======= NDUFAF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFAF3
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase complex assembly factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25915|25915]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BU61|Q9BU61]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFAF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFAF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612911|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial complex I assembly protein that interacts with complex I subunits. Mutations in this gene cause mitochondrial complex I deficiency, a fatal neonatal disorder of the oxidative phosphorylation system. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). {ECO:0000269|PubMed:19463981}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF498|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrial inner membrane|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.79|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.71|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.72|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.73|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.76|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.77|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.79|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.88|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.9|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.97|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.99|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.01|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.02|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.07|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.09|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.09|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.16|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.17|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.17|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.22|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.25|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.28|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.34|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.51|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.52|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.78|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.91|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.92|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.07|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb11|NDUFB11]]|0.724|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.687|
|[[:human genes:n:ndufa2|NDUFA2]]|0.686|
|[[:human genes:n:ndufa3|NDUFA3]]|0.675|
|[[:human genes:n:ndufs2|NDUFS2]]|0.668|
|[[:human genes:m:mto1|MTO1]]|0.656|
|[[:human genes:g:grsf1|GRSF1]]|0.655|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.647|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.647|
|[[:human genes:a:acad9|ACAD9]]|0.641|
|[[:human genes:n:ndufa1|NDUFA1]]|0.638|
|[[:human genes:n:nubpl|NUBPL]]|0.63|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.621|
|[[:human genes:n:ndufb5|NDUFB5]]|0.619|
|[[:human genes:n:ndufb9|NDUFB9]]|0.608|
|[[:human genes:n:ndufb6|NDUFB6]]|0.606|
|[[:human genes:n:ndufc2|NDUFC2]]|0.6|
|[[:human genes:e:ecsit|ECSIT]]|0.591|
|[[:human genes:n:ndufs5|NDUFS5]]|0.589|
|[[:human genes:t:tmem261|TMEM261]]|0.582|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.579|
|[[:human genes:n:ndufa8|NDUFA8]]|0.571|
|[[:human genes:n:ndufs8|NDUFS8]]|0.569|
|[[:human genes:n:ndufa11|NDUFA11]]|0.565|
|[[:human genes:n:ndufc1|NDUFC1]]|0.562|
|[[:human genes:f:fastkd2|FASTKD2]]|0.559|
|[[:human genes:p:polg|POLG]]|0.555|
|[[:human genes:n:ndufs7|NDUFS7]]|0.554|
|[[:human genes:q:qrsl1|QRSL1]]|0.55|
|[[:human genes:g:gfm2|GFM2]]|0.549|
|[[:human genes:n:ndufv1|NDUFV1]]|0.546|
|[[:human genes:c:chchd1|CHCHD1]]|0.543|
|[[:human genes:g:gfm1|GFM1]]|0.542|
|[[:human genes:p:pet117|PET117]]|0.542|
|[[:human genes:i:iba57|IBA57]]|0.539|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.539|
|[[:human genes:f:ftsj2|FTSJ2]]|0.537|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.536|
|[[:human genes:t:tars2|TARS2]]|0.535|
|[[:human genes:m:mcat|MCAT]]|0.534|
|[[:human genes:c:coq2|COQ2]]|0.531|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.53|
|[[:human genes:n:ndufb10|NDUFB10]]|0.528|
|[[:human genes:p:polg2|POLG2]]|0.525|
|[[:human genes:n:ndufv2|NDUFV2]]|0.524|
|[[:human genes:c:cars2|CARS2]]|0.523|
|[[:human genes:c:c17orf89|C17orf89]]|0.522|
|[[:human genes:n:ndufa10|NDUFA10]]|0.521|
|[[:human genes:n:ndufb2|NDUFB2]]|0.52|
|[[:human genes:f:foxred1|FOXRED1]]|0.516|
|[[:human genes:r:rpusd4|RPUSD4]]|0.516|
|[[:human genes:c:c12orf65|C12orf65]]|0.515|
|[[:human genes:n:nars2|NARS2]]|0.515|
|[[:human genes:p:polrmt|POLRMT]]|0.513|
|[[:human genes:m:mrpl21|MRPL21]]|0.512|
|[[:human genes:c:coq7|COQ7]]|0.512|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.511|
|[[:human genes:m:mrp63|MRP63]]|0.507|
|[[:human genes:s:selrc1|SELRC1]]|0.507|
|[[:human genes:l:lars2|LARS2]]|0.505|
|[[:human genes:n:ndufa6|NDUFA6]]|0.504|
|[[:human genes:m:mrps25|MRPS25]]|0.501|
|[[:human genes:m:malsu1|MALSU1]]|0.5|
|[[:human genes:n:ndufb7|NDUFB7]]|0.5|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.499|
|[[:human genes:m:mrpl23|MRPL23]]|0.499|
|[[:human genes:p:prim1|PRIM1]]|0.494|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.494|
|[[:human genes:r:rpusd3|RPUSD3]]|0.492|
|[[:human genes:m:mrps21|MRPS21]]|0.489|
|[[:human genes:c:c10orf2|C10orf2]]|0.489|
|[[:human genes:p:pars2|PARS2]]|0.488|
|[[:human genes:n:ndufa5|NDUFA5]]|0.487|
|[[:human genes:w:wars2|WARS2]]|0.486|
|[[:human genes:m:mtg1|MTG1]]|0.485|
|[[:human genes:a:atp5sl|ATP5SL]]|0.484|
|[[:human genes:m:mrps6|MRPS6]]|0.484|
|[[:human genes:m:mterfd1|MTERFD1]]|0.482|
|[[:human genes:n:ndufs1|NDUFS1]]|0.481|
|[[:human genes:m:mrps16|MRPS16]]|0.481|
|[[:human genes:d:dars2|DARS2]]|0.481|
|[[:human genes:y:yars2|YARS2]]|0.481|
|[[:human genes:m:mrpl15|MRPL15]]|0.48|
|[[:human genes:f:fars2|FARS2]]|0.48|
|[[:human genes:m:mrps34|MRPS34]]|0.48|
|[[:human genes:c:coa3|COA3]]|0.48|
|[[:human genes:t:tfb1m|TFB1M]]|0.478|
|[[:human genes:m:mrpl22|MRPL22]]|0.477|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.476|
|[[:human genes:p:pet112|PET112]]|0.476|
|[[:human genes:s:ssbp1|SSBP1]]|0.473|
|[[:human genes:r:rbfa|RBFA]]|0.473|
|[[:human genes:s:sco2|SCO2]]|0.473|
|[[:human genes:m:mrpl44|MRPL44]]|0.471|
|[[:human genes:m:mrps22|MRPS22]]|0.471|
|[[:human genes:m:mettl17|METTL17]]|0.471|
|[[:human genes:t:tefm|TEFM]]|0.47|
|[[:human genes:n:nfu1|NFU1]]|0.468|
|[[:human genes:r:rmnd1|RMND1]]|0.464|
|[[:human genes:p:ptcd3|PTCD3]]|0.464|
|[[:human genes:w:wbscr16|WBSCR16]]|0.464|
|[[:human genes:m:mrps2|MRPS2]]|0.464|
|[[:human genes:p:prepl|PREPL]]|0.463|
|[[:human genes:m:mrps14|MRPS14]]|0.462|
|[[:human genes:m:mrps9|MRPS9]]|0.462|
|[[:human genes:m:mrpl3|MRPL3]]|0.46|
|[[:human genes:v:vars2|VARS2]]|0.459|
|[[:human genes:m:mrpl53|MRPL53]]|0.459|
|[[:human genes:g:glrx5|GLRX5]]|0.459|
|[[:human genes:b:bcs1l|BCS1L]]|0.457|
|[[:human genes:n:ndufb4|NDUFB4]]|0.457|
|[[:human genes:n:ndufa13|NDUFA13]]|0.456|
|[[:human genes:m:mtg2|MTG2]]|0.456|
|[[:human genes:c:coa6|COA6]]|0.454|
|[[:human genes:m:mrps12|MRPS12]]|0.453|
|[[:human genes:m:mrps26|MRPS26]]|0.452|
|[[:human genes:d:dap3|DAP3]]|0.451|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.45|
|[[:human genes:m:mrps5|MRPS5]]|0.45|
|[[:human genes:m:mrpl47|MRPL47]]|0.449|
|[[:human genes:m:mterfd2|MTERFD2]]|0.448|
|[[:human genes:m:mrpl11|MRPL11]]|0.448|
|[[:human genes:m:mrpl28|MRPL28]]|0.447|
|[[:human genes:e:eral1|ERAL1]]|0.447|
|[[:human genes:e:ears2|EARS2]]|0.445|
|[[:human genes:n:ndufs3|NDUFS3]]|0.443|
|[[:human genes:c:coq3|COQ3]]|0.442|
|[[:human genes:m:mrps33|MRPS33]]|0.442|
|[[:human genes:s:sars2|SARS2]]|0.442|
|[[:human genes:p:pnpt1|PNPT1]]|0.44|
|[[:human genes:m:mrps18a|MRPS18A]]|0.439|
|[[:human genes:c:cox16|COX16]]|0.437|
|[[:human genes:m:mrps18b|MRPS18B]]|0.437|
|[[:human genes:t:tomm20|TOMM20]]|0.436|
|[[:human genes:s:sfxn4|SFXN4]]|0.435|
|[[:human genes:m:mrpl45|MRPL45]]|0.434|
|[[:human genes:d:dhx30|DHX30]]|0.434|
|[[:human genes:r:rars2|RARS2]]|0.433|
|[[:human genes:m:mipep|MIPEP]]|0.433|
|[[:human genes:c:cox11|COX11]]|0.433|
|[[:human genes:m:mrps23|MRPS23]]|0.432|
|[[:human genes:t:tufm|TUFM]]|0.431|
|[[:human genes:m:mrps24|MRPS24]]|0.431|
|[[:human genes:m:mrpl55|MRPL55]]|0.431|
|[[:human genes:g:gatc|GATC]]|0.43|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.43|
|[[:human genes:a:aars2|AARS2]]|0.428|
|[[:human genes:n:nsun4|NSUN4]]|0.427|
|[[:human genes:m:mrps10|MRPS10]]|0.426|
|[[:human genes:m:mrpl43|MRPL43]]|0.424|
|[[:human genes:c:cox17|COX17]]|0.424|
|[[:human genes:n:ndufa9|NDUFA9]]|0.424|
|[[:human genes:t:trub2|TRUB2]]|0.421|
|[[:human genes:n:ndufb3|NDUFB3]]|0.421|
|[[:human genes:m:mtif2|MTIF2]]|0.418|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.417|
|[[:human genes:c:cox6c|COX6C]]|0.417|
|[[:human genes:c:c1qbp|C1QBP]]|0.415|
|[[:human genes:a:aifm1|AIFM1]]|0.415|
|[[:human genes:m:mrpl4|MRPL4]]|0.413|
|[[:human genes:m:mrps27|MRPS27]]|0.413|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.413|
|[[:human genes:f:fastkd1|FASTKD1]]|0.412|
|[[:human genes:d:ddx28|DDX28]]|0.412|
|[[:human genes:t:tfam|TFAM]]|0.408|
|[[:human genes:p:pdss1|PDSS1]]|0.408|
|[[:human genes:m:mrpl12|MRPL12]]|0.408|
|[[:human genes:m:mrpl13|MRPL13]]|0.406|
|[[:human genes:m:mtpap|MTPAP]]|0.405|
|[[:human genes:m:mars2|MARS2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 29/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|2/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|2/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1161
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFAF3 Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>