======= NGFR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NGFR
  * **<color #00a2e8>Official Name</color>**: nerve growth factor receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4804|4804]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08138|P08138]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NGFR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NGFR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. {ECO:0000250, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNFR c6|
|Death|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|death receptor activity|
|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|neurotrophin binding|
|nerve growth factor binding|
|regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|membrane protein intracellular domain proteolysis|
|neurotrophin TRK receptor signaling pathway|
|negative regulation of sprouting angiogenesis|
|neurotrophin signaling pathway|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|coreceptor activity|
|negative regulation of endothelial cell proliferation|
|membrane protein proteolysis|
|cellular response to amyloid-beta|
|regulation of pri-miRNA transcription by RNA polymerase II|
|neuron apoptotic process|
|response to amyloid-beta|
|neuron death|
|circadian regulation of gene expression|
|regulation of sprouting angiogenesis|
|negative regulation of axonogenesis|
|positive regulation of protein localization to nucleus|
|Rho protein signal transduction|
|amyloid-beta binding|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of axonogenesis|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular glucose homeostasis|
|negative regulation of cysteine-type endopeptidase activity|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|regulation of protein localization to nucleus|
|negative regulation of epithelial cell proliferation|
|regulation of endothelial cell proliferation|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|transmembrane signaling receptor activity|
|circadian rhythm|
|Rab GTPase binding|
|positive regulation of cysteine-type endopeptidase activity|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of endopeptidase activity|
|negative regulation of cell projection organization|
|glucose homeostasis|
|regulation of axonogenesis|
|carbohydrate homeostasis|
|positive regulation of peptidase activity|
|calmodulin binding|
|signaling receptor activity|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of neuron differentiation|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|Ras protein signal transduction|
|negative regulation of peptidase activity|
|endosome|
|rhythmic process|
|positive regulation of neuron projection development|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|ubiquitin protein ligase binding|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|small GTPase mediated signal transduction|
|regulation of vasculature development|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|positive regulation of neurogenesis|
|response to peptide|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|cellular response to organonitrogen compound|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|intracellular protein transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|cell death|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|proteolysis|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10361
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NGFR Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>