======= NME1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NME1
  * **<color #00a2e8>Official Name</color>**: NME/NM23 nucleoside diphosphate kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4830|4830]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15531|P15531]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NME1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NME1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/156490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:12628186, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:8810265}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NDK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|deoxyribonuclease activity|
|intermediate filament binding|
|UTP biosynthetic process|
|GTP biosynthetic process|
|UTP metabolic process|
|CTP metabolic process|
|CTP biosynthetic process|
|guanosine-containing compound biosynthetic process|
|pyrimidine ribonucleoside triphosphate biosynthetic process|
|pyrimidine ribonucleoside triphosphate metabolic process|
|ribosomal small subunit binding|
|nucleoside diphosphate kinase activity|
|pyrimidine nucleoside triphosphate biosynthetic process|
|pyrimidine ribonucleotide biosynthetic process|
|pyrimidine nucleoside triphosphate metabolic process|
|purine ribonucleoside biosynthetic process|
|ribonucleoside biosynthetic process|
|purine nucleoside biosynthetic process|
|pyrimidine ribonucleotide metabolic process|
|GTP metabolic process|
|gamma-tubulin binding|
|nucleobase-containing small molecule interconversion|
|response to testosterone|
|nucleoside biosynthetic process|
|guanosine-containing compound metabolic process|
|glycosyl compound biosynthetic process|
|lactation|
|purine ribonucleoside triphosphate biosynthetic process|
|pyrimidine nucleotide biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|negative regulation of myeloid leukocyte differentiation|
|response to amine|
|ribonucleoside triphosphate biosynthetic process|
|cellular response to fatty acid|
|positive regulation of DNA binding|
|pyrimidine-containing compound biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside metabolic process|
|pyrimidine nucleotide metabolic process|
|nucleotide phosphorylation|
|nucleoside triphosphate biosynthetic process|
|purine nucleoside metabolic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|body fluid secretion|
|ribonucleoside metabolic process|
|negative regulation of myeloid cell differentiation|
|cellular response to carbohydrate stimulus|
|hippocampus development|
|nucleoside diphosphate metabolic process|
|response to fatty acid|
|cellular glucose homeostasis|
|nucleoside triphosphate metabolic process|
|ruffle membrane|
|response to cAMP|
|negative regulation of leukocyte differentiation|
|nucleobase-containing small molecule biosynthetic process|
|pyrimidine-containing compound metabolic process|
|single-stranded DNA binding|
|nucleoside metabolic process|
|limbic system development|
|regulation of myeloid leukocyte differentiation|
|intermediate filament|
|regulation of DNA binding|
|mammary gland development|
|glycosyl compound metabolic process|
|response to organophosphorus|
|negative regulation of hemopoiesis|
|response to glucose|
|response to hexose|
|response to monosaccharide|
|purine ribonucleotide biosynthetic process|
|response to purine-containing compound|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|mitochondrial outer membrane|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|response to carbohydrate|
|pallium development|
|positive regulation of binding|
|glucose homeostasis|
|carbohydrate homeostasis|
|positive regulation of epithelial cell proliferation|
|response to ketone|
|cellular response to acid chemical|
|magnesium ion binding|
|regulation of myeloid cell differentiation|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|telencephalon development|
|regulation of leukocyte differentiation|
|positive regulation of neuron projection development|
|purine ribonucleotide metabolic process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|regulation of epithelial cell proliferation|
|ribose phosphate metabolic process|
|response to acid chemical|
|enzyme binding|
|purine-containing compound metabolic process|
|positive regulation of neuron differentiation|
|regulation of binding|
|positive regulation of cell projection organization|
|forebrain development|
|GTP binding|
|cellular response to drug|
|gland development|
|negative regulation of immune system process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|centrosome|
|regulation of body fluid levels|
|regulation of neuron projection development|
|cellular response to lipid|
|organophosphate biosynthetic process|
|positive regulation of nervous system development|
|nucleobase-containing small molecule metabolic process|
|positive regulation of cell development|
|endocytosis|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|brain development|
|cellular chemical homeostasis|
|DNA metabolic process|
|head development|
|regulation of neurogenesis|
|response to lipid|
|organophosphate metabolic process|
|cellular homeostasis|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|central nervous system development|
|response to organonitrogen compound|
|response to drug|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.7|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.76|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.78|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18061
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NME1 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>