======= NFAM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFAM1
  * **<color #00a2e8>Official Name</color>**: NFAT activating protein with ITAM motif 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=150372|150372]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NET5|Q8NET5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFAM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFAM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross- linking. {ECO:0000269|PubMed:12615919, ECO:0000269|PubMed:15143214}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of B cell receptor signaling pathway|
|positive regulation of antigen receptor-mediated signaling pathway|
|regulation of B cell receptor signaling pathway|
|regulation of B cell differentiation|
|azurophil granule membrane|
|regulation of antigen receptor-mediated signaling pathway|
|B cell differentiation|
|transmembrane signaling receptor activity|
|B cell activation|
|regulation of lymphocyte differentiation|
|regulation of B cell activation|
|lymphocyte differentiation|
|positive regulation of DNA-binding transcription factor activity|
|regulation of leukocyte differentiation|
|leukocyte differentiation|
|lymphocyte activation|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|hemopoiesis|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|immune system development|
|regulation of cytokine production|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|positive regulation of immune response|
|leukocyte activation|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|defense response|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.75|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8615
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFAM1 Expression in NALM6 Cells: 1.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>