======= NIN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NIN
  * **<color #00a2e8>Official Name</color>**: ninein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51199|51199]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N4C6|Q8N4C6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NIN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NIN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608684|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|centrosome-templated microtubule nucleation|
|corpus callosum morphogenesis|
|corticospinal tract morphogenesis|
|microtubule nucleation by microtubule organizing center|
|microtubule minus-end|
|collateral sprouting|
|ciliary transition fiber|
|centriolar subdistal appendage|
|microtubule anchoring at centrosome|
|microtubule anchoring at microtubule organizing center|
|centriole-centriole cohesion|
|corpus callosum development|
|microtubule nucleation|
|pericentriolar material|
|central nervous system projection neuron axonogenesis|
|microtubule anchoring|
|mitotic spindle pole|
|axonal growth cone|
|centrosome localization|
|positive regulation of microtubule polymerization|
|microtubule organizing center localization|
|microtubule polymerization|
|positive regulation of microtubule polymerization or depolymerization|
|central nervous system neuron axonogenesis|
|microtubule polymerization or depolymerization|
|regulation of microtubule polymerization|
|apical part of cell|
|mitotic spindle|
|central nervous system neuron development|
|regulation of microtubule polymerization or depolymerization|
|centrosome cycle|
|positive regulation of axonogenesis|
|protein polymerization|
|developmental cell growth|
|cell growth|
|microtubule organizing center organization|
|kinase binding|
|developmental growth involved in morphogenesis|
|spindle pole|
|positive regulation of protein polymerization|
|centriole|
|positive regulation of cell morphogenesis involved in differentiation|
|central nervous system neuron differentiation|
|regulation of axonogenesis|
|regulation of microtubule cytoskeleton organization|
|positive regulation of supramolecular fiber organization|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|positive regulation of protein complex assembly|
|telencephalon development|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|regulation of supramolecular fiber organization|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|forebrain development|
|developmental growth|
|GTP binding|
|growth|
|axon development|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|centrosome|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cell morphogenesis involved in differentiation|
|organelle localization|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|calcium ion binding|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|nucleolus|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|cell cycle process|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.76|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.78|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.18|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|4.51|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|4.64|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|5.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cradd|CRADD]]|0.656|
|[[:human genes:p:pidd|PIDD]]|0.609|
|[[:human genes:o:odf2|ODF2]]|0.606|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.602|
|[[:human genes:c:c2cd3|C2CD3]]|0.599|
|[[:human genes:c:casp2|CASP2]]|0.598|
|[[:human genes:a:ankrd26|ANKRD26]]|0.583|
|[[:human genes:p:pibf1|PIBF1]]|0.576|
|[[:human genes:o:ofd1|OFD1]]|0.565|
|[[:human genes:c:cep120|CEP120]]|0.56|
|[[:human genes:c:c16orf59|C16orf59]]|0.557|
|[[:human genes:c:cep128|CEP128]]|0.555|
|[[:human genes:c:ccdc41|CCDC41]]|0.548|
|[[:human genes:s:sclt1|SCLT1]]|0.548|
|[[:human genes:f:fopnl|FOPNL]]|0.523|
|[[:human genes:c:cep76|CEP76]]|0.521|
|[[:human genes:c:cep78|CEP78]]|0.508|
|[[:human genes:c:c14orf80|C14orf80]]|0.508|
|[[:human genes:t:tubd1|TUBD1]]|0.462|
|[[:human genes:t:tube1|TUBE1]]|0.411|
|[[:human genes:c:cenpj|CENPJ]]|0.407|
|[[:human genes:w:wbp11|WBP11]]|0.403|
|[[:human genes:h:hyls1|HYLS1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17110
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NIN Expression in NALM6 Cells: 8.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>