======= NDUFB10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB10
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4716|4716]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O96000|O96000]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603843|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDUFB10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.64|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.83|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.74|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.74|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.77|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.77|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.79|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.81|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.82|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.83|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.86|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.91|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.91|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.97|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.01|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.09|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.12|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.31|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.32|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.52|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:grsf1|GRSF1]]|0.637|
|[[:human genes:n:nubpl|NUBPL]]|0.613|
|[[:human genes:a:acad9|ACAD9]]|0.608|
|[[:human genes:n:ndufa11|NDUFA11]]|0.592|
|[[:human genes:p:pde12|PDE12]]|0.589|
|[[:human genes:m:mto1|MTO1]]|0.571|
|[[:human genes:n:ndufv2|NDUFV2]]|0.563|
|[[:human genes:n:ndufb11|NDUFB11]]|0.559|
|[[:human genes:f:fastkd2|FASTKD2]]|0.556|
|[[:human genes:n:ndufb9|NDUFB9]]|0.552|
|[[:human genes:n:ndufs2|NDUFS2]]|0.543|
|[[:human genes:n:ndufb7|NDUFB7]]|0.537|
|[[:human genes:n:ndufa1|NDUFA1]]|0.537|
|[[:human genes:e:eral1|ERAL1]]|0.536|
|[[:human genes:m:mtif2|MTIF2]]|0.536|
|[[:human genes:n:ndufc1|NDUFC1]]|0.535|
|[[:human genes:c:chchd1|CHCHD1]]|0.533|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.528|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.525|
|[[:human genes:n:ndufa2|NDUFA2]]|0.519|
|[[:human genes:c:cars2|CARS2]]|0.515|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.514|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.51|
|[[:human genes:e:ecsit|ECSIT]]|0.509|
|[[:human genes:p:pet117|PET117]]|0.508|
|[[:human genes:n:ndufs8|NDUFS8]]|0.506|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.5|
|[[:human genes:s:sfxn4|SFXN4]]|0.5|
|[[:human genes:s:ssbp1|SSBP1]]|0.498|
|[[:human genes:n:ndufb6|NDUFB6]]|0.496|
|[[:human genes:n:ndufa10|NDUFA10]]|0.496|
|[[:human genes:n:ndufb2|NDUFB2]]|0.494|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.491|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.49|
|[[:human genes:r:rmnd1|RMND1]]|0.489|
|[[:human genes:n:nsun4|NSUN4]]|0.488|
|[[:human genes:n:ndufa9|NDUFA9]]|0.488|
|[[:human genes:t:tfb1m|TFB1M]]|0.487|
|[[:human genes:n:ndufc2|NDUFC2]]|0.482|
|[[:human genes:n:ndufb4|NDUFB4]]|0.48|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.479|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.478|
|[[:human genes:m:malsu1|MALSU1]]|0.476|
|[[:human genes:n:ndufs5|NDUFS5]]|0.474|
|[[:human genes:f:foxred1|FOXRED1]]|0.473|
|[[:human genes:n:ndufa8|NDUFA8]]|0.469|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.466|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.463|
|[[:human genes:m:mrpl17|MRPL17]]|0.461|
|[[:human genes:n:ndufs3|NDUFS3]]|0.461|
|[[:human genes:m:mrpl28|MRPL28]]|0.46|
|[[:human genes:m:mrpl1|MRPL1]]|0.454|
|[[:human genes:n:ndufs7|NDUFS7]]|0.454|
|[[:human genes:p:prepl|PREPL]]|0.452|
|[[:human genes:c:c1qbp|C1QBP]]|0.448|
|[[:human genes:d:ddx28|DDX28]]|0.448|
|[[:human genes:m:mrps18b|MRPS18B]]|0.448|
|[[:human genes:n:ndufb5|NDUFB5]]|0.447|
|[[:human genes:n:ndufa3|NDUFA3]]|0.447|
|[[:human genes:n:ndufa6|NDUFA6]]|0.444|
|[[:human genes:t:tmem261|TMEM261]]|0.441|
|[[:human genes:m:mcat|MCAT]]|0.44|
|[[:human genes:t:tsfm|TSFM]]|0.439|
|[[:human genes:m:mettl17|METTL17]]|0.435|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.434|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.431|
|[[:human genes:p:pet112|PET112]]|0.429|
|[[:human genes:n:ndufv1|NDUFV1]]|0.429|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.428|
|[[:human genes:m:mrpl45|MRPL45]]|0.426|
|[[:human genes:i:ict1|ICT1]]|0.425|
|[[:human genes:m:mrpl3|MRPL3]]|0.423|
|[[:human genes:g:gfm2|GFM2]]|0.416|
|[[:human genes:p:polg2|POLG2]]|0.415|
|[[:human genes:n:ndufs1|NDUFS1]]|0.411|
|[[:human genes:m:mipep|MIPEP]]|0.411|
|[[:human genes:r:rpusd3|RPUSD3]]|0.411|
|[[:human genes:p:ptcd3|PTCD3]]|0.41|
|[[:human genes:n:ndufb8|NDUFB8]]|0.41|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.407|
|[[:human genes:f:ftsj2|FTSJ2]]|0.406|
|[[:human genes:c:clpx|CLPX]]|0.404|
|[[:human genes:n:nars2|NARS2]]|0.402|
|[[:human genes:a:aars2|AARS2]]|0.401|
|[[:human genes:l:lars2|LARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 75/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|2/28|
|bone|2/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|3/21|
|liver|5/20|
|lung|9/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 607
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB10 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>