======= NFS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFS1
  * **<color #00a2e8>Official Name</color>**: NFS1 cysteine desulfurase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9054|9054]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y697|Q9Y697]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603485|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. {ECO:0000269|PubMed:18650437}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Beta elim lyase|
|Aminotran 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine desulfurase activity|
|iron incorporation into metallo-sulfur cluster|
|metal incorporation into metallo-sulfur cluster|
|[2Fe-2S] cluster assembly|
|Mo-molybdopterin cofactor metabolic process|
|Mo-molybdopterin cofactor biosynthetic process|
|prosthetic group metabolic process|
|molybdopterin cofactor metabolic process|
|molybdopterin cofactor biosynthetic process|
|iron-sulfur cluster binding|
|metallo-sulfur cluster assembly|
|iron-sulfur cluster assembly|
|sulfur amino acid metabolic process|
|pyridoxal phosphate binding|
|coenzyme biosynthetic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|cellular amino acid metabolic process|
|sulfur compound metabolic process|
|mitochondrial matrix|
|cofactor metabolic process|
|organophosphate biosynthetic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|heterocycle biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-3.33|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.66|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.51|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-2.31|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.26|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.26|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.18|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.15|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.13|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.11|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.05|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.99|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.98|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.94|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.88|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.73|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.73|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.72|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.72|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.73|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.76|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.77|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.78|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.79|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.94|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|2.14|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sh3bp1|SH3BP1]]|0.409|
|[[:human genes:c:cactin|CACTIN]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 21
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFS1 Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>