======= NDUFB8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB8
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4714|4714]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95169|O95169]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602140|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDUF B8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial matrix|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|endoplasmic reticulum|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.73|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.75|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.84|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.07|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.16|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.38|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.89|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.97|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.56|
|[[:human genes:n:ndufc2|NDUFC2]]|0.493|
|[[:human genes:n:ndufb7|NDUFB7]]|0.482|
|[[:human genes:n:ndufa11|NDUFA11]]|0.48|
|[[:human genes:a:acad9|ACAD9]]|0.476|
|[[:human genes:n:ndufb4|NDUFB4]]|0.474|
|[[:human genes:n:ndufa13|NDUFA13]]|0.466|
|[[:human genes:n:nubpl|NUBPL]]|0.465|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.464|
|[[:human genes:g:grsf1|GRSF1]]|0.459|
|[[:human genes:n:ndufs2|NDUFS2]]|0.458|
|[[:human genes:n:ndufa2|NDUFA2]]|0.453|
|[[:human genes:n:ndufa3|NDUFA3]]|0.452|
|[[:human genes:n:ndufs3|NDUFS3]]|0.45|
|[[:human genes:n:ndufa9|NDUFA9]]|0.443|
|[[:human genes:n:ndufv2|NDUFV2]]|0.439|
|[[:human genes:n:ndufv1|NDUFV1]]|0.438|
|[[:human genes:c:clpp|CLPP]]|0.428|
|[[:human genes:n:ndufa6|NDUFA6]]|0.425|
|[[:human genes:f:fastkd2|FASTKD2]]|0.425|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.424|
|[[:human genes:n:ndufb9|NDUFB9]]|0.422|
|[[:human genes:n:ndufa8|NDUFA8]]|0.422|
|[[:human genes:n:ndufc1|NDUFC1]]|0.416|
|[[:human genes:n:ndufb5|NDUFB5]]|0.413|
|[[:human genes:n:ndufb11|NDUFB11]]|0.411|
|[[:human genes:n:ndufb10|NDUFB10]]|0.41|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.407|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.405|
|[[:human genes:m:mto1|MTO1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 48/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|0/28|
|bone|2/26|
|breast|6/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|2/21|
|liver|2/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 393
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB8 Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>