======= NASP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/ASP
  * **<color #00a2e8>Official Name</color>**: nuclear autoantigenic sperm protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4678|4678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49321|P49321]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NASP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NASP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603185|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SHNi-TPR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA replication-dependent nucleosome assembly|
|DNA replication-dependent nucleosome organization|
|CENP-A containing nucleosome assembly|
|CENP-A containing chromatin organization|
|chromatin remodeling at centromere|
|response to testosterone|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone exchange|
|ATP-dependent chromatin remodeling|
|blastocyst development|
|nucleosome assembly|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|histone binding|
|chromatin assembly|
|male gonad development|
|development of primary male sexual characteristics|
|chromatin assembly or disassembly|
|nucleosome organization|
|male sex differentiation|
|chromatin remodeling|
|DNA packaging|
|response to ketone|
|protein-DNA complex assembly|
|gonad development|
|DNA replication|
|development of primary sexual characteristics|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|sex differentiation|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|DNA conformation change|
|in utero embryonic development|
|reproductive structure development|
|reproductive system development|
|cell population proliferation|
|protein-containing complex|
|mitotic cell cycle process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|mitotic cell cycle|
|chromatin organization|
|cellular protein-containing complex assembly|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|embryo development|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.73|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.76|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4292
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NASP Expression in NALM6 Cells: 9.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>