======= NCAPG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCAPG2
  * **<color #00a2e8>Official Name</color>**: non-SMC condensin II complex subunit G2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54892|54892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86XI2|Q86XI2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCAPG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCAPG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608532|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. {ECO:0000269|PubMed:14532007}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Condensin2nSMC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|molecular function regulator|
|condensin complex|
|negative regulation of erythrocyte differentiation|
|inner cell mass cell proliferation|
|blastocyst growth|
|bHLH transcription factor binding|
|positive regulation of signaling receptor activity|
|chromosome condensation|
|regulation of erythrocyte differentiation|
|positive regulation of protein tyrosine kinase activity|
|methylated histone binding|
|negative regulation of myeloid cell differentiation|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|regulation of protein tyrosine kinase activity|
|blastocyst development|
|myeloid cell homeostasis|
|negative regulation of hemopoiesis|
|regulation of signaling receptor activity|
|DNA packaging|
|positive regulation of peptidyl-tyrosine phosphorylation|
|homeostasis of number of cells|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|regulation of peptidyl-tyrosine phosphorylation|
|DNA conformation change|
|in utero embryonic development|
|developmental growth|
|growth|
|nuclear speck|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|transcription by RNA polymerase II|
|cell division|
|positive regulation of protein kinase activity|
|cell population proliferation|
|hemopoiesis|
|positive regulation of kinase activity|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|positive regulation of transferase activity|
|negative regulation of cell differentiation|
|regulation of protein kinase activity|
|regulation of kinase activity|
|negative regulation of developmental process|
|regulation of transferase activity|
|embryo development|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.29|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-2.18|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.12|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.88|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.86|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.76|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.75|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.75|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.74|
|[[:results:exp539|42°C R08 exp539]]|1.75|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 441/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|19/28|
|bone|15/25|
|breast|19/33|
|central nervous system|35/56|
|cervix|0/4|
|colorectal|9/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|10/15|
|kidney|17/21|
|liver|11/20|
|lung|54/75|
|lymphocyte|4/14|
|ovary|14/26|
|pancreas|13/24|
|peripheral nervous system|6/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|20/24|
|soft tissue|3/7|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|12/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2662
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCAPG2 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>