======= NFE2L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFE2L1
  * **<color #00a2e8>Official Name</color>**: nuclear factor, erythroid 2 like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4779|4779]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14494|Q14494]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFE2L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFE2L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/163260|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482). {ECO:0000250|UniProtKB:Q61985, ECO:0000269|PubMed:20932482, ECO:0000269|PubMed:24448410}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of nucleus organization|
|regulation of transcription from RNA polymerase II promoter in response to copper ion|
|cysteine transport|
|sulfur amino acid transport|
|fructose 6-phosphate metabolic process|
|cellular response to cold|
|glial cell fate commitment|
|cellular response to cholesterol|
|cellular response to sterol|
|heme biosynthetic process|
|glucose 6-phosphate metabolic process|
|response to cholesterol|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|cellular response to copper ion|
|response to sterol|
|heme metabolic process|
|spinal cord motor neuron differentiation|
|neutral amino acid transport|
|porphyrin-containing compound metabolic process|
|sulfur compound transport|
|response to copper ion|
|ventral spinal cord development|
|cholesterol binding|
|pigment biosynthetic process|
|response to cold|
|promoter-specific chromatin binding|
|cell differentiation in spinal cord|
|glutathione metabolic process|
|tetrapyrrole metabolic process|
|pigment metabolic process|
|transcription regulatory region sequence-specific DNA binding|
|cholesterol homeostasis|
|erythrocyte differentiation|
|sterol homeostasis|
|transcription coregulator activity|
|regulation of response to endoplasmic reticulum stress|
|cellular response to alcohol|
|regulation of fatty acid metabolic process|
|erythrocyte homeostasis|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|spinal cord development|
|myeloid cell homeostasis|
|regulation of glucose metabolic process|
|cholesterol metabolic process|
|amino acid transport|
|secondary alcohol metabolic process|
|lipid homeostasis|
|sterol metabolic process|
|regulation of cellular carbohydrate metabolic process|
|regulation of mitotic nuclear division|
|glial cell differentiation|
|regulation of cellular ketone metabolic process|
|response to temperature stimulus|
|central nervous system neuron differentiation|
|regulation of proteasomal protein catabolic process|
|cellular response to metal ion|
|regulation of nuclear division|
|cellular modified amino acid metabolic process|
|homeostasis of number of cells|
|regulation of carbohydrate metabolic process|
|cofactor biosynthetic process|
|gliogenesis|
|regulation of proteolysis involved in cellular protein catabolic process|
|myeloid cell differentiation|
|cellular response to inorganic substance|
|response to alcohol|
|cellular response to oxidative stress|
|protein domain specific binding|
|cell fate commitment|
|regulation of cellular protein catabolic process|
|response to endoplasmic reticulum stress|
|steroid metabolic process|
|protein-containing complex binding|
|organic acid transport|
|carboxylic acid transport|
|protein polyubiquitination|
|alcohol metabolic process|
|regulation of inflammatory response|
|sulfur compound metabolic process|
|response to metal ion|
|regulation of protein catabolic process|
|response to oxidative stress|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|cofactor metabolic process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|organic hydroxy compound metabolic process|
|organic anion transport|
|transcription by RNA polymerase II|
|inflammatory response|
|cellular response to lipid|
|peptide metabolic process|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|hemopoiesis|
|anion transport|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|protein ubiquitination|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|regulation of defense response|
|protein modification by small protein conjugation|
|cellular amide metabolic process|
|cation transport|
|regulation of cellular catabolic process|
|response to lipid|
|organophosphate metabolic process|
|cellular homeostasis|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|neuron differentiation|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|defense response|
|ion transport|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.48|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.41|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.31|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.2|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.91|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.84|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.71|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.92|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.03|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ngly1|NGLY1]]|0.662|
|[[:human genes:d:ddi2|DDI2]]|0.57|
|[[:human genes:a:atp13a1|ATP13A1]]|0.436|
|[[:human genes:p:psmd11|PSMD11]]|0.425|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1699
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFE2L1 Expression in NALM6 Cells: 6.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>