======= NDUFV1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFV1
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase core subunit V1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4723|4723]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49821|P49821]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFV1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFV1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/161015|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SLBB|
|Complex1 51K|
|NADH 4Fe-4S|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase activity|
|FMN binding|
|NAD binding|
|4 iron, 4 sulfur cluster binding|
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-2.24|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.73|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.75|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.77|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.79|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.86|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.88|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.89|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.91|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.01|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.06|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.07|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.1|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.21|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.22|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.29|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.42|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.6|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufs2|NDUFS2]]|0.643|
|[[:human genes:n:ndufa1|NDUFA1]]|0.641|
|[[:human genes:n:ndufb11|NDUFB11]]|0.605|
|[[:human genes:a:acad9|ACAD9]]|0.604|
|[[:human genes:n:ndufa3|NDUFA3]]|0.599|
|[[:human genes:n:ndufa2|NDUFA2]]|0.586|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.586|
|[[:human genes:n:ndufs5|NDUFS5]]|0.571|
|[[:human genes:n:ndufb9|NDUFB9]]|0.57|
|[[:human genes:n:ndufb7|NDUFB7]]|0.569|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.565|
|[[:human genes:n:ndufc2|NDUFC2]]|0.562|
|[[:human genes:n:ndufa11|NDUFA11]]|0.556|
|[[:human genes:m:mrp63|MRP63]]|0.551|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.546|
|[[:human genes:d:dap3|DAP3]]|0.546|
|[[:human genes:n:nubpl|NUBPL]]|0.542|
|[[:human genes:p:pnpt1|PNPT1]]|0.532|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.53|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.529|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.527|
|[[:human genes:n:ndufs7|NDUFS7]]|0.521|
|[[:human genes:t:trub2|TRUB2]]|0.515|
|[[:human genes:c:cars2|CARS2]]|0.514|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.513|
|[[:human genes:m:mrpl21|MRPL21]]|0.513|
|[[:human genes:f:ftsj2|FTSJ2]]|0.511|
|[[:human genes:n:ndufs8|NDUFS8]]|0.506|
|[[:human genes:m:mrps14|MRPS14]]|0.506|
|[[:human genes:e:ecsit|ECSIT]]|0.504|
|[[:human genes:l:lrpprc|LRPPRC]]|0.503|
|[[:human genes:m:mrps21|MRPS21]]|0.501|
|[[:human genes:n:ndufb4|NDUFB4]]|0.498|
|[[:human genes:m:mrps16|MRPS16]]|0.496|
|[[:human genes:v:vars2|VARS2]]|0.496|
|[[:human genes:p:pet112|PET112]]|0.494|
|[[:human genes:d:dars2|DARS2]]|0.493|
|[[:human genes:m:mto1|MTO1]]|0.492|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.492|
|[[:human genes:t:tefm|TEFM]]|0.491|
|[[:human genes:n:ndufc1|NDUFC1]]|0.491|
|[[:human genes:c:c10orf2|C10orf2]]|0.491|
|[[:human genes:l:lars2|LARS2]]|0.491|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.486|
|[[:human genes:g:grsf1|GRSF1]]|0.485|
|[[:human genes:n:ndufs1|NDUFS1]]|0.485|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.483|
|[[:human genes:m:mrpl47|MRPL47]]|0.482|
|[[:human genes:n:nars2|NARS2]]|0.482|
|[[:human genes:n:nfu1|NFU1]]|0.481|
|[[:human genes:m:mrps25|MRPS25]]|0.48|
|[[:human genes:c:chchd1|CHCHD1]]|0.478|
|[[:human genes:g:gfm1|GFM1]]|0.477|
|[[:human genes:r:rpusd3|RPUSD3]]|0.476|
|[[:human genes:n:ndufa13|NDUFA13]]|0.476|
|[[:human genes:n:ndufa8|NDUFA8]]|0.474|
|[[:human genes:a:aars2|AARS2]]|0.474|
|[[:human genes:m:mrps26|MRPS26]]|0.473|
|[[:human genes:s:selrc1|SELRC1]]|0.471|
|[[:human genes:h:hars2|HARS2]]|0.47|
|[[:human genes:p:pet117|PET117]]|0.467|
|[[:human genes:m:mrps34|MRPS34]]|0.465|
|[[:human genes:n:ndufa5|NDUFA5]]|0.463|
|[[:human genes:q:qrsl1|QRSL1]]|0.462|
|[[:human genes:n:ndufb6|NDUFB6]]|0.462|
|[[:human genes:n:ndufb5|NDUFB5]]|0.461|
|[[:human genes:y:yars2|YARS2]]|0.459|
|[[:human genes:c:c12orf65|C12orf65]]|0.459|
|[[:human genes:c:coq2|COQ2]]|0.459|
|[[:human genes:r:rpusd4|RPUSD4]]|0.458|
|[[:human genes:m:mrpl22|MRPL22]]|0.457|
|[[:human genes:m:mrpl45|MRPL45]]|0.456|
|[[:human genes:f:fars2|FARS2]]|0.455|
|[[:human genes:b:bcs1l|BCS1L]]|0.455|
|[[:human genes:f:fastkd2|FASTKD2]]|0.454|
|[[:human genes:t:tfam|TFAM]]|0.454|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.454|
|[[:human genes:n:ndufb2|NDUFB2]]|0.45|
|[[:human genes:m:mars2|MARS2]]|0.449|
|[[:human genes:t:tufm|TUFM]]|0.448|
|[[:human genes:m:mterfd1|MTERFD1]]|0.447|
|[[:human genes:m:mrps6|MRPS6]]|0.446|
|[[:human genes:m:mrpl23|MRPL23]]|0.446|
|[[:human genes:m:mrpl53|MRPL53]]|0.446|
|[[:human genes:m:mrpl13|MRPL13]]|0.445|
|[[:human genes:a:atp5sl|ATP5SL]]|0.444|
|[[:human genes:t:tars2|TARS2]]|0.443|
|[[:human genes:m:mrps23|MRPS23]]|0.442|
|[[:human genes:c:cox16|COX16]]|0.441|
|[[:human genes:n:ndufs3|NDUFS3]]|0.44|
|[[:human genes:n:ndufb8|NDUFB8]]|0.438|
|[[:human genes:f:fastkd5|FASTKD5]]|0.438|
|[[:human genes:c:coa3|COA3]]|0.437|
|[[:human genes:s:sco2|SCO2]]|0.437|
|[[:human genes:g:gfm2|GFM2]]|0.436|
|[[:human genes:g:glrx5|GLRX5]]|0.436|
|[[:human genes:m:mrps18a|MRPS18A]]|0.433|
|[[:human genes:m:mrpl20|MRPL20]]|0.431|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.43|
|[[:human genes:t:tfb1m|TFB1M]]|0.43|
|[[:human genes:s:slc25a51|SLC25A51]]|0.429|
|[[:human genes:m:mrps24|MRPS24]]|0.429|
|[[:human genes:n:ndufb10|NDUFB10]]|0.429|
|[[:human genes:c:cox6b1|COX6B1]]|0.428|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.426|
|[[:human genes:p:polg2|POLG2]]|0.426|
|[[:human genes:s:sars2|SARS2]]|0.425|
|[[:human genes:c:clpp|CLPP]]|0.424|
|[[:human genes:c:coq7|COQ7]]|0.424|
|[[:human genes:m:mrpl3|MRPL3]]|0.424|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.423|
|[[:human genes:m:mettl17|METTL17]]|0.423|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.423|
|[[:human genes:w:wbscr16|WBSCR16]]|0.422|
|[[:human genes:m:mrps12|MRPS12]]|0.422|
|[[:human genes:a:atp5d|ATP5D]]|0.422|
|[[:human genes:t:tmem242|TMEM242]]|0.42|
|[[:human genes:m:mrpl41|MRPL41]]|0.42|
|[[:human genes:m:mrpl43|MRPL43]]|0.42|
|[[:human genes:n:ndufv2|NDUFV2]]|0.42|
|[[:human genes:p:polrmt|POLRMT]]|0.418|
|[[:human genes:e:ears2|EARS2]]|0.418|
|[[:human genes:m:mrpl52|MRPL52]]|0.418|
|[[:human genes:w:wars2|WARS2]]|0.415|
|[[:human genes:p:ptcd3|PTCD3]]|0.415|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.412|
|[[:human genes:c:c1qbp|C1QBP]]|0.412|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.41|
|[[:human genes:m:mrps9|MRPS9]]|0.41|
|[[:human genes:a:atp5c1|ATP5C1]]|0.407|
|[[:human genes:m:mrpl15|MRPL15]]|0.405|
|[[:human genes:r:rars2|RARS2]]|0.405|
|[[:human genes:s:ssbp1|SSBP1]]|0.404|
|[[:human genes:n:ndufb1|NDUFB1]]|0.404|
|[[:human genes:m:mrps27|MRPS27]]|0.404|
|[[:human genes:e:eral1|ERAL1]]|0.403|
|[[:human genes:a:atp5a1|ATP5A1]]|0.402|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 967
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFV1 Expression in NALM6 Cells: 7.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>