======= NDRG3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDRG3
  * **<color #00a2e8>Official Name</color>**: NDRG family member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57446|57446]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UGV2|Q9UGV2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDRG3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDRG3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605273|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ndr|
|Abhydrolase 1|
|Abhydrolase 6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell growth|
|negative regulation of growth|
|regulation of cell growth|
|spermatogenesis|
|male gamete generation|
|regulation of growth|
|gamete generation|
|molecular function|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|reproductive process|
|reproduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.7|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.79|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.88|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.93|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.93|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.09|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.3|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.43|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.44|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.6|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.35|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|6.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp1a1|ATP1A1]]|0.504|
|[[:human genes:t:tmem161b|TMEM161B]]|0.502|
|[[:human genes:p:pigo|PIGO]]|0.458|
|[[:human genes:a:atp1b3|ATP1B3]]|0.41|
|[[:human genes:p:pigf|PIGF]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 676
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDRG3 Expression in NALM6 Cells: 4.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>