======= NDUFC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFC2
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit C2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4718|4718]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95298|O95298]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603845|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDUF C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|azurophil granule membrane|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|cellular protein-containing complex assembly|
|leukocyte activation|
|oxidation-reduction process|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.08|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.72|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.82|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.83|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.84|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.86|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.87|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.88|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.95|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.96|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.98|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.98|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.09|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.18|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.23|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.27|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.47|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.69|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.9|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.718|
|[[:human genes:n:ndufa3|NDUFA3]]|0.695|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.668|
|[[:human genes:n:ndufa11|NDUFA11]]|0.665|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.661|
|[[:human genes:n:ndufa2|NDUFA2]]|0.659|
|[[:human genes:n:ndufs2|NDUFS2]]|0.648|
|[[:human genes:n:ndufb9|NDUFB9]]|0.647|
|[[:human genes:n:ndufb11|NDUFB11]]|0.642|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.63|
|[[:human genes:a:acad9|ACAD9]]|0.629|
|[[:human genes:n:nubpl|NUBPL]]|0.622|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.62|
|[[:human genes:n:ndufb5|NDUFB5]]|0.618|
|[[:human genes:n:ndufb7|NDUFB7]]|0.615|
|[[:human genes:l:lars2|LARS2]]|0.605|
|[[:human genes:w:wbscr16|WBSCR16]]|0.602|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.6|
|[[:human genes:m:mrps21|MRPS21]]|0.6|
|[[:human genes:m:mrpl45|MRPL45]]|0.599|
|[[:human genes:n:ndufb4|NDUFB4]]|0.592|
|[[:human genes:n:ndufa13|NDUFA13]]|0.589|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.588|
|[[:human genes:n:ndufc1|NDUFC1]]|0.587|
|[[:human genes:g:grsf1|GRSF1]]|0.584|
|[[:human genes:m:mrpl21|MRPL21]]|0.582|
|[[:human genes:g:gfm1|GFM1]]|0.582|
|[[:human genes:m:mto1|MTO1]]|0.576|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.574|
|[[:human genes:n:ndufv1|NDUFV1]]|0.562|
|[[:human genes:n:ndufs7|NDUFS7]]|0.562|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.562|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.562|
|[[:human genes:g:gfm2|GFM2]]|0.561|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.56|
|[[:human genes:m:mrp63|MRP63]]|0.56|
|[[:human genes:a:atp5sl|ATP5SL]]|0.557|
|[[:human genes:c:c12orf65|C12orf65]]|0.555|
|[[:human genes:n:ndufa5|NDUFA5]]|0.554|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.554|
|[[:human genes:n:nars2|NARS2]]|0.553|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.553|
|[[:human genes:n:ndufs5|NDUFS5]]|0.552|
|[[:human genes:e:ecsit|ECSIT]]|0.552|
|[[:human genes:d:dap3|DAP3]]|0.547|
|[[:human genes:t:tfb1m|TFB1M]]|0.545|
|[[:human genes:t:tmem261|TMEM261]]|0.543|
|[[:human genes:y:yars2|YARS2]]|0.542|
|[[:human genes:c:chchd1|CHCHD1]]|0.542|
|[[:human genes:n:ndufb6|NDUFB6]]|0.541|
|[[:human genes:n:ndufs3|NDUFS3]]|0.539|
|[[:human genes:f:ftsj2|FTSJ2]]|0.538|
|[[:human genes:c:coq7|COQ7]]|0.537|
|[[:human genes:c:cox16|COX16]]|0.537|
|[[:human genes:m:mrpl47|MRPL47]]|0.536|
|[[:human genes:m:mrps6|MRPS6]]|0.536|
|[[:human genes:c:c17orf89|C17orf89]]|0.533|
|[[:human genes:c:c10orf2|C10orf2]]|0.531|
|[[:human genes:p:polg2|POLG2]]|0.53|
|[[:human genes:c:coq2|COQ2]]|0.529|
|[[:human genes:q:qrsl1|QRSL1]]|0.526|
|[[:human genes:m:mtif2|MTIF2]]|0.524|
|[[:human genes:m:mrps16|MRPS16]]|0.522|
|[[:human genes:d:dars2|DARS2]]|0.522|
|[[:human genes:n:ndufa8|NDUFA8]]|0.521|
|[[:human genes:r:rpusd3|RPUSD3]]|0.52|
|[[:human genes:c:cars2|CARS2]]|0.519|
|[[:human genes:m:mrpl23|MRPL23]]|0.516|
|[[:human genes:m:mrpl44|MRPL44]]|0.514|
|[[:human genes:m:mterfd1|MTERFD1]]|0.513|
|[[:human genes:n:ndufa6|NDUFA6]]|0.513|
|[[:human genes:m:mrps26|MRPS26]]|0.512|
|[[:human genes:n:ndufb2|NDUFB2]]|0.511|
|[[:human genes:n:ndufb3|NDUFB3]]|0.511|
|[[:human genes:m:mrps25|MRPS25]]|0.509|
|[[:human genes:n:ndufs1|NDUFS1]]|0.509|
|[[:human genes:m:mrps10|MRPS10]]|0.508|
|[[:human genes:m:mrps34|MRPS34]]|0.506|
|[[:human genes:n:ndufa10|NDUFA10]]|0.506|
|[[:human genes:r:rpusd4|RPUSD4]]|0.506|
|[[:human genes:n:ndufs8|NDUFS8]]|0.504|
|[[:human genes:m:mrps33|MRPS33]]|0.503|
|[[:human genes:f:fastkd2|FASTKD2]]|0.503|
|[[:human genes:p:pnpt1|PNPT1]]|0.502|
|[[:human genes:r:rbfa|RBFA]]|0.502|
|[[:human genes:t:tefm|TEFM]]|0.497|
|[[:human genes:s:selrc1|SELRC1]]|0.497|
|[[:human genes:m:mrpl13|MRPL13]]|0.496|
|[[:human genes:a:atp5c1|ATP5C1]]|0.494|
|[[:human genes:m:mrpl15|MRPL15]]|0.493|
|[[:human genes:n:ndufb8|NDUFB8]]|0.493|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.49|
|[[:human genes:m:mrpl3|MRPL3]]|0.49|
|[[:human genes:s:ssbp1|SSBP1]]|0.489|
|[[:human genes:t:tars2|TARS2]]|0.489|
|[[:human genes:m:mtg1|MTG1]]|0.488|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.488|
|[[:human genes:m:mrps14|MRPS14]]|0.487|
|[[:human genes:r:rars2|RARS2]]|0.486|
|[[:human genes:m:mrpl43|MRPL43]]|0.485|
|[[:human genes:n:ndufv2|NDUFV2]]|0.483|
|[[:human genes:n:ndufb10|NDUFB10]]|0.482|
|[[:human genes:m:mtg2|MTG2]]|0.482|
|[[:human genes:p:pet112|PET112]]|0.481|
|[[:human genes:a:atp5d|ATP5D]]|0.479|
|[[:human genes:a:aifm1|AIFM1]]|0.478|
|[[:human genes:p:pars2|PARS2]]|0.477|
|[[:human genes:h:hars2|HARS2]]|0.476|
|[[:human genes:m:mrps23|MRPS23]]|0.476|
|[[:human genes:c:coq4|COQ4]]|0.475|
|[[:human genes:c:clpp|CLPP]]|0.475|
|[[:human genes:p:pet117|PET117]]|0.473|
|[[:human genes:b:bcs1l|BCS1L]]|0.473|
|[[:human genes:m:mrps5|MRPS5]]|0.472|
|[[:human genes:p:pdss1|PDSS1]]|0.472|
|[[:human genes:m:mrpl53|MRPL53]]|0.471|
|[[:human genes:n:nfu1|NFU1]]|0.47|
|[[:human genes:t:trub2|TRUB2]]|0.47|
|[[:human genes:n:ndufa9|NDUFA9]]|0.469|
|[[:human genes:d:ddx28|DDX28]]|0.468|
|[[:human genes:v:vars2|VARS2]]|0.467|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.466|
|[[:human genes:m:mrpl20|MRPL20]]|0.465|
|[[:human genes:m:mettl17|METTL17]]|0.465|
|[[:human genes:s:sco2|SCO2]]|0.465|
|[[:human genes:t:tufm|TUFM]]|0.463|
|[[:human genes:e:ears2|EARS2]]|0.457|
|[[:human genes:a:aars2|AARS2]]|0.457|
|[[:human genes:m:mrpl12|MRPL12]]|0.456|
|[[:human genes:s:slc25a3|SLC25A3]]|0.455|
|[[:human genes:m:mrps9|MRPS9]]|0.455|
|[[:human genes:f:foxred1|FOXRED1]]|0.454|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.453|
|[[:human genes:p:ptcd3|PTCD3]]|0.453|
|[[:human genes:f:fastkd5|FASTKD5]]|0.452|
|[[:human genes:a:atp5a1|ATP5A1]]|0.451|
|[[:human genes:m:malsu1|MALSU1]]|0.449|
|[[:human genes:m:mrps35|MRPS35]]|0.448|
|[[:human genes:m:mrpl17|MRPL17]]|0.448|
|[[:human genes:m:mrpl41|MRPL41]]|0.447|
|[[:human genes:m:mtpap|MTPAP]]|0.446|
|[[:human genes:m:mrps18a|MRPS18A]]|0.445|
|[[:human genes:w:wars2|WARS2]]|0.445|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.443|
|[[:human genes:g:gatc|GATC]]|0.443|
|[[:human genes:p:polrmt|POLRMT]]|0.442|
|[[:human genes:m:mrpl42|MRPL42]]|0.441|
|[[:human genes:m:mrps22|MRPS22]]|0.441|
|[[:human genes:g:glrx5|GLRX5]]|0.44|
|[[:human genes:c:cox7b|COX7B]]|0.44|
|[[:human genes:s:slc25a26|SLC25A26]]|0.44|
|[[:human genes:d:dhx30|DHX30]]|0.439|
|[[:human genes:c:coa3|COA3]]|0.437|
|[[:human genes:e:eral1|ERAL1]]|0.437|
|[[:human genes:m:mrps7|MRPS7]]|0.437|
|[[:human genes:i:iba57|IBA57]]|0.437|
|[[:human genes:i:isca2|ISCA2]]|0.435|
|[[:human genes:a:atp5b|ATP5B]]|0.434|
|[[:human genes:m:mrpl55|MRPL55]]|0.432|
|[[:human genes:m:mrps12|MRPS12]]|0.432|
|[[:human genes:m:mars2|MARS2]]|0.432|
|[[:human genes:p:polg|POLG]]|0.429|
|[[:human genes:s:slc25a51|SLC25A51]]|0.429|
|[[:human genes:s:slc25a52|SLC25A52]]|0.427|
|[[:human genes:m:mrps18b|MRPS18B]]|0.426|
|[[:human genes:c:cox20|COX20]]|0.426|
|[[:human genes:s:sars2|SARS2]]|0.423|
|[[:human genes:t:tfam|TFAM]]|0.423|
|[[:human genes:a:atp5e|ATP5E]]|0.423|
|[[:human genes:m:mrpl1|MRPL1]]|0.421|
|[[:human genes:f:fars2|FARS2]]|0.419|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.416|
|[[:human genes:m:mrpl46|MRPL46]]|0.416|
|[[:human genes:c:c1qbp|C1QBP]]|0.415|
|[[:human genes:i:ict1|ICT1]]|0.414|
|[[:human genes:m:mipep|MIPEP]]|0.412|
|[[:human genes:c:cox15|COX15]]|0.41|
|[[:human genes:a:atp5h|ATP5H]]|0.409|
|[[:human genes:m:mtif3|MTIF3]]|0.409|
|[[:human genes:c:cox6b1|COX6B1]]|0.408|
|[[:human genes:m:mrps24|MRPS24]]|0.408|
|[[:human genes:m:mterfd2|MTERFD2]]|0.408|
|[[:human genes:c:coa6|COA6]]|0.407|
|[[:human genes:t:tomm20|TOMM20]]|0.406|
|[[:human genes:m:mrps28|MRPS28]]|0.405|
|[[:human genes:m:mrpl33|MRPL33]]|0.404|
|[[:human genes:m:mrps27|MRPS27]]|0.404|
|[[:human genes:t:timm21|TIMM21]]|0.404|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.401|
|[[:human genes:a:alas1|ALAS1]]|0.401|
|[[:human genes:m:mrpl22|MRPL22]]|0.401|
|[[:human genes:m:mrpl35|MRPL35]]|0.4|
|[[:human genes:c:cox19|COX19]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|3/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1284
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFC2 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>