======= NDUFS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFS1
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase core subunit S1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4719|4719]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P28331|P28331]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/157655|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1982|
|Molybdopterin|
|NADH-G 4Fe-4S 3|
|Fer2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma membrane respiratory chain complex I|
|NADH dehydrogenase activity|
|2 iron, 2 sulfur cluster binding|
|4 iron, 4 sulfur cluster binding|
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|apoptotic mitochondrial changes|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|regulation of mitochondrial membrane potential|
|electron transfer activity|
|mitochondrial intermembrane space|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|reactive oxygen species metabolic process|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|regulation of membrane potential|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|apoptotic process|
|oxidation-reduction process|
|programmed cell death|
|cell death|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.7|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.74|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.75|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.79|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.85|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.95|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.11|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.31|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.32|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.575|
|[[:human genes:n:ndufa11|NDUFA11]]|0.573|
|[[:human genes:n:ndufb9|NDUFB9]]|0.538|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.534|
|[[:human genes:n:ndufb11|NDUFB11]]|0.531|
|[[:human genes:n:ndufc1|NDUFC1]]|0.528|
|[[:human genes:n:ndufa3|NDUFA3]]|0.523|
|[[:human genes:n:ndufs2|NDUFS2]]|0.52|
|[[:human genes:g:grsf1|GRSF1]]|0.515|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.514|
|[[:human genes:n:ndufb4|NDUFB4]]|0.514|
|[[:human genes:n:ndufs7|NDUFS7]]|0.513|
|[[:human genes:n:ndufb6|NDUFB6]]|0.51|
|[[:human genes:n:ndufc2|NDUFC2]]|0.509|
|[[:human genes:n:ndufb7|NDUFB7]]|0.501|
|[[:human genes:a:acad9|ACAD9]]|0.501|
|[[:human genes:n:ndufs8|NDUFS8]]|0.498|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.497|
|[[:human genes:n:ndufa2|NDUFA2]]|0.495|
|[[:human genes:n:ndufs5|NDUFS5]]|0.485|
|[[:human genes:n:ndufv1|NDUFV1]]|0.485|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.484|
|[[:human genes:n:ndufs3|NDUFS3]]|0.483|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.481|
|[[:human genes:t:tfb1m|TFB1M]]|0.481|
|[[:human genes:m:mrpl45|MRPL45]]|0.476|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.475|
|[[:human genes:n:nubpl|NUBPL]]|0.471|
|[[:human genes:l:lars2|LARS2]]|0.47|
|[[:human genes:n:ndufa13|NDUFA13]]|0.468|
|[[:human genes:c:cars2|CARS2]]|0.467|
|[[:human genes:m:mrpl21|MRPL21]]|0.464|
|[[:human genes:n:ndufb5|NDUFB5]]|0.461|
|[[:human genes:s:ssbp1|SSBP1]]|0.46|
|[[:human genes:n:ndufa10|NDUFA10]]|0.46|
|[[:human genes:n:nars2|NARS2]]|0.457|
|[[:human genes:m:mto1|MTO1]]|0.456|
|[[:human genes:e:ecsit|ECSIT]]|0.456|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.453|
|[[:human genes:n:ndufa8|NDUFA8]]|0.45|
|[[:human genes:r:rpusd3|RPUSD3]]|0.447|
|[[:human genes:m:mtif2|MTIF2]]|0.443|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.443|
|[[:human genes:m:mrps21|MRPS21]]|0.44|
|[[:human genes:m:mterfd1|MTERFD1]]|0.439|
|[[:human genes:p:pet112|PET112]]|0.439|
|[[:human genes:f:foxred1|FOXRED1]]|0.436|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.435|
|[[:human genes:c:c1qbp|C1QBP]]|0.428|
|[[:human genes:d:dap3|DAP3]]|0.421|
|[[:human genes:c:coq7|COQ7]]|0.421|
|[[:human genes:i:ict1|ICT1]]|0.42|
|[[:human genes:w:wbscr16|WBSCR16]]|0.418|
|[[:human genes:m:mrps23|MRPS23]]|0.417|
|[[:human genes:c:chchd1|CHCHD1]]|0.413|
|[[:human genes:m:mrp63|MRP63]]|0.412|
|[[:human genes:n:ndufb10|NDUFB10]]|0.411|
|[[:human genes:g:gfm2|GFM2]]|0.408|
|[[:human genes:y:yars2|YARS2]]|0.408|
|[[:human genes:p:polg2|POLG2]]|0.403|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.402|
|[[:human genes:t:tefm|TEFM]]|0.402|
|[[:human genes:a:atp5c1|ATP5C1]]|0.402|
|[[:human genes:f:ftsj2|FTSJ2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 48/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|1/26|
|breast|5/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|4/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 899
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFS1 Expression in NALM6 Cells: 7.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>