======= NLRP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLRP2
  * **<color #00a2e8>Official Name</color>**: NLR family pyrin domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55655|55655]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX02|Q9NX02]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLRP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLRP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609364|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NACHT|
|PAAD DAPIN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Pyrin domain binding|
|positive regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 secretion|
|regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-1 secretion|
|positive regulation of interleukin-1 production|
|regulation of interleukin-1 beta production|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of interleukin-1 production|
|nuclear chromosome, telomeric region|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cytokine secretion|
|positive regulation of cysteine-type endopeptidase activity|
|negative regulation of DNA-binding transcription factor activity|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|regulation of cytokine secretion|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|positive regulation of proteolysis|
|positive regulation of secretion by cell|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|intracellular membrane-bounded organelle|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of secretion|
|apoptotic process|
|defense response to other organism|
|Golgi apparatus|
|positive regulation of transport|
|regulation of protein localization|
|programmed cell death|
|cell death|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.02|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.79|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.8|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.84|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3320
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLRP2 Expression in NALM6 Cells: 2.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>