======= NKX6-1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NKX6-1
  * **<color #00a2e8>Official Name</color>**: NK6 homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4825|4825]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78426|P78426]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NKX6-1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NKX6-1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602563|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type B pancreatic cell maturation|
|positive regulation of type B pancreatic cell development|
|detection of hexose stimulus|
|detection of carbohydrate stimulus|
|detection of glucose|
|glandular epithelial cell maturation|
|detection of monosaccharide stimulus|
|regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification|
|regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification|
|columnar/cuboidal epithelial cell maturation|
|regulation of type B pancreatic cell development|
|type B pancreatic cell proliferation|
|ventral spinal cord interneuron specification|
|cell fate specification involved in pattern specification|
|spinal cord motor neuron cell fate specification|
|type B pancreatic cell development|
|ventral spinal cord interneuron fate commitment|
|cell fate commitment involved in pattern specification|
|epithelial cell maturation|
|ventral spinal cord interneuron differentiation|
|regulation of transcription involved in cell fate commitment|
|glandular epithelial cell development|
|type B pancreatic cell differentiation|
|enteroendocrine cell differentiation|
|spinal cord dorsal/ventral patterning|
|spinal cord patterning|
|negative regulation of glial cell differentiation|
|neuron fate specification|
|spinal cord motor neuron differentiation|
|endocrine pancreas development|
|glandular epithelial cell differentiation|
|negative regulation of gliogenesis|
|regulation of neuron migration|
|positive regulation of glial cell differentiation|
|ventral spinal cord development|
|columnar/cuboidal epithelial cell development|
|response to nicotine|
|cell differentiation in spinal cord|
|positive regulation of epithelial cell differentiation|
|neuron fate commitment|
|regulation of glial cell differentiation|
|oligodendrocyte differentiation|
|positive regulation of gliogenesis|
|pancreas development|
|smoothened signaling pathway|
|positive regulation of insulin secretion|
|dorsal/ventral pattern formation|
|epithelial cell proliferation|
|cell fate specification|
|columnar/cuboidal epithelial cell differentiation|
|positive regulation of peptide hormone secretion|
|regulation of axon extension|
|spinal cord development|
|regulation of extent of cell growth|
|regulation of gliogenesis|
|neuron migration|
|endocrine system development|
|positive regulation of hormone secretion|
|anatomical structure maturation|
|response to glucose|
|regulation of epithelial cell differentiation|
|response to hexose|
|response to monosaccharide|
|cell maturation|
|glial cell differentiation|
|response to carbohydrate|
|regulation of insulin secretion|
|central nervous system neuron differentiation|
|regulation of cell size|
|regulation of axonogenesis|
|epithelial cell development|
|regulation of peptide hormone secretion|
|gliogenesis|
|developmental maturation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|positive regulation of DNA-binding transcription factor activity|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|cellular response to peptide|
|regulation of developmental growth|
|regionalization|
|negative regulation of cell development|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|response to peptide hormone|
|chromatin binding|
|positive regulation of secretion by cell|
|regulation of cell growth|
|sequence-specific DNA binding|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|pattern specification process|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|response to peptide|
|transcription by RNA polymerase II|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|regulation of anatomical structure size|
|detection of chemical stimulus|
|regulation of hormone levels|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell population proliferation|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of growth|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|detection of stimulus|
|regulation of plasma membrane bounded cell projection organization|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|response to hormone|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.11|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.02|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.72|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2871
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NKX6-1 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>