======= NDC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDC1
  * **<color #00a2e8>Official Name</color>**: NDC1 transmembrane nucleoporin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55706|55706]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BTX1|Q9BTX1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610115|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ndc1 Nup|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore transmembrane ring|
|nuclear pore localization|
|nuclear pore distribution|
|nuclear pore complex assembly|
|nuclear pore organization|
|pore complex assembly|
|cellular protein-containing complex localization|
|structural constituent of nuclear pore|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|synapsis|
|intracellular transport of virus|
|host cell|
|transport of virus|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|protein sumoylation|
|multi-organism localization|
|multi-organism transport|
|nuclear pore|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|localization within membrane|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|meiotic chromosome segregation|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|meiosis I|
|meiosis I cell cycle process|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|nucleus organization|
|protein export from nucleus|
|meiotic nuclear division|
|mRNA transport|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|meiotic cell cycle process|
|nuclear envelope|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|actin cytoskeleton|
|nuclear chromosome segregation|
|meiotic cell cycle|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|chromosome segregation|
|nuclear division|
|organelle fission|
|peptidyl-lysine modification|
|regulation of small molecule metabolic process|
|spermatogenesis|
|male gamete generation|
|gamete generation|
|viral process|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|multi-organism reproductive process|
|intracellular protein transport|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.71|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.72|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.73|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.86|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.89|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.91|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.97|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.11|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.12|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2.37|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:akirin2|AKIRIN2]]|0.527|
|[[:human genes:s:snrpa1|SNRPA1]]|0.517|
|[[:human genes:a:aaas|AAAS]]|0.51|
|[[:human genes:a:ahctf1|AHCTF1]]|0.506|
|[[:human genes:a:atp13a1|ATP13A1]]|0.484|
|[[:human genes:c:c14orf93|C14orf93]]|0.475|
|[[:human genes:n:nup54|NUP54]]|0.463|
|[[:human genes:t:tfip11|TFIP11]]|0.453|
|[[:human genes:n:nup85|NUP85]]|0.453|
|[[:human genes:c:cdca3|CDCA3]]|0.447|
|[[:human genes:c:ckap5|CKAP5]]|0.444|
|[[:human genes:n:nup188|NUP188]]|0.441|
|[[:human genes:v:vasn|VASN]]|0.439|
|[[:human genes:p:psmd1|PSMD1]]|0.436|
|[[:human genes:c:ccdc94|CCDC94]]|0.433|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.432|
|[[:human genes:s:s1pr4|S1PR4]]|0.432|
|[[:human genes:s:smg7|SMG7]]|0.431|
|[[:human genes:e:eif4a3|EIF4A3]]|0.431|
|[[:human genes:p:psmd6|PSMD6]]|0.43|
|[[:human genes:c:cwc22|CWC22]]|0.429|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.428|
|[[:human genes:c:cdc6|CDC6]]|0.423|
|[[:human genes:p:psmc6|PSMC6]]|0.422|
|[[:human genes:n:nufip2|NUFIP2]]|0.421|
|[[:human genes:l:lrr1|LRR1]]|0.42|
|[[:human genes:p:ppfia4|PPFIA4]]|0.42|
|[[:human genes:m:myo1h|MYO1H]]|0.415|
|[[:human genes:p:psmd11|PSMD11]]|0.415|
|[[:human genes:n:nup155|NUP155]]|0.415|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.415|
|[[:human genes:r:rps28|RPS28]]|0.414|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.413|
|[[:human genes:p:psma6|PSMA6]]|0.412|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.412|
|[[:human genes:c:cnot1|CNOT1]]|0.411|
|[[:human genes:s:smg1|SMG1]]|0.409|
|[[:human genes:z:zfand5|ZFAND5]]|0.409|
|[[:human genes:c:cdc73|CDC73]]|0.408|
|[[:human genes:k:kpnb1|KPNB1]]|0.406|
|[[:human genes:s:sel1l|SEL1L]]|0.403|
|[[:human genes:s:ssh2|SSH2]]|0.402|
|[[:human genes:n:nupl1|NUPL1]]|0.4|
|[[:human genes:c:cbwd3|CBWD3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 123/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|5/28|
|bone|3/26|
|breast|4/33|
|central nervous system|18/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|6/21|
|liver|3/20|
|lung|13/75|
|lymphocyte|2/16|
|ovary|6/26|
|pancreas|1/24|
|peripheral nervous system|5/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 875
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDC1 Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>