ubiquitin protein ligase binding|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|peptidyl-lysine modification|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to steroid hormone|
|regulation of mRNA metabolic process|
|regulation of developmental growth|
|cellular response to external stimulus|
|histone modification|
|covalent chromatin modification|
|response to oxygen levels|
|developmental growth|
|growth|
|chromatin binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|wound healing|
|protein heterodimerization activity|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|response to wounding|
|cellular response to hormone stimulus|
|regulation of growth|
|negative regulation of cell population proliferation|
|chromatin organization|
|response to lipid|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|response to organic cyclic compound|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein phosphorylation|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|regulation of response to external stimulus|
|response to cytokine|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|phosphorylation|
|positive regulation of developmental process|
|response to endogenous stimulus|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16268
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYOD1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>