======= NDUFAF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFAF2
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase complex assembly factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91942|91942]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N183|Q8N183]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFAF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFAF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609653|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). {ECO:0000269|PubMed:16200211, ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDUFA12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of insulin secretion involved in cellular response to glucose stimulus|
|negative regulation of insulin secretion|
|negative regulation of peptide hormone secretion|
|NADH dehydrogenase (ubiquinone) activity|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|negative regulation of hormone secretion|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|electron transfer activity|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|reactive oxygen species metabolic process|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|cellular respiration|
|regulation of insulin secretion|
|negative regulation of protein transport|
|electron transport chain|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|negative regulation of secretion|
|energy derivation by oxidation of organic compounds|
|regulation of hormone secretion|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|cellular protein-containing complex assembly|
|regulation of cellular localization|
|oxidation-reduction process|
|regulation of protein localization|
|mitochondrion|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6402
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFAF2 Expression in NALM6 Cells: 4.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>