======= NARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/ARS2
  * **<color #00a2e8>Official Name</color>**: asparaginyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79731|79731]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96I59|Q96I59]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612803|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). [provided by RefSeq, Mar 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 2|
|tRNA anti|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|asparagine-tRNA ligase activity|
|asparaginyl-tRNA aminoacylation|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|nucleic acid binding|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.75|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.74|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.78|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.78|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.78|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.79|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.8|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.81|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.86|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.89|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.93|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.94|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.94|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.08|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.2|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.25|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.25|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.31|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.41|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.45|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.51|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.52|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.53|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.77|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lars2|LARS2]]|0.763|
|[[:human genes:d:dap3|DAP3]]|0.76|
|[[:human genes:s:selrc1|SELRC1]]|0.756|
|[[:human genes:y:yars2|YARS2]]|0.756|
|[[:human genes:t:tars2|TARS2]]|0.749|
|[[:human genes:r:rars2|RARS2]]|0.742|
|[[:human genes:m:mrps6|MRPS6]]|0.742|
|[[:human genes:q:qrsl1|QRSL1]]|0.736|
|[[:human genes:g:gfm1|GFM1]]|0.731|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.73|
|[[:human genes:e:ears2|EARS2]]|0.728|
|[[:human genes:m:mrpl21|MRPL21]]|0.725|
|[[:human genes:m:mrps21|MRPS21]]|0.723|
|[[:human genes:p:pars2|PARS2]]|0.722|
|[[:human genes:p:pet112|PET112]]|0.71|
|[[:human genes:s:sco2|SCO2]]|0.704|
|[[:human genes:c:coa3|COA3]]|0.695|
|[[:human genes:r:rpusd4|RPUSD4]]|0.689|
|[[:human genes:f:ftsj2|FTSJ2]]|0.688|
|[[:human genes:m:mrps16|MRPS16]]|0.685|
|[[:human genes:d:dars2|DARS2]]|0.685|
|[[:human genes:m:mrps14|MRPS14]]|0.683|
|[[:human genes:a:aars2|AARS2]]|0.68|
|[[:human genes:v:vars2|VARS2]]|0.677|
|[[:human genes:m:mrpl23|MRPL23]]|0.675|
|[[:human genes:r:rbfa|RBFA]]|0.673|
|[[:human genes:p:pet117|PET117]]|0.67|
|[[:human genes:h:hars2|HARS2]]|0.668|
|[[:human genes:m:mrpl45|MRPL45]]|0.665|
|[[:human genes:m:mrps34|MRPS34]]|0.653|
|[[:human genes:f:fastkd5|FASTKD5]]|0.651|
|[[:human genes:m:mars2|MARS2]]|0.646|
|[[:human genes:b:bcs1l|BCS1L]]|0.643|
|[[:human genes:m:mrpl3|MRPL3]]|0.643|
|[[:human genes:w:wbscr16|WBSCR16]]|0.642|
|[[:human genes:t:tefm|TEFM]]|0.642|
|[[:human genes:p:polg2|POLG2]]|0.636|
|[[:human genes:m:mtg2|MTG2]]|0.636|
|[[:human genes:g:gatc|GATC]]|0.635|
|[[:human genes:c:cox11|COX11]]|0.633|
|[[:human genes:n:ndufb11|NDUFB11]]|0.63|
|[[:human genes:c:cox16|COX16]]|0.63|
|[[:human genes:m:mrp63|MRP63]]|0.629|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.629|
|[[:human genes:m:mrpl12|MRPL12]]|0.626|
|[[:human genes:m:mrps5|MRPS5]]|0.626|
|[[:human genes:m:mrpl53|MRPL53]]|0.621|
|[[:human genes:m:mrpl47|MRPL47]]|0.618|
|[[:human genes:c:cars2|CARS2]]|0.616|
|[[:human genes:w:wars2|WARS2]]|0.616|
|[[:human genes:p:polg|POLG]]|0.614|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.61|
|[[:human genes:m:mettl17|METTL17]]|0.608|
|[[:human genes:m:mrps25|MRPS25]]|0.608|
|[[:human genes:r:rpusd3|RPUSD3]]|0.603|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.601|
|[[:human genes:c:c10orf2|C10orf2]]|0.6|
|[[:human genes:m:mrps18a|MRPS18A]]|0.6|
|[[:human genes:t:tfb1m|TFB1M]]|0.598|
|[[:human genes:c:cox15|COX15]]|0.598|
|[[:human genes:m:mrps26|MRPS26]]|0.597|
|[[:human genes:g:gfm2|GFM2]]|0.593|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.593|
|[[:human genes:c:coa6|COA6]]|0.587|
|[[:human genes:m:mrpl20|MRPL20]]|0.583|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.582|
|[[:human genes:m:mrps10|MRPS10]]|0.578|
|[[:human genes:m:mrpl42|MRPL42]]|0.576|
|[[:human genes:n:ndufa1|NDUFA1]]|0.576|
|[[:human genes:m:mterfd1|MTERFD1]]|0.573|
|[[:human genes:m:mrps22|MRPS22]]|0.572|
|[[:human genes:p:pnpt1|PNPT1]]|0.571|
|[[:human genes:p:polrmt|POLRMT]]|0.571|
|[[:human genes:c:cox7b|COX7B]]|0.569|
|[[:human genes:m:mterfd2|MTERFD2]]|0.568|
|[[:human genes:m:mrpl43|MRPL43]]|0.564|
|[[:human genes:m:mrps12|MRPS12]]|0.562|
|[[:human genes:m:mrpl4|MRPL4]]|0.562|
|[[:human genes:m:mtg1|MTG1]]|0.562|
|[[:human genes:n:ndufa3|NDUFA3]]|0.561|
|[[:human genes:c:cox20|COX20]]|0.561|
|[[:human genes:m:malsu1|MALSU1]]|0.56|
|[[:human genes:d:ddx28|DDX28]]|0.559|
|[[:human genes:m:mrps27|MRPS27]]|0.559|
|[[:human genes:f:fars2|FARS2]]|0.555|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.554|
|[[:human genes:n:ndufc2|NDUFC2]]|0.553|
|[[:human genes:p:pgm3|PGM3]]|0.549|
|[[:human genes:m:mrps35|MRPS35]]|0.548|
|[[:human genes:m:mrps9|MRPS9]]|0.546|
|[[:human genes:m:mipep|MIPEP]]|0.546|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.546|
|[[:human genes:s:ssbp1|SSBP1]]|0.545|
|[[:human genes:m:mtif2|MTIF2]]|0.543|
|[[:human genes:n:ndufs2|NDUFS2]]|0.543|
|[[:human genes:m:mrps24|MRPS24]]|0.541|
|[[:human genes:a:atp5sl|ATP5SL]]|0.541|
|[[:human genes:m:mrps2|MRPS2]]|0.538|
|[[:human genes:t:tmem242|TMEM242]]|0.536|
|[[:human genes:a:acad9|ACAD9]]|0.536|
|[[:human genes:c:clpp|CLPP]]|0.535|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.534|
|[[:human genes:t:tufm|TUFM]]|0.532|
|[[:human genes:t:tfam|TFAM]]|0.531|
|[[:human genes:n:ndufb6|NDUFB6]]|0.528|
|[[:human genes:t:trub2|TRUB2]]|0.528|
|[[:human genes:a:atp5c1|ATP5C1]]|0.527|
|[[:human genes:n:ndufa2|NDUFA2]]|0.527|
|[[:human genes:c:c12orf65|C12orf65]]|0.527|
|[[:human genes:m:mrps23|MRPS23]]|0.524|
|[[:human genes:m:mrpl39|MRPL39]]|0.524|
|[[:human genes:d:dnlz|DNLZ]]|0.523|
|[[:human genes:m:mrpl35|MRPL35]]|0.523|
|[[:human genes:s:sars2|SARS2]]|0.519|
|[[:human genes:m:mrpl18|MRPL18]]|0.519|
|[[:human genes:n:nsun4|NSUN4]]|0.518|
|[[:human genes:s:slc25a26|SLC25A26]]|0.517|
|[[:human genes:t:tomm20|TOMM20]]|0.517|
|[[:human genes:m:mrpl44|MRPL44]]|0.517|
|[[:human genes:e:eral1|ERAL1]]|0.516|
|[[:human genes:n:ndufb9|NDUFB9]]|0.515|
|[[:human genes:m:mrpl2|MRPL2]]|0.515|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.515|
|[[:human genes:m:mrps7|MRPS7]]|0.514|
|[[:human genes:m:mrps33|MRPS33]]|0.511|
|[[:human genes:d:dhrsx|DHRSX]]|0.509|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.509|
|[[:human genes:g:grsf1|GRSF1]]|0.508|
|[[:human genes:m:mrpl33|MRPL33]]|0.506|
|[[:human genes:m:mrpl49|MRPL49]]|0.505|
|[[:human genes:m:mrpl15|MRPL15]]|0.505|
|[[:human genes:c:coq7|COQ7]]|0.505|
|[[:human genes:h:higd2a|HIGD2A]]|0.502|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.502|
|[[:human genes:a:aifm1|AIFM1]]|0.502|
|[[:human genes:l:lrpprc|LRPPRC]]|0.501|
|[[:human genes:p:pmvk|PMVK]]|0.5|
|[[:human genes:m:mrpl11|MRPL11]]|0.498|
|[[:human genes:p:ptcd3|PTCD3]]|0.497|
|[[:human genes:c:cox17|COX17]]|0.497|
|[[:human genes:n:ndufb5|NDUFB5]]|0.496|
|[[:human genes:c:chchd1|CHCHD1]]|0.495|
|[[:human genes:m:mrps28|MRPS28]]|0.491|
|[[:human genes:n:ndufa11|NDUFA11]]|0.491|
|[[:human genes:f:fastkd2|FASTKD2]]|0.49|
|[[:human genes:m:mto1|MTO1]]|0.49|
|[[:human genes:m:mrps18b|MRPS18B]]|0.488|
|[[:human genes:i:iba57|IBA57]]|0.488|
|[[:human genes:c:cox19|COX19]]|0.484|
|[[:human genes:n:ndufs5|NDUFS5]]|0.484|
|[[:human genes:m:mrpl51|MRPL51]]|0.484|
|[[:human genes:m:mrpl17|MRPL17]]|0.483|
|[[:human genes:f:fh|FH]]|0.483|
|[[:human genes:n:ndufv1|NDUFV1]]|0.482|
|[[:human genes:c:coq2|COQ2]]|0.482|
|[[:human genes:m:mrpl37|MRPL37]]|0.48|
|[[:human genes:m:mtpap|MTPAP]]|0.48|
|[[:human genes:m:mrps11|MRPS11]]|0.48|
|[[:human genes:m:mtrf1|MTRF1]]|0.477|
|[[:human genes:n:nubpl|NUBPL]]|0.476|
|[[:human genes:m:mrpl28|MRPL28]]|0.475|
|[[:human genes:s:slc25a3|SLC25A3]]|0.475|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.474|
|[[:human genes:m:mrpl13|MRPL13]]|0.473|
|[[:human genes:t:trmt10c|TRMT10C]]|0.472|
|[[:human genes:n:ndufa8|NDUFA8]]|0.47|
|[[:human genes:a:alas1|ALAS1]]|0.47|
|[[:human genes:p:pdss1|PDSS1]]|0.47|
|[[:human genes:m:mrps17|MRPS17]]|0.469|
|[[:human genes:l:lsm10|LSM10]]|0.466|
|[[:human genes:m:mrpl52|MRPL52]]|0.466|
|[[:human genes:m:mrpl22|MRPL22]]|0.465|
|[[:human genes:m:mrpl1|MRPL1]]|0.465|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.462|
|[[:human genes:m:mettl1|METTL1]]|0.462|
|[[:human genes:m:mrpl38|MRPL38]]|0.461|
|[[:human genes:i:ict1|ICT1]]|0.461|
|[[:human genes:t:tfb2m|TFB2M]]|0.46|
|[[:human genes:n:ndufs1|NDUFS1]]|0.457|
|[[:human genes:m:mcat|MCAT]]|0.457|
|[[:human genes:c:c1qbp|C1QBP]]|0.456|
|[[:human genes:a:atp5a1|ATP5A1]]|0.456|
|[[:human genes:t:tmem261|TMEM261]]|0.454|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.454|
|[[:human genes:e:elac2|ELAC2]]|0.454|
|[[:human genes:n:ndufc1|NDUFC1]]|0.454|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.453|
|[[:human genes:n:ndufs7|NDUFS7]]|0.452|
|[[:human genes:p:ppcdc|PPCDC]]|0.452|
|[[:human genes:a:atp5d|ATP5D]]|0.451|
|[[:human genes:m:mrpl36|MRPL36]]|0.451|
|[[:human genes:m:mrpl55|MRPL55]]|0.451|
|[[:human genes:u:uqcr10|UQCR10]]|0.451|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.448|
|[[:human genes:t:tomm7|TOMM7]]|0.447|
|[[:human genes:c:coq3|COQ3]]|0.446|
|[[:human genes:d:dhx30|DHX30]]|0.446|
|[[:human genes:e:ecsit|ECSIT]]|0.445|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.445|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.443|
|[[:human genes:n:ndufb3|NDUFB3]]|0.443|
|[[:human genes:m:mrpl46|MRPL46]]|0.44|
|[[:human genes:c:coq6|COQ6]]|0.439|
|[[:human genes:c:cox6c|COX6C]]|0.437|
|[[:human genes:p:pet100|PET100]]|0.437|
|[[:human genes:c:coq4|COQ4]]|0.436|
|[[:human genes:s:sco1|SCO1]]|0.434|
|[[:human genes:t:tomm22|TOMM22]]|0.433|
|[[:human genes:c:cox6b1|COX6B1]]|0.433|
|[[:human genes:c:coq5|COQ5]]|0.433|
|[[:human genes:f:fastkd1|FASTKD1]]|0.432|
|[[:human genes:a:adat2|ADAT2]]|0.429|
|[[:human genes:a:atp5b|ATP5B]]|0.428|
|[[:human genes:o:opa1|OPA1]]|0.428|
|[[:human genes:t:trmt61a|TRMT61A]]|0.428|
|[[:human genes:s:slc25a51|SLC25A51]]|0.428|
|[[:human genes:s:slc7a1|SLC7A1]]|0.427|
|[[:human genes:n:ndufa10|NDUFA10]]|0.426|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.423|
|[[:human genes:p:ptcd1|PTCD1]]|0.421|
|[[:human genes:r:rpia|RPIA]]|0.418|
|[[:human genes:m:mrpl24|MRPL24]]|0.418|
|[[:human genes:a:alg6|ALG6]]|0.418|
|[[:human genes:s:slc25a52|SLC25A52]]|0.416|
|[[:human genes:m:mrpl34|MRPL34]]|0.415|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.414|
|[[:human genes:m:mrpl32|MRPL32]]|0.414|
|[[:human genes:m:mrpl27|MRPL27]]|0.412|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.411|
|[[:human genes:m:mtif3|MTIF3]]|0.41|
|[[:human genes:m:mrpl41|MRPL41]]|0.409|
|[[:human genes:p:pdss2|PDSS2]]|0.409|
|[[:human genes:p:ptrhd1|PTRHD1]]|0.408|
|[[:human genes:p:pitrm1|PITRM1]]|0.406|
|[[:human genes:a:alg8|ALG8]]|0.406|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.404|
|[[:human genes:c:c17orf89|C17orf89]]|0.404|
|[[:human genes:s:ssb|SSB]]|0.403|
|[[:human genes:p:prepl|PREPL]]|0.403|
|[[:human genes:f:fech|FECH]]|0.403|
|[[:human genes:n:ndufb10|NDUFB10]]|0.402|
|[[:human genes:s:slc31a1|SLC31A1]]|0.402|
|[[:human genes:n:ndufb7|NDUFB7]]|0.402|
|[[:human genes:t:tomm6|TOMM6]]|0.402|
|[[:human genes:c:cox5a|COX5A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 391
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NARS2 Expression in NALM6 Cells: 4.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>